Sanofi agreed to pay US biotech Dren Bio as much as $1.8 billion as the French company expands a push to develop medicines for immune-system diseases https://t.co/MJnMSKZVXV ...

TORONTO, Dec. 15, 2025 (GLOBE NEWSWIRE) -- PharmAla Biotech Holdings Inc. (“PharmAla” or the “Company”) (CSE: MDMA) (OTC:MDXXF), a biotechnology company focused on the research, development, and manufacturing of novel MDXX class molecules (including its LaNeo™ MDMA), is pleased to announce that its wholly-owned subsidiary, PharmAla Biotech Australia, has contracted with a UK-based CDMO to execute manufacture of its ALA-002 drug substance. “PharmAla Australia worked diligently, executing a global RFP search ...

Core Viewpoint - Vor Bio has entered into a securities purchase agreement to sell 13,876,032 shares of common stock at $10.81 per share, aiming to raise approximately $150 million in gross proceeds before expenses [1][3] Group 1: Financing Details - The private placement involves participation from both new and existing institutional investors, including notable firms such as RA Capital Management and Forbion [2] - Vor Bio did not engage a placement agent for this private placement, which is expected to close around December 18, 2025, pending customary closing conditions [1][3] Group 2: Use of Proceeds - The net proceeds from the private placement will be utilized to advance the clinical development of telitacicept, particularly for ongoing global Phase 3 trials for myasthenia gravis and primary Sjögren's disease, as well as for working capital and general corporate purposes [3] Group 3: Company Overview - Vor Bio is a clinical-stage biotechnology company focused on transforming the treatment of autoimmune diseases through the development of telitacicept, a novel dual-target fusion protein [6]

Core Insights - Dyadic Applied BioSolutions has entered into a commercial agreement with Opes Diagnostics Limited to support the launch of its recombinant proteins for serum-free cell culture media applications in various markets [1][2][4] Company Overview - Dyadic is a global biotechnology company that produces precision-engineered, animal-free proteins and enzymes for life science, food & nutrition, and bioindustrial markets [1][5] - The company utilizes proprietary microbial expression platforms to manufacture recombinant proteins, which are designed to enable customers to develop more efficient and sustainable products [5] Partnership Details - Under the agreement, Opes will leverage its existing relationships to identify potential customers primarily in Europe, Israel, and Asia, facilitating market entry for Dyadic's recombinant protein portfolio [2][3] - The collaboration aims to enhance the penetration of Dyadic's products in industries such as research, diagnostics, cultured meat, and biomanufacturing [3][4] Market Strategy - The partnership is expected to drive the adoption of Dyadic's cell culture media products into expanding markets, transitioning the company from development activities to broader commercial engagement [4]

Core Viewpoint - Jade Biosciences, Inc. has entered into a securities purchase agreement with BB Biotech for a private placement financing expected to yield approximately $45 million in gross proceeds before offering expenses [1][2]. Group 1: Financing Details - Jade is selling 3,214,286 shares of its common stock at a price of $14.00 per share [2]. - The private placement is anticipated to close on or about December 16, 2025, pending customary closing conditions [2]. - The net proceeds from this private placement will be allocated to research and development, general corporate expenses, and working capital needs [2]. Group 2: Securities Information - The securities involved in this transaction are not registered under the Securities Act of 1933 and cannot be reoffered or resold in the U.S. without an effective registration statement or applicable exemption [3]. - A registration rights agreement has been established, obligating the Company to file a registration statement with the SEC for the resale of the shares sold in the private placement [3]. Group 3: Company Overview - Jade Biosciences is a clinical-stage biotechnology company focused on developing therapies for autoimmune diseases [5]. - The lead candidate, JADE101, targets the cytokine APRIL and is currently in a Phase 1 clinical trial for immunoglobulin A nephropathy [5]. - The pipeline includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, and JADE-003, an undisclosed antibody discovery program, both in preclinical development [5].

Core Insights - Zenas BioPharma (ZBIO) stock has experienced significant positive momentum, increasing by 395% year-to-date and outperforming the S&P index [1] Company Overview - Zenas BioPharma has two late-stage assets, specifically obexelimab, which are critical to its growth strategy [1] Analyst Background - The analyst has a Master's degree in Cell Biology and extensive experience in drug discovery, which informs their investment analysis in the biotech sector [1] - The analyst has been active in the investing space for five years, focusing on identifying promising biotechnology companies with innovative approaches [1] Investment Focus - The investment strategy emphasizes evaluating the science behind drug candidates, the competitive landscape, clinical trial design, and potential market opportunities [1] - The goal is to provide insights that help investors understand both opportunities and risks in the biotech sector, which is characterized by breakthrough science and potential for high returns [1]

Core Insights - Ascendis Pharma (ASND) is rumored to be a potential acquisition target in the near term, following strong earnings reported for Q3 2025 [1] Company Performance - The company reported robust Q3 2025 earnings in November, which contributed to the speculation surrounding its acquisition [1] Analyst Background - The analyst has a Master's degree in Cell Biology and extensive experience in drug discovery, which informs their investment analysis in the biotech sector [1] - The focus is on identifying innovative biotechnology companies with unique mechanisms of action and potential to reshape treatment paradigms [1] Investment Approach - The investment strategy emphasizes evaluating the science behind drug candidates, competitive landscape, clinical trial design, and market opportunities while balancing financial fundamentals [1]

Core Viewpoint - Nanobiotix has been admitted to the CAC Mid 60 and SBF 120 indices, enhancing its visibility among institutional investors and strengthening its presence in European equity markets [1][2][3]. Group 1: Company Overview - Nanobiotix is a late-stage clinical biotechnology company focused on physics-based therapeutic approaches for cancer and other major diseases [1][4]. - The company is headquartered in Paris, France, and has been listed on Euronext Paris since 2012 and on Nasdaq since December 2020 [5]. - Nanobiotix holds over 25 umbrella patents related to three nanotechnology platforms, which include applications in oncology, bioavailability, and disorders of the central nervous system [6]. Group 2: Market Impact - Inclusion in the CAC Mid 60 and SBF 120 indices is expected to broaden Nanobiotix's visibility and increase exposure to index-linked investment strategies [2]. - The admission reflects the financial markets' confidence in Nanobiotix's long-term strategy and the potential of its nanotherapeutic solutions [3].

Core Insights - Nanobiotix has been admitted to the CAC Mid 60 and SBF 120 indices following the annual review of the Euronext Paris indices, effective after market close on December 19, 2025, which is expected to enhance its visibility among institutional investors and strengthen its presence in European equity markets [1][2]. Company Overview - Nanobiotix is a late-stage clinical biotechnology company focused on physics-based therapeutic approaches aimed at improving treatment outcomes for cancer and other major diseases [1][4]. - The company is headquartered in Paris, France, and has been listed on Euronext Paris since 2012 and on the Nasdaq Global Select Market since December 2020 [5]. Strategic Significance - The inclusion in the CAC Mid 60 and SBF 120 indices reflects the financial markets' confidence in Nanobiotix's long-term strategy and the potential of its nanotherapeutic solutions [3]. - The company aims to create sustainable value for patients, partners, and shareholders while advancing toward key milestones in physics-based medicine [3]. Intellectual Property - Nanobiotix holds over 25 umbrella patents related to three nanotechnology platforms, which have applications in oncology, bioavailability and biodistribution, and disorders of the central nervous system [6].

Core Insights - Swedish Orphan Biovitrum AB (Sobi) has entered into an acquisition agreement with Arthrosi Therapeutics, Inc. for a total transaction value of up to US$1.5 billion, including an upfront payment of US$950 million and contingent consideration of up to US$550 million, expected to close in the first half of 2026 [1][3]. Company Overview - Arthrosi Therapeutics, Inc. is a late-stage biotechnology company focused on developing pozdeutinurad, a next-generation URAT1 inhibitor aimed at managing gout and tophaceous gout [3][6]. - Sobi is a global biopharma company with approximately 1,900 employees and reported revenue of SEK 26 billion in 2024, dedicated to transforming the lives of individuals with rare diseases [7][8]. Strategic Implications - The acquisition enhances Sobi's gout franchise by adding pozdeutinurad, which is currently in two global Phase 3 clinical studies expected to read out in 2026, potentially becoming a preferred therapy for patients inadequately treated with first-line therapies [3][4]. - The collaboration is anticipated to accelerate growth for Sobi until the mid-2030s and beyond, reflecting a commitment to advancing treatment options for gout patients [4][5]. Financial Impact - Viva Biotech expects the merger to yield an aggregate gain of approximately US$40 million, contingent on regulatory and performance milestones [2].