Core Insights - A team from Beihang University has developed a flexible implantable bioelectronic device called POCKET, which allows for personalized drug delivery and gene transfection through a novel method of electroporation [1][2] - The device addresses a significant clinical challenge related to hereditary ovarian gene mutations, providing a safer alternative to traditional gene therapy methods that pose risks to sensitive organs [1][2] Group 1: Device Development - The POCKET device is designed to conform to the complex shapes of various organs, utilizing a four-layer functional design that ensures high conformity and large-area adhesion [2] - The research team established a "customized paper-cutting conformal theory," which quantitatively relates geometric parameters of the device to organ curvature and material properties, enabling precise design for specific organs [2] Group 2: Clinical Applications - The POCKET platform has been validated in multiple animal models and ex vivo human tissues, offering new tools for precise treatment of ovarian cancer prevention and organ damage repair [2] - The technology has potential applications beyond ovarian treatment, extending to diseases of the liver, heart, and lungs, thus paving the way for advancements in bioelectronic medicine [2] Group 3: Commercialization - A high-tech company based on this technology has completed multiple rounds of financing, with its first product, the "Ultra-NEP super-permeable device," already applied in skin health [2] - Future plans include expanding the application of this technology in medical-grade devices [2]