Core Viewpoint - High-end scientific instruments are crucial for research and technological innovation, but domestic instruments in China are still in the early stages of development and face significant challenges in replacing imported counterparts [1] Group 1: Current State of Domestic Instruments - Domestic scientific instruments, particularly in the high-end market, are largely dominated by foreign companies, with many universities relying on imported equipment due to the current limitations of domestic products [2] - The Shanghai Jiao Tong University (SJTU) analysis testing center has installed a 400 MHz domestic liquid nuclear magnetic resonance (NMR) spectrometer, which performs comparably to imported models in terms of sensitivity and resolution, with an annual usage exceeding 1800 hours [2][3] Group 2: Advantages of University Testing - SJTU provides a unique testing environment for domestic instruments, allowing for real-time feedback on performance issues, which aids in the iterative improvement of these products [3] - The high frequency of use and diverse sample types at SJTU accelerate the development and upgrade of domestic instruments [3] Group 3: Challenges in Adoption - There are significant gaps in stability and precision between domestic and advanced imported instruments, leading to hesitance in procurement by universities [4] - The process of trialing domestic instruments often requires substantial human and time resources, which can be a barrier for startups lacking the financial capacity to engage in extensive testing [4] Group 4: Proposed Solutions - SJTU plans to establish an instrument validation demonstration center and a waste instrument dismantling workshop to support the development of domestic instruments [5] - The validation center will serve as a practical testing ground for domestic instruments, facilitating continuous improvement based on real experimental conditions [5][6] - The dismantling workshop aims to repurpose high-precision instruments that are no longer in use, promoting resource efficiency and fostering interdisciplinary collaboration for talent development [6]