New longer-term post hoc analysis results of responders (n=6)1 showed long-lasting, durable pain reduction of nearly 66%, or a mean 5.08 reduction on the VAS pain scale, in patients with severe pancreatic cancer pain 100% of responders (n=7) 1 showed zero opioid use at their 3-month post-procedure follow-up2 Quality of life markers further improved including sleep quality, energy level and ability to lead normal daily and leisure time activities and reduced tension, vomiting and constipation THE WOODLANDS, ...

TORONTO, Aug. 25, 2025 (GLOBE NEWSWIRE) -- Spectral Medical Inc. (“Spectral” or the “Company”) (TSX: EDT), a late-stage theranostic company advancing therapeutic options for sepsis and septic shock, today announced that it has received the US$3 million Tranche B advance from Vantive US Healthcare LLC (“Vantive”) pursuant to the previously disclosed senior secured promissory note entered into in May 2025. The Tranche B advance further strengthens Spectral’s balance sheet and will be used to support ongoing r ...

Market Overview - The market faced challenges as technology and semiconductor stocks experienced significant selling, raising concerns about high valuations and the sustainability of the AI-driven rally [1] - The S&P 500 and Nasdaq Composite indices declined by 0.24% and 0.67%, respectively, indicating a cautious market sentiment [1] - There is a shift in focus towards value stocks due to the current market conditions [1] Value Stocks Evaluation - The Price to Cash Flow (P/CF) ratio is highlighted as an effective metric for evaluating value stocks, with companies like StoneCo Ltd. (STNE), CVS Health Corporation (CVS), Integer Holdings Corporation (ITGR), and USANA Health Sciences, Inc. (USNA) showing low P/CF ratios [2][10] - A low P/CF ratio indicates a favorable market price relative to the cash flow generated per share, making it a reliable indicator of financial health [5][10] Financial Health Indicators - Positive cash flow is essential for a company's liquidity, enabling it to manage debts, reinvest, and return value to shareholders, while negative cash flow indicates declining liquidity [7] - Analysts emphasize that cash flow is a more reliable measure than earnings, which can be influenced by accounting estimates and management practices [6] Value Investing Strategy - A comprehensive approach to value investing should include multiple metrics such as price-to-book ratio, price-to-earnings ratio, and price-to-sales ratio, alongside the P/CF ratio [8] - Stocks should be selected based on parameters like P/CF less than or equal to the industry median, a minimum price of $5, and a Zacks Rank of 1 or 2 for better performance potential [9][11][13] Company Performance Highlights - StoneCo has a Zacks Rank of 1, with a trailing four-quarter earnings surprise of 11.5%, and is projected to see sales and EPS growth of 7.6% and 10.4%, respectively [13][14] - CVS Health holds a Zacks Rank of 2, with a trailing earnings surprise of 22.6%, and is expected to grow sales and EPS by 4.7% and 16.6%, respectively [15] - Integer Holdings, also with a Zacks Rank of 2, anticipates sales and EPS growth of 7.8% and 20.4%, despite a 13.2% decline in share price over the past year [16] - USANA Health Sciences has a Zacks Rank of 2, with a trailing earnings surprise of 21.6%, and is projected to grow sales and EPS by 11.7% and 1.2%, respectively, despite a 21.1% decline in share price [17]

Open Source Advocacy - The industry should support projects only if they are open source [1] - Vitalik Buterin, co-founder of Ethereum, is a major supporter of open source initiatives [1][2] Medical Device Innovation - Openwater is a fully open source medical device company [2] - Openwater aims to develop universal treatments for various diseases, including cancers, mental diseases, neurodegenerative diseases, and infectious diseases, using a single device [2]

The publication, titled "Effects of AtrioVentricular Interval Modulation (AVIM) Therapy in Subjects with Hypertension and Diastolic Dysfunction," reports findings from a retrospective treatment-blinded analysis of MODERATO II patients. The analysis demonstrated that AVIM therapy significantly reduced systolic blood pressure (SBP) and improved echocardiographic markers of DD, a key contributor to HFpEF – a common comorbidity in patients with isolated systolic hypertension (ISH). These results were previously ...

Financial Data and Key Metrics Changes - Revenue for Q2 2025 was approximately $2.9 million, a 100% increase year over year and a slight sequential increase [5][17] - Gross margins improved to 43.6%, more than double the 20.3% reported in Q2 2024, and increased from 42.4% sequentially [5][18] - Adjusted EBITDA loss narrowed to negative $420,000 compared to negative $790,000 for the same period last year [6][20] - Net loss attributable to stockholders was $670,000, down from $890,000 in Q2 2024 [20] Business Line Data and Key Metrics Changes - Contract manufacturing revenue increased to $863,000, a 103% year over year increase from approximately $425,000 in 2024 [6] - Consumer products revenue increased by 95% year over year, driven by growth across the brand portfolio [12] Market Data and Key Metrics Changes - The company is seeing increased demand from domestic companies due to tariffs, although the impact on margins has been mild [35][36] - The partnership with Cintas remains strong, with ongoing sales of the SilverSeal product included in their wound care kits [7][75] Company Strategy and Development Direction - The company aims to continue expanding its contract manufacturing and white label business as a major driver of growth [11] - New product launches are planned, including an expanded beauty line and additional skincare solutions, reflecting the commitment to innovative, high-quality products [12][14] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in achieving positive EBITDA by the end of the year and maintaining guidance for $13 million in revenue [15][81] - The company is preparing for potential economic downturns by focusing on high-margin consumer products and evaluating cost structures [66] Other Important Information - The company received $1 million in non-dilutive funding from STATA to support upcoming product launches and marketing initiatives [15][21] - The company has sufficient cash on hand, including recent capital raises, to support growth initiatives [21] Q&A Session Summary Question: Market opportunities for upcoming launches - Management discussed the potential for new digestive enzyme products, which target larger markets compared to existing products [22][23] Question: Retail strategy and brand consolidation - Management clarified that brands will maintain their unique identities and are currently exploring private label opportunities [25][27] Question: Manufacturing capacity and onboarding new customers - Current manufacturing capacity is underutilized, allowing for onboarding of new customers without immediate expansion [29][30] Question: Impact of tariffs on the business - Management noted a mild negative impact on margins but increased interest from domestic companies [35][36] Question: Status of AbbVie partnership - Management confirmed delays in the AbbVie project but remains optimistic about future developments [40][44] Question: New product details from Silly George - Management highlighted successful new product launches and strong sales performance [48][51] Question: Cash position and recession preparedness - Management is considering strategies for potential economic downturns while maintaining a focus on high-margin products [66] Question: Ranking of partnerships - Management identified key partnerships, including Cintas and AbbVie, as significant opportunities for growth [75]

A consortium led by TPG and the Qatar Investment Authority has offered to buy out Hong Kong-listed Kangji Medical in a deal that values the Chinese medical device maker at about HK$11.2 billion ($1.4 billion) https://t.co/A0lLZxV8Ta ...

Company Overview - AcuityMD 总部位于波士顿，帮助医疗器械制造商寻找合适的医生 [1] - AcuityMD 通过使用 3.25 亿人的匿名数据来制定营销计划 [1] Data Analysis - AcuityMD 使用 3.25 million 人的去标识化数据 [1]

Core Insights - Branded Legacy, Inc. has completed the acquisition of Bio Legacy Evaluative Group, formerly Menlo Health, which positions the company to address global health challenges and enhance shareholder value through innovative technologies and strategic leadership [1][2][8] - The acquisition is expected to drive significant revenue growth, with projections indicating that Bio Legacy could generate up to $183.3 million in revenues by Year 5 [7] Acquisition Details - The acquisition agreement was executed on July 28, 2025, and closed on July 31, 2025, allowing Bio Legacy to operate as a wholly-owned subsidiary of Branded Legacy [5][8] - The deal involved an all-stock transaction valued at $1.5 million in Preferred D stock, aligning the interests of Bio Legacy with existing shareholders [5] Leadership and Vision - Amin Janmohamed has been appointed as CEO, and Dr. Kristian Thorlund as Chairman, bringing expertise to guide the company through its growth trajectory [3][8] - The leadership team is committed to long-term growth and innovation, focusing on delivering measurable results and substantial returns for shareholders [2][8] Product and Market Potential - Bio Legacy's patented intranasal naloxone device aims to address the addiction crisis, with the market expected to grow from $371 million in 2022 to over $1.16 billion by 2032, reflecting a CAGR of approximately 11.9% [4] - The company plans to expand its product offerings into vaccines and cold-chain therapies, tapping into significant untapped markets [4] Roadmap and Milestones - A robust R&D investment of $1 million is planned post-uplisting to OTCQB, with key milestones including manufacturing prototyping in Q3 2025, full patent filings in Q4 2025, and clinical trials in 2026 [6][5] - The naloxone device is set for market launch in Q1 2027, with expectations of substantial revenue contributions to Branded Legacy's portfolio [7]

Core Viewpoint - Orchestra BioMed Holdings, Inc. announced a significant update to the BACKBEAT study protocol, approved by the FDA, which expands patient eligibility criteria for evaluating AVIM therapy in patients with uncontrolled hypertension who require pacemakers [1][5]. Summary by Relevant Sections Patient Eligibility Expansion - The updated protocol increases the eligible patient pool by more than 24-fold compared to the original protocol, supporting the company's target for mid-2026 completion of enrollment [2][5]. - New eligibility criteria include hypertensive patients who have received or are scheduled to receive a Medtronic Azure™ or Astra™ pacemaker, including device replacements [5][6]. Clinical Implications - The expanded criteria align the study population with the characteristics of the FDA Breakthrough Device Designation for AVIM therapy, potentially representing millions of U.S. patients needing better options for managing elevated systolic blood pressure [3][4]. - AVIM therapy is designed specifically for older, higher-risk hypertensive patients who may also require a pacemaker, reflecting its transformative potential [3][8]. Company Overview - Orchestra BioMed focuses on accelerating high-impact biomedical technologies through partnerships with leading medical device companies, with AVIM therapy as its lead product candidate for uncontrolled hypertension [4]. - The company has received four Breakthrough Device Designations from the FDA for its core programs, indicating significant potential to address unmet needs in cardiovascular care [4].