AAV manufacturing approach

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Lexeo Therapeutics to Present New CMC Data at the 28th American Society of Gene & Cell Therapy (ASGCT) Annual Meeting
Globenewswireยท 2025-05-01 13:16
Core Insights - Lexeo Therapeutics, Inc. is presenting new data on its AAV manufacturing approach at the upcoming ASGCT meeting, highlighting advancements in production efficiency and quality [1][2] - The company has optimized a manufacturing platform that enhances scalability, reduces costs, and maintains the purity and potency of AAV products, which is crucial for its clinical-stage gene therapy programs [2] Company Overview - Lexeo Therapeutics is a clinical stage genetic medicine company based in New York City, focused on innovative treatments for cardiovascular diseases [3] - The company is developing therapeutic candidates targeting genetic causes of conditions such as Friedreich ataxia cardiomyopathy and plakophilin-2 arrhythmogenic cardiomyopathy, addressing significant unmet medical needs [3] Presentation Details - Lexeo will present two key abstracts at the ASGCT meeting: - "Improving VP1 Ratios Impact on CQAs in rh10 AAV Manufactured through Sf9 Platform" on May 13, 2025 [2] - "Development of a Novel High-Yielding Scalable Sf9-Baculovirus Platform to Produce Quality AAV at 200L Scale" on May 15, 2025 [2]