Core Insights - The U.S. stock market has faced significant volatility in early 2025 due to trade policy changes under the new Trump administration, aggressive tariffs, and growing Sino-U.S. trade tensions [1][2] - The federal reserve rate cuts have lowered borrowing costs, positively impacting corporate profitability despite rising manufacturing costs and supply chain issues [2][3] Market Conditions - Trade-related risks and changes in monetary policy have led to frequent stock price fluctuations, but tech stocks have driven positive market momentum [3] - The overall annual inflation rate in 2025 was lower than expected despite a hike in energy prices [3] Growth Drivers for 2026 - Rapid AI infrastructure buildouts are anticipated to be a key growth driver across various industries, requiring substantial investment in computing infrastructure and data centers [4] - Companies with stable earnings and robust cash flow are expected to benefit from the emerging trends in AI investment [4] Company Highlights - **IBM**: Positioned as a major player in the AI landscape, with a free cash flow of $2.37 billion in Q3 2025, and a quarterly dividend of $1.68 per share, yielding 2.2% [7][9][10] - **Analog Devices, Inc. (ADI)**: Benefiting from strong growth in industrial and defense sectors, with an operating cash flow of $4.81 billion in fiscal 2025 and a quarterly dividend of 99 cents per share, yielding 1.43% [12][13][14] - **Johnson & Johnson (JNJ)**: Expected accelerated growth in its Innovative Medicine segment, with $17.22 billion in cash from operating activities and a quarterly dividend of $1.3 per share, yielding 2.5% [15][16] - **The Gap, Inc. (GAP)**: Strong brand performance and market share growth, with net cash from operating activities of $607 million and a quarterly dividend of 16 cents per share, yielding 2.52% [19][20] - **Hewlett Packard Enterprise (HPE)**: Benefiting from traction in the AI networking market, generating $2.5 billion in cash from operating activities and a quarterly dividend of 14 cents per share, yielding 2.33% [21]

Core Viewpoint - Jim Cramer recommends three dividend stocks: Enbridge Inc., Pfizer, and Realty Income, highlighting their strong fundamentals and potential for long-term growth despite market volatility [1][2]. Enbridge Inc. - Enbridge is an oil pipeline company that focuses on the volume of oil transported rather than commodity prices, serving over 7 million U.S. customers [3][4]. - The company has a dividend yield of 5.98%, trading at $47.53, and is expected to add $8 billion in new projects next year, which could enhance cash flow and dividend payouts [5]. - Enbridge has raised its dividends for two consecutive years, paying an annual dividend of $2.84, and is considered to have a low-risk business model with strong fundamentals [5]. Pfizer Inc. - Pfizer is recognized as a dividend giant with a yield of 6.86%, viewed as a "bond equivalent" by Cramer, providing stable returns despite limited share price appreciation [6][7]. - The company has made strategic acquisitions, including Seagen and Metsera, to strengthen its drug pipeline and address patent expirations [7]. - Pfizer generated $14 billion in free cash flow this year, has a payout ratio of 53.13%, and has increased dividends for 15 consecutive years, with a 5-year dividend growth rate of 3.62% [8]. Realty Income - Realty Income is a REIT that leases commercial properties, offering a yield of 5.7% and known as 'The Monthly Dividend Company' [9][10]. - The company has a high occupancy rate of 98.7% and owns 15,500 single-tenant properties, demonstrating resilience even in weaker consumer spending environments [10][11]. - Realty Income has raised its dividend four times this year, pays an annual dividend of $3.24, and has a 4.2% annualized growth rate over the past three decades, making it a reliable high-yield dividend stock [10][11].

Company Performance - Ultragenyx Pharmaceutical Inc. shares fell 42% to $19.84 following the announcement of Phase 3 study results for setrusumab (UX143) in Osteogenesis Imperfecta (OI) [1] - Mereo BioPharma Group plc shares dropped 90% to $0.23 after its Phase 3 studies for setrusumab did not achieve statistical significance against primary endpoints [5] Market Movements - Republic Power Group Ltd surged 163% to $0.69 [5] - Brand Engagement Network Inc jumped 84.3% to $2.21 after entering a Vendor Services Project Agreement [5] - DigitalBridge Group Inc rose 9.9% to $15.30 following the announcement of its acquisition by SoftBank Group for approximately $4.0 billion [5] Precious Metals Sector - Hycroft Mining Holding Corporation was down 14% to $21.61 as precious metal stocks traded lower due to a retreat in commodity prices [6] - Silver prices pulled back after reaching an all-time high, impacting related stocks [6]

All three are buys, but for different reasons.Fears of a recession did not materialize this year. However, it's always worth it for investors to buy shares of companies that can perform well during economic downturns. Solid dividend stocks that routinely increase their payouts are especially attractive in that regard, since they tend to have businesses equipped to withstand challenging times.Let's discuss three stocks to buy to prepare your portfolio for any recession that may lay ahead: Microsoft (MSFT 0.5 ...

High-rolling investors have positioned themselves bullish on Merck & Co (NYSE:MRK), and it's important for retail traders to take note.\This activity came to our attention today through Benzinga's tracking of publicly available options data. The identities of these investors are uncertain, but such a significant move in MRK often signals that someone has privileged information.Today, Benzinga's options scanner spotted 9 options trades for Merck & Co. This is not a typical pattern.The sentiment among these m ...

The Stock Exchange of Hong Kong Limited and the Securities and Futures Commission take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement. Youcare Pharmaceutical Group Co., Ltd. 悅康藥業集團股份有限公司 (the "Company") (A joint stock company incorporated in the People's Republic of China with lim ...

Core Viewpoint - Sanofi is set to acquire Dynavax for approximately $2.2 billion, enhancing its vaccine portfolio amid changing vaccine policies in the US [1][4] Group 1: Acquisition Details - The acquisition price is $15.50 per share in cash, with the deal expected to close in the first quarter of 2026 [1] - Sanofi will gain Dynavax's hepatitis B vaccine HEPLISAV-B, which was approved in the US in 2017 and in Europe in 2021 [2] - Sanofi currently lacks a hepatitis B vaccine in its portfolio, having previously partnered with MSD for a vaccine that is now solely commercialized by MSD [2] Group 2: Product and Market Insights - HEPLISAV-B is administered in a two-dose regimen within one month, contrasting with competitors GSK's Engerix-B and MSD's Recombivax HB, which require three doses over six months [3] - HEPLISAV-B generated sales of $268.4 million in 2024, with Dynavax projecting net product revenue of $305 million to $325 million for 2025 [3] - GlobalData forecasts that HEPLISAV-B will achieve annual sales of $677 million by 2031 [3] Group 3: Industry Context and Regulatory Changes - The acquisition comes amid significant regulatory changes, as the CDC has altered its guidance, no longer recommending hepatitis B vaccination for all US newborns, leading to volatility in the vaccine sector [4] - Analyst Matt Phipps noted that the deal value is slightly below the net present value for HEPLISAV-B, but the acquisition aligns with addressing regulatory concerns and investor expectations for value creation [4] Group 4: Future Prospects - Dynavax's pipeline includes a shingles vaccine candidate, Z-1018, currently in Phase I/II trials, which has shown comparable efficacy to GSK's Shingrix while having fewer adverse reactions [5] - The shingles market is significant, with Shingrix generating £3.4 billion globally for GSK in 2024, indicating the potential market size for Z-1018 [6]

Summary of Key Points from the Conference Call Industry Overview - **Industry**: Biopharma in North America - **Market Analysis**: The latest weekly Total Prescription (TRx) year-over-year (YoY) growth for the week ending December 19, 2025, was +1.1%, compared to +1.0% the previous week and +0.8% over the past 12 weeks [1][2] Prescription Trends - **Weekly TRx Change**: For the week ended December 19, the US total market weekly TRx YoY change was +1.1%, up from +0.9% a year ago. The rolling 4-week TRx YoY was +1.2%, and the rolling 12-week TRx YoY was +0.8% [2] - **Extended Unit (EUTRx) Growth**: EUTRx weekly YoY growth was +1.4%, which is above the TRx YoY growth [2] - **Sequential Growth**: Sequential weekly TRx growth was +2.3%, a significant increase compared to -1.4% the week before [2] Company-Specific Insights Bristol Myers Squibb (BMY) - **Cobenfy Launch**: Cobenfy was approved for schizophrenia on September 26, 2024. The number of prescriptions (scripts) for the week was approximately 2,800, up from 2,710 the previous week. To meet 2025 consensus expectations, Cobenfy TRx needs to track at approximately 2-3 times the volumes from recent schizophrenia launches [3] - **Sales Estimates**: The consensus estimate for Cobenfy has decreased from $196 million to $161 million, implying that around 104,000 TRx are required to meet these estimates [3] Vertex Pharmaceuticals (VRTX) - **Journavx Launch**: Journavx was approved for acute pain on January 30, 2025. The number of scripts for the week was approximately 13,060, up from 12,570 the previous week. Hospital scripts accounted for about 39% of total scripts in Q3 [4] - **Sales Projections**: To achieve 2025 sales of $68 million, approximately 303,000 total scripts are needed, assuming a net price of $225 per script [4] Gilead Sciences (GILD) - **Yeztugo Launch**: Yeztugo was approved on June 18, 2025. The latest week total TRx was approximately 780, down from 800 the previous week. The analysis suggests that achieving FY25 sales of $150 million requires incremental weekly script growth from current levels [5][9] - **Market Coverage**: Yeztugo has secured 75% commercial coverage, including major payers, and most do not require copays, indicating alignment with USPSTF guidelines [9] Additional Insights - **Market Focus**: Investors are increasingly focused on 2026, with strong PrEP market growth of +14% YoY and sustained Descovy share of over 45% [9] - **Pricing Analysis**: The pricing analysis for immunology drugs such as Stelara and Tremfya has been updated, showing how additional indications impact price per script [10] - **Biosimilar Adoption**: Comprehensive analysis of biosimilar adoption across various branded drugs has been included, indicating trends in market share and sales [12] Conclusion - The biopharma industry in North America is showing positive growth trends in total prescriptions, with specific companies like BMY, VRTX, and GILD launching new products and adjusting sales expectations. The focus on 2026 and the strong market coverage for new drugs indicate potential investment opportunities in this sector.

Core Insights - Mind Medicine (MindMed) is advancing its lead candidate MM120, an orally disintegrating tablet for treating generalized anxiety disorder (GAD) and major depressive disorder (MDD) [1] Pipeline Development - Two pivotal phase III studies, Voyage and Panorama, are currently enrolling participants for MM120 ODT in GAD, with the last new drug approval for this condition occurring in 2007 [2] - Phase II study data for MM120 ODT showed efficacy significantly surpassing the current standard of care and a favorable tolerability profile [2] - Top-line data from the Voyage study is expected in the first half of 2026, while Panorama's data is anticipated in the second half of 2026 [3] - The phase III Emerge study for MM120 ODT in MDD has enrolled faster than expected, with top-line data now projected for mid-2026, earlier than previously anticipated [3] - A second phase III study, Ascend, for MDD is planned to start in mid-2026 [3] Financial Performance - MindMed's stock has increased by 101.2% over the past six months, outperforming the industry average increase of 27.6% [4] - The company secured $258.9 million in financing, enhancing its balance sheet and enabling accelerated development of MM120 [5] Additional Pipeline Asset - MindMed's second asset, MM402, is being developed for autism spectrum disorder, with a phase II study expected to begin by the end of 2025 [5] - The year 2026 is projected to be transformational for MindMed with three pivotal data readouts anticipated [5]

Philadelphia, Pennsylvania--(Newsfile Corp. - December 29, 2025) - National plaintiffs' law firm Berger Montague PC announces that a class action lawsuit has been filed against Telix Pharmaceuticals Ltd. (NASDAQ: TLX) ("Telix" or the "Company") on behalf of investors who purchased Telix securities during the period of February 21, 2025 through August 28, 2025 (the "Class Period").Investor Deadline: Investors who purchased Telix securities during the Class Period may, no later than January 9, 2026, seek to ...