Core Viewpoint - Recent advancements in the research of methanol dehydrogenase (MDH) by the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, provide a new pathway to address the challenge of simultaneously enhancing conversion rate and efficiency in methanol bioconversion technology [1] Group 1: Research Progress - The development of methanol bioconversion technology has been limited by the lack of methanol oxidoreductases that possess both high energy efficiency and high catalytic rates [1] - Researchers focused on the PQQ-dependent methanol dehydrogenase, which naturally exhibits excellent energy efficiency and catalytic rates for methanol oxidation [1] - By rationally reconstructing and optimizing a biosynthetic gene cluster composed of 14 genes, the enzyme was successfully heterologously synthesized and correctly assembled in Escherichia coli, overcoming the technical bottleneck of relying on natural host isolation and purification [1] Group 2: Implications for Industry - This achievement provides a high-performance biocatalyst for methanol bioconversion technology, which is expected to enhance the efficiency and stability of methanol bioconversion [1] - The advancements are likely to promote the scaling up of this technology for industrial applications [1]