Core Viewpoint - The research team has developed a portable microbial fuel cell using 3D printed living hydrogels, which has significant potential for applications in medical devices and sustainable energy supply [1][2]. Group 1: Technology and Innovation - The microbial fuel cell integrates bioelectrical stimulation devices to achieve precise regulation of electrophysiology and blood pressure, showcasing its application potential in disease treatment [1]. - The innovative 3D printed living hydrogel material, based on Shewanella bacteria, allows for the construction of complex structures and enhances mechanical strength and conductivity [2]. - The micro fuel cell, with a diameter of only 20mm, can output a stable voltage of 450mV and complete up to 10 cycles of "self-charging-discharge" [2]. Group 2: Performance and Advantages - The microbial fuel cell demonstrates a high bacterial survival rate of 97% after energy cycles, maintaining over 90% survival even after 100 hours of continuous operation, indicating excellent biocompatibility [2]. - The device avoids the use of scarce metals and toxic electrolytes found in traditional batteries, presenting significant environmental advantages [2]. - Although the energy density is currently at 0.008 watt-hours per liter and power density at 8.31 microwatts per square centimeter, it is sufficient for low-power devices [2]. Group 3: Application and Future Directions - The research targets instantaneous neural stimulation in precision medicine, with successful results in rat experiments showing significant blood pressure reduction [3][4]. - Future plans include developing implantable bio-batteries powered by human blood glucose, aiming for self-sustaining medical devices [4]. - The research reflects a cross-disciplinary innovation between synthetic biology and materials science, with promising applications in medical implants and environmental monitoring sensors [4].