WALTHAM, Mass., Feb. 04, 2026 (GLOBE NEWSWIRE) -- Zenas BioPharma, Inc. (“Zenas” or the “Company”) (Nasdaq: ZBIO), a clinical-stage global biopharmaceutical company committed to being a leader in the development and commercialization of transformative therapies for patients living with autoimmune diseases, today announced management’s presentation at the Guggenheim Emerging Outlook: Biotech Summit 2026 on Wednesday, February 11, 2026, at 1:30 p.m. ET. A live webcast and archived replay of the Company’s pres ...

NEW YORK, Feb. 03, 2026 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Zenas BioPharma, Inc. (“Zenas” or the “Company”) (NASDAQ: ZBIO). Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext. 7980. The investigation concerns whether Zenas and certain of its officers and/or directors have engaged in securities fraud or other unlawful business practices.  [Click here for information about joining the class action] On January 5, 2 ...

Core Viewpoint - Zenas BioPharma, Inc. is under investigation for potential securities fraud following disappointing results from a clinical trial, which led to significant stock price declines [1][2][3]. Group 1: Company Overview - Zenas BioPharma, Inc. trades on NASDAQ under the ticker ZBIO [1]. - The company recently announced results from the Phase 3 INDIGO trial of obexelimab for Immunoglobulin G4-Related Disease (IgG4-RD) [2]. Group 2: Trial Results and Market Reaction - The trial results were characterized as "positive" by Zenas, but analysts indicated that the drug's efficacy did not meet the necessary threshold for commercial viability [2]. - Following the announcement, Zenas's stock price dropped by $17.89 per share, or 51.86%, closing at $16.61 on January 5, 2026 [2]. - On a subsequent conference call, the CEO expressed disappointment regarding the hazard ratio, which did not meet expectations, resulting in an additional stock price decline of $1.41 per share, or 8.49%, closing at $15.20 on January 6, 2026 [3].

Core Viewpoint - The conference call discusses the top line results of the Phase III INDIGO trial for obexelimab, aimed at treating immunoglobulin G4-related disease (IgG4-RD) [2]. Group 1: Company Overview - Zenas Biopharma is conducting a registrational Phase III trial for obexelimab, which targets IgG4-RD [2]. - The call is being recorded and will be available for replay on the company's website [1]. Group 2: Forward-Looking Statements - The presentation includes forward-looking statements regarding expectations or predictions of future events and performance [3]. - These statements are subject to risks and uncertainties that may lead to actual results differing from those anticipated [3].

Core Viewpoint - Pomerantz LLP is investigating potential securities fraud or unlawful business practices involving Zenas BioPharma, Inc. following a significant drop in stock price after the announcement of Phase 3 trial results for obexelimab [1][3]. Group 1: Company Overview - Zenas BioPharma, Inc. (NASDAQ: ZBIO) is currently under investigation for possible securities fraud [1]. - The company recently announced results from the Phase 3 INDIGO trial of obexelimab for Immunoglobulin G4-Related Disease (IgG4-RD) [3]. Group 2: Financial Impact - Following the announcement of the trial results, Zenas's stock price decreased by $17.89 per share, representing a decline of 51.86%, closing at $16.61 per share on January 5, 2026 [3]. Group 3: Legal Context - Pomerantz LLP is recognized for its expertise in corporate, securities, and antitrust class litigation, having a long history of fighting for victims of securities fraud and corporate misconduct [4].

Core Insights - Zenas BioPharma's phase III INDIGO study for obexelimab in treating IgG4-related disease has met its primary endpoint, showing a significant reduction in flare risk [1][2][7] Study Results - Obexelimab demonstrated a 56% reduction in the risk of IgG4-RD flare compared to placebo over a 52-week period, achieving the primary endpoint of the INDIGO study [2][7] - The treatment also showed significant efficacy across four key secondary endpoints, including reductions in investigator-assessed flares and the number of flares requiring rescue therapy [3][7] Market Reaction - Despite the positive study results, Zenas BioPharma's shares fell by 51.9% on January 5, indicating that the efficacy data may not have met investor expectations [4][7] Future Plans - The company plans to submit a biologics license application to the FDA for obexelimab in Q2 2026 and a marketing authorization application to the European Medicines Agency in the second half of 2026 [5][7] Ongoing Development - Zenas BioPharma is also exploring obexelimab for other autoimmune diseases, with ongoing studies for systemic lupus erythematosus and multiple sclerosis [8][9] - The company is focused on the successful development of obexelimab and other pipeline candidates, as it currently lacks a marketed product [10] Stock Performance - Over the past six months, Zenas BioPharma's shares have increased by 69.7%, outperforming the industry average rise of 21.5% [6]

Market Overview - U.S. stock futures showed mixed results, with Dow futures declining by 0.2% [1] Company-Specific Movements - Jefferson Capital Inc (NASDAQ:JCAP) experienced a significant drop of 4.4%, trading at $22.00, following the announcement of a secondary offering of 10 million shares [1] - MOBIX LABS, INC. (NASDAQ:MOBX) fell sharply by 25.4% to $0.24 due to plans for a common stock offering [2] - Datavault AI Inc (NASDAQ:DVLT) shares decreased by 12.4% to $1.26 after a previous surge of 43% on Monday, linked to a nationwide deployment announcement [2] - BitVentures Ltd – ADR (NASDAQ:BVC) saw a decline of 9.7% to $13.33 after a 5% gain on Monday [2] - Zenas Biopharma Inc (NASDAQ:ZBIO) tumbled by 6.6% to $15.50 following a 52% drop on Monday due to Phase 3 trial results [2] - Theravance Biopharma Inc (NASDAQ:TBPH) dipped 6% to $17.07 after a 3% decline on Friday [2] - Graphic Packaging Holding Co (NYSE:GPK) fell 4.9% to $14.70 ahead of its fourth quarter financial results announcement [2] - ATRenew Inc (NYSE:RERE) declined by 4.1% to $5.65 after a 9% gain on Monday [2] - Rezolve AI PLC (NASDAQ:RZLV) fell 3.7% to $3.07 in pre-market trading [2] - NovaBay Pharmaceuticals Inc (NYSE:NBY) slipped 3.4% to $6.52 after a 15% jump on Monday [2] - Starfighters Space Inc (NYSE:FJET) decreased by 3.3% to $9.08 after a 10% dip on Monday [2]

Core Viewpoint - Zenas BioPharma's shares dropped over 50% following the Phase 3 results for obexelimab in patients with immunoglobulin G4-related disease, as efficacy metrics did not meet market expectations, leading to a significant stock repricing [1][2]. Group 1: Trial Results and Market Reaction - The Phase 3 trial showed a meaningful reduction in flare risk, but the overall efficacy metrics fell short of what the market anticipated, resulting in a sharp decline in stock price [1][2]. - The stock's cyclical positioning indicated elevated risk prior to the trial results, which explains the aggressive selloff [2]. Group 2: Adhishthana Framework Analysis - Zenas BioPharma is currently in Phase 2 of its 18-phase Adhishthana cycle, which is characterized by two segments: the Sankhya period (consolidation and volatility) and the Buddhi period (sustained upside moves) [3]. - The stock's initial rally during the Sankhya period was atypical, as premature rallies in this phase are often unstable and corrected quickly [4][6]. Group 3: Future Outlook and Investment Strategy - Despite the significant decline, caution is advised as Zenas remains in the Sankhya period, with high volatility expected until a transition to the Buddhi phase occurs [7][12]. - Deviations during Phase 2 can impair the quality of any subsequent Buddhi move, suggesting that anticipated rallies may not materialize, supporting a wait-and-watch approach [8][9]. - The recent downgrade from Morgan Stanley aligns with the deteriorating risk profile of the stock, indicating latent structural risks not immediately visible through fundamentals [9][10].

Core Viewpoint - The article highlights the offerings of the Biotech Analysis Central service, which provides in-depth analysis of pharmaceutical companies and investment opportunities in the biotech sector [1][2]. Group 1: Service Offerings - Biotech Analysis Central provides a library of over 600 biotech investing articles, a model portfolio of more than 10 small and mid-cap stocks, and live chat features for investors [2]. - The service is available for $49 per month, with a discounted annual plan at $399, representing a 33.50% savings for subscribers [1]. Group 2: Analyst Background - The author, Terry Chrisomalis, is a private investor with a background in Applied Science, focusing on generating long-term value in the healthcare sector [2]. - The service aims to assist healthcare investors in making informed decisions through comprehensive analysis and news reports [2].

Core Insights - The analysis highlights significant price declines among three companies, emphasizing the volatility in the biotech and technology sectors [1][4][5] Company Summaries Zenas BioPharma Inc. (NASDAQ:ZBIO) - Experienced a -57.30% drop in stock price, falling to $14.73, following the Phase 3 INDIGO trial results for obexelimab despite positive outcomes [1][5] - The market's negative reaction indicates the unpredictable nature of biotech investments [5] Signing Day Sports, Inc. (SGN) - Stock price decreased to $0.51, reflecting a -46.30% change [2] - The company announced an opportunity in AI and HPC infrastructure with BlockchAIn Digital Infrastructure, but competitive pressures and operational challenges may have contributed to the decline [2] Shineco, Inc. (SISI) - Experienced a -37.16% drop, with stock price falling to $0.18 [3] - The company saw a 6.8% decline during mid-day trading, despite a 99% reduction in trading volume, suggesting market competition and regulatory challenges in China's sectors may be impacting its performance [3] Market Trends - The significant price movements among these companies underscore the stock market's volatility, particularly in the biotech and technology sectors [4] - Investors must consider clinical trial outcomes, regulatory decisions, and competitive pressures when making informed decisions in this rapidly changing landscape [4]