Core Viewpoint - The article highlights a new breakthrough in addressing chronic constipation through gut microbiota regulation, as outlined in the "Clinical Application of Gut Microecology in Chronic Constipation Expert Consensus (2024 Edition)" released by authoritative institutions [1]. Group 1: Gut Microbiota and Chronic Constipation - The consensus indicates that dysbiosis in gut microbiota and chronic constipation are interrelated, creating a vicious cycle [1]. - Patients with constipation show a significant reduction in beneficial bacteria (e.g., Bifidobacterium, Lactobacillus) and an increase in harmful bacteria (e.g., certain Enterobacteriaceae) [1]. - The imbalance in gut microbiota affects the production of short-chain fatty acids that promote intestinal motility and disrupts neurotransmitter (e.g., serotonin) and bile acid metabolism, leading to decreased gut motility [1]. Group 2: Broader Implications of Constipation - The consensus emphasizes the "cross-border impact" of constipation, linking it to various comorbidities through the "gut-brain axis" [1]. - The Wenden District People's Hospital has initiated the application of microbiota transplantation in digestive diseases, liver diseases, and tumor-related diseases, with plans to expand into psychological and endocrine disorders [1].