Core Viewpoint - A new gene editing tool named evoCAST has been developed by a team from MIT and Harvard's Broad Institute in collaboration with scientists from Columbia University, enabling precise insertion of complete genes into specific locations in the human genome, marking a significant advancement in the treatment of genetic diseases [1] Group 1 - The evoCAST tool allows for the precise embedding of complete genes or multiple genes into the human genome [1] - This development represents a breakthrough in the treatment of hereditary diseases [1] - The research findings have been published in the latest issue of the journal Science [1]

Company Performance - Twist Bioscience (NASDAQ: TWST) reported solid results in the second quarter of FY2025, but the management team appeared downbeat on the earnings call [1] - The company has chosen to spin out its data storage segment, with a fairly modest value attached to the business [1] Investment Insights - Narweena, an asset manager led by Richard Durant, focuses on identifying market dislocations due to poor understanding of long-term business prospects [1] - The firm believes excess risk-adjusted returns can be achieved by identifying businesses with secular growth opportunities in markets with barriers to entry [1] - Narweena's research process emphasizes company and industry fundamentals to uncover unique insights [1] Market Trends - An aging population with low population growth and stagnating productivity growth is expected to create a different opportunity set compared to past trends [1] - Many industries may face stagnation or secular decline, which could improve business performance if competition decreases [1] - Conversely, some businesses may encounter rising costs and diseconomies of scale [1] - The economy is increasingly dominated by asset-light businesses, leading to a declining need for infrastructure investments over time [1] - A large pool of capital is chasing a limited set of investment opportunities, driving up asset prices and compressing risk premia [1]