二羟基丙酮
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大化所实现“液态阳光”合成L-乳酸
Zhong Guo Hua Gong Bao· 2025-07-14 01:55
Core Insights - The research team led by Academician Li Can from the Dalian Institute of Chemical Physics has made significant progress in the field of artificial photosynthesis and biomanufacturing, specifically in synthesizing optically pure L-lactic acid using renewable energy sources like solar energy [1][2] - The team has developed a strategy that combines chemical catalysis and biological synthesis, utilizing dihydroxyacetone as an intermediate to convert carbon dioxide and water into L-lactic acid with a high conversion rate [1][2] Group 1 - The team achieved a conversion rate of 99% for dihydroxyacetone to L-lactic acid using Pichia pastoris cells, with a yield of over 100 grams per liter during fed-batch fermentation, showcasing a significant advantage over traditional glucose-based methods [1] - The research highlights the potential of using "liquid sunlight" as a basis for synthesizing various chemicals and high-end chemical products through green biomanufacturing [1][2] Group 2 - The strategy effectively combines the advantages of chemical catalysis for carbon dioxide conversion with the product selectivity of biological synthesis, allowing for the targeted biomanufacturing of high-end bio-based chemicals, including bulk food and feed macromolecular raw materials [2] - Future plans include further technological development and demonstration to scale up the industrial application of synthesizing optically pure L-lactic acid from carbon dioxide and water [2]