Achieved $48 million and $184 million in RYTELO® (imetelstat) net product revenue in Q4 2025 and full year 2025, respectively Reported total operating expenses of $255 million for full year 2025, within the previous guidance range Reiterated 2026 RYTELO net product revenue and total operating expenses expected in the ranges of $220 million to $240 million, and $230 million to $240 million, respectively Ended 2025 with cash, cash equivalents, restricted cash and marketable securities of roughly $401 million ...

FOSTER CITY, Calif., Feb. 23, 2026 (GLOBE NEWSWIRE) -- Geron Corporation (Nasdaq: GERN), a commercial-stage biopharmaceutical company aiming to change lives by changing the course of blood cancer, today announced that members of the management team are scheduled to present at the following investor conferences: TD Cowen 46th Annual Healthcare ConferenceFireside Chat on Monday, March 2 at 1:10 p.m. ET in Boston, MABarclays 28th Annual Global Healthcare ConferenceFireside Chat on Tuesday, March 10 at 10:30 a. ...

Core Viewpoint - Geron Corporation is set to release its fourth quarter and full year 2025 financial results on February 25, 2026, and will host a conference call to discuss these results [1][2]. Company Overview - Geron Corporation is a commercial-stage biopharmaceutical company focused on changing the course of blood cancer [3]. - The company's first-in-class telomerase inhibitor, RYTELO (imetelstat), is approved in the United States and the European Union for treating certain adult patients with lower-risk myelodysplastic syndromes (LR-MDS) who have transfusion-dependent anemia [3]. - Geron is conducting a pivotal Phase 3 clinical trial of imetelstat in patients with JAK-inhibitor resistant/refractory myelofibrosis (R/R MF) and is also exploring its use in other hematologic malignancies [3]. - The mechanism of action involves inhibiting telomerase activity, which is elevated in malignant stem and progenitor cells in the bone marrow, potentially reducing proliferation and inducing death of malignant cells [3].

Core Insights - Geron Corporation presented new data at the ASH 2025 Annual Meeting, reinforcing the potential of RYTELO (imetelstat) as a treatment for lower-risk myelodysplastic syndromes (LR-MDS) and myelofibrosis (MF) [1][2][4] Group 1: Clinical Efficacy of Imetelstat - Pooled analyses from the IMerge trial suggest that early treatment-emergent cytopenias may correlate with significant clinical outcomes, including hemoglobin increases and transfusion independence in LR-MDS patients [2][4][6] - The data indicate that patients experiencing ≥75% reductions in neutrophils or ≥50% reductions in platelets during the first two cycles of treatment had greater maximum hemoglobin increases compared to those without such reductions [5][6] - Long-term follow-up from the IMerge trial shows favorable trends in overall survival (OS) and progression-free survival (PFS) for imetelstat-treated patients compared to placebo, with a median follow-up of 45 months [7][8][9] Group 2: Mechanism of Action and Biological Insights - Imetelstat's mechanism involves telomerase inhibition, which is crucial for the uncontrolled cell division seen in LR-MDS, and the treatment has shown potential disease-modifying properties [19][20] - The correlation between early blood count changes and later improvements in hemoglobin provides valuable insights for clinicians regarding the treatment's biological effects [3][6] Group 3: Additional Studies and Future Directions - Ongoing studies, including the IMproveMF trial, are evaluating the safety and efficacy of imetelstat in combination with ruxolitinib for patients with intermediate-2 or high-risk myelofibrosis [13][14] - Preliminary results from the IMpress study indicate that imetelstat has a manageable safety profile in advanced myelodysplastic neoplasms or acute myeloid leukemia patients who are refractory to prior treatments [15][16][17]