Group 1: Human Monoclonal Antibodies Against Monkeypox Virus - A study published in Cell identified two human monoclonal antibodies (mAb 975 and mAb 981) that provide potential protection against the monkeypox virus in mice and macaques [5][7] - The research revealed high-resolution structures of the antibody-antigen complex, providing insights into the molecular mechanism of how these antibodies recognize the monkeypox virus [7] - This study offers a conceptual validation for the use of these monoclonal antibodies as therapeutic candidates and may inform future vaccine design [7] Group 2: High-Resolution Microbial and Antibiotic Resistance Gene Mapping - A study from Fudan University characterized a high-resolution map of mammalian microbiomes and antibiotic resistance genes (ARGs), identifying over 7,000 previously unreported bacterial species [9][11] - The research found that bacterial strains are widely shared across different hosts and geographic regions, indicating potential cross-host transmission [11] - A total of 521 ARGs were detected, with 157 being highly homologous between human and mammalian microbiomes, highlighting the prevalence of certain ARGs in mammalian microbiomes [11] Group 3: Mechanisms of Nociceptor Resilience to Excitotoxicity - A study from UCSF discovered that reduced expression of mitochondrial electron transport chain components enhances nociceptor resilience to excitotoxicity and oxidative stress [14][17] - The findings suggest that nociceptors actively lower mitochondrial activity to survive harmful stimuli, which has implications for understanding neuropathological consequences in conditions like diabetes and chemotherapy [17][18] Group 4: Localized Mitochondrial Translation - MIT researchers developed a tool called LOCL-TL to monitor localized translation in mammalian cells, revealing two distinct mechanisms of translation on the mitochondrial outer membrane [20][24] - This tool is expected to facilitate research on localized translation's role in various biological processes and its implications in diseases such as cancer and neurological disorders [24] Group 5: Hepatocyte Metabolic Adaptations During Pregnancy and Lactation - A study from Peking University described adaptive changes in mouse hepatocytes during pregnancy and lactation, identifying a "pregnancy clock" that regulates metabolic changes [26][29] - The research highlighted the importance of specific proteins in maintaining liver adaptability during pregnancy and lactation, with potential implications for maternal-fetal health and livestock management [29] Group 6: New Spatial Transcriptomics Technology - Stereo-seq V2 - A new spatial transcriptomics technology, Stereo-seq V2, was introduced, enabling high-resolution, in situ analysis of host-microbe interactions in FFPE samples [32][35] - This technology overcomes limitations of traditional methods, allowing for comprehensive analysis of cellular gene expression and interactions with pathogens [35]

撰文丨王聪 编辑丨王多鱼 排版丨水成文 猴痘 （mpox） ，是一种人畜共患病，由 猴痘病毒 （ MPXV ） 感染所致，其于 1958 年首次在用于研究的猴子中发现，主要在动物中传播。1970 年首次在刚 果 （金） 发现人类猴痘病例，此后猴痘一直在非洲的一些国家流行。而 2022 年爆发的猴痘疫情蔓延至了全球 100 多个国家和地区，世界卫生组织 （WHO） 在 2022 年和 2024 年两度就猴痘疫情发布最高级别预警，宣布其构成"国际关注的突发公共卫生事件" （PHEIC） 。 猴痘病毒包膜粒子上表达的 A35 蛋白 对于猴痘病毒在宿主内的感染和传播至关重要，使其成为有效的抗病毒靶点。 2025 年 8 月 26 日，深圳市第三人民医院 （南方科技大学第二附属医院） /深圳国家感染性疾病临床医学研究中心 张政 教授、 鞠斌 特聘研究员、中国医学科 学院医学实验动物研究所 薛婧 研究员、南方科技大学医学院 鄢仁鸿 副教授、中国疾病预防控制中心病毒病预防控制所 谭文杰 研究员作为共同通讯作者 （ 鞠斌 、 刘聪聪 、 张京京 、 李雅宁 、 杨浩楠 、 周兵 、 黄保英 为共同第一作者 ） 在国际顶尖学术 ...