Core Insights - Eric Lefkofsky, a notable Chicago entrepreneur, has founded six unicorn companies, including Groupon and Tempus, significantly impacting the tech landscape in Chicago [2][3][8]. Company Overview - Lefkofsky co-founded Groupon in 2008, which once had a valuation of $25 billion but has since declined due to revenue drops, leading to a downsizing in 2024 [5][24]. - Tempus, founded in 2015, is an AI-powered healthcare technology company focused on cancer treatment, currently valued at over $13 billion with a workforce of 4,000 employees [9][16]. Financial Performance - Tempus reported nearly 90% year-over-year revenue growth in Q2 2025, raising its full-year revenue guidance to $1.26 billion and projecting a positive adjusted EBITDA of $5 million for 2025 [16]. - Lefkofsky has invested $100 million into Tempus, which has yet to turn a profit but is expected to do so soon [15][17]. Market Position - Tempus is one of the largest genomic sequencing companies in the U.S., with over 50% of oncologists ordering sequencing tests from the company [15]. - The company is pioneering new technologies in drug research and clinical genomic sequencing, aiming to personalize cancer treatment [13][14]. Future Prospects - Lefkofsky remains focused on Tempus, with plans to continue its growth and integration into mainstream medicine [33]. - The acquisition of Paige, an AI company specializing in digital pathology for $81 million, indicates Tempus's commitment to expanding its technological capabilities [33].