Core Viewpoint - Prostate cancer is a significant health concern for older men, often referred to as a "silent killer" due to its asymptomatic early stages, making early detection crucial for effective treatment [1][6]. Early Stage: Silent "Lurker" - Early prostate cancer typically shows no obvious symptoms, necessitating professional screening methods for detection [3]. - The serum prostate-specific antigen (PSA) test is a key early detection tool, with healthy males under 40 having PSA levels ≤4 ng/ml, while 97% of healthy males over 40 fall within 0 ng/ml to 4 ng/ml [4]. - Digital rectal examination (DRE) remains a common screening method, although its sensitivity for early detection may be limited compared to PSA testing [5]. Advanced Stage: Emerging "Troublemaker" - As prostate cancer progresses, symptoms such as urinary obstruction become apparent, leading to increased frequency, urgency, and difficulty in urination [8]. - Hematuria, or blood in urine, serves as a critical signal for advanced prostate cancer, often presenting as painless visible blood in urine [9][10]. Late Stage: Rampant "Storm" - In late-stage prostate cancer, bone pain becomes prevalent due to metastasis, often affecting areas like the lower back, hips, and pelvis [12]. - Pathological fractures may occur as cancer cells weaken bone structure, leading to fractures from minimal trauma [13]. - Lymph node enlargement is another indicator of late-stage cancer, particularly in the groin and pelvic regions, signaling advanced disease [15]. - Systemic symptoms such as anemia, weakness, weight loss, low-grade fever, and lower limb edema may manifest as the disease progresses [16]. Prevention and Detection - Regular health check-ups, particularly PSA testing and DRE, are essential for early detection of prostate cancer [18]. - Advances in medical treatments can effectively manage the disease and improve quality of life for diagnosed patients [19].