Core Insights - Ventyx Biosciences, Inc. reported third quarter financial results and highlighted significant progress in its clinical pipeline, particularly with its NLRP3 inhibitors VTX3232 and VTX2735 [1][4] Pipeline Updates and Anticipated Milestones - Ventyx's NLRP3 inhibitor portfolio includes VTX2735, a peripherally restricted NLRP3 inhibitor, and VTX3232, a CNS-penetrant NLRP3 inhibitor [3][10] - The Phase 2 study of VTX3232 in subjects with obesity and cardiovascular risk factors demonstrated a nearly 80% reduction in hsCRP levels within the first week, sustained through week 12, with approximately 70% of patients achieving target hsCRP levels of 2 mg/L or lower [3][4] - VTX3232 also showed significant reductions in IL-6, Lp(a), fibrinogen, and ESR, indicating its potential as a next-generation oral anti-inflammatory therapy for cardiovascular disease [4][5] - Topline data from the Phase 2 study of VTX2735 in recurrent pericarditis is expected in Q4 2025 [4][5] Financial Results - As of September 30, 2025, Ventyx had cash, cash equivalents, and marketable securities totaling $192.6 million, sufficient to fund operations into at least H2 2026 [4][20] - Research and Development (R&D) expenses for Q3 2025 were $17.7 million, a decrease from $30.6 million in Q3 2024 [13][18] - General and Administrative (G&A) expenses were $7.2 million for Q3 2025, compared to $7.9 million in Q3 2024 [13][18] - The net loss for Q3 2025 was $22.8 million, down from $35.2 million in Q3 2024 [13][19]