NEW YORK, Jan. 27, 2026 (GLOBE NEWSWIRE) -- Lexeo Therapeutics, Inc. (Nasdaq: LXEO), a clinical stage genetic medicine company dedicated to pioneering novel treatments for cardiovascular diseases, today announced a series of key senior leadership appointments that underscore the company’s continued and growing expertise in cardiovascular medicine and late-stage clinical development. The company also provided an update on the strategic partnership announced in June 2025 with Perceptive Xontogeny Venture Fund ...

PresentationWelcome, everyone, to the 44th Annual JPMorgan Healthcare Conference. My name is Tessa Romero, and I'm one of the senior biotech analysts here at JPMorgan. We're pleased to welcome our next presenting company, Lexeo Therapeutics, to kick off our Wednesday. And presenting on behalf of the company, we have CEO, Nolan Townsend. Nolan, over to you.Thank you, Tess. It's great to be here, and thanks, everyone, for coming. We're going to start with a short video to give a flavor of the type of diseases ...

Lexeo Therapeutics (NasdaqGM:LXEO) FY Conference January 14, 2026 10:30 AM ET Company ParticipantsEric Adler - Chief Medical Officer and Head of ResearchNone - Video NarratorR. Nolan Townsend - CEOConference Call ParticipantsTessa Romero - Senior Biotech AnalystTessa RomeroWelcome, everyone, to the 44th Annual J.P. Morgan Healthcare Conference. My name is Tessa Romero, and I'm one of the Senior Biotech Analysts here at J.P. Morgan. We're pleased to welcome our next presenting company, Lexeo Therapeutics, to ...

PresentationI would now like to turn the conference call over to Louis Tamayo, Chief Financial Officer of Lexeo Therapeutics. Louis, please go ahead.Good morning, and welcome to Lexeo Therapeutics webcast presentation on LX2020 for the treatment of PKP2-associated arrhythmogenic cardiomyopathy. As a reminder, this call is being recorded today, January 12.Louis TamayoCFO & Principal Accounting Officer Earlier today, we released interim data from the Lexeo HEROIC-PKP2 Phase I/II clinical trial of LX2020 for t ...

Lexeo Therapeutics (NasdaqGM:LXEO) Update / briefing January 12, 2026 08:00 AM ET Company ParticipantsEric Adler - Head of ResearchNolan Townsend - CEOLouis Tamayo - CFOConference Call ParticipantsBrian Skorney - AnalystMichael Okunewitch - AnalystMoritz Reiterer - AnalystNone - AnalystKristen Kluska - AnalystChris Raymond - AnalystRohan Mathur - AnalystGeulah Livshits - AnalystOperatorGood morning and welcome to Lexeo Therapeutics' webcast presentation on LX2020 for the treatment of PKP2-associated arrhyth ...

Core Insights - Lexeo Therapeutics announced preliminary data from the HEROIC-PKP2 Phase I/II clinical trial of LX2020, indicating that the treatment was generally well tolerated and led to significant improvements in PKP2 protein expression and arrhythmia burden in participants [2][3]. Group 1: Clinical Trial Results - The HEROIC-PKP2 trial involved ten participants, with three in the low-dose cohort and seven in the high-dose cohorts [4]. - LX2020 resulted in a mean increase in PKP2 protein expression of 93% in the low-dose cohort and 162% in the high-dose cohorts [8]. - Non-sustained ventricular tachycardia (NSVT) showed a 22% mean improvement in high-dose cohorts, while premature ventricular contractions (PVCs) had a 14% mean improvement [7][13]. - Four out of five participants in high-dose cohorts reported improvement on the Patient Global Impression of Change (PGIC) scale [13]. Group 2: Safety Profile - LX2020 was generally well tolerated, with no clinically significant complement activation reported [8]. - Elevations in liver function tests were observed in five participants at the high dose but resolved without complications [8]. - One serious adverse event of sustained ventricular tachycardia was noted, assessed as possibly treatment-related, but the participant was successfully treated [8]. Group 3: Next Steps and Future Outlook - The company plans to host a webcast to discuss these findings and future developments [9]. - Enrollment for the HEROIC-PKP2 trial was completed in Q4 2025, with 12-month data expected for all high-dose participants in Q4 2026 [13]. - Regulatory engagement is anticipated in 2026 as the company advances the development of LX2020 [13].

Collaboration will combine Lexeo expertise in cardiac genetic medicine with Johnson & Johnson’s expertise in cardiovascular therapeutics and circulatory technologies, including Impella™ heart pumps Agreement will enable accelerated development of a preclinical cardiac target using novel, localized routes of viral gene therapy administration NEW YORK, Jan. 08, 2026 (GLOBE NEWSWIRE) -- Lexeo Therapeutics, Inc. (Nasdaq: LXEO), a clinical stage genetic medicine company dedicated to pioneering novel treatments ...

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Core Insights - The FDA is open to an accelerated approval pathway for Lexeo's LX2006, with pivotal data expected in 2027 and a registrational study planned for the first half of 2026 [1][2]. Company Overview - Lexeo Therapeutics is a clinical-stage biotech focused on gene therapies for inherited cardiovascular diseases and APOE4-associated Alzheimer's, aiming to address the genetic roots of these conditions [4]. Product Pipeline - The leading program, LX2006, is an AAV-based gene therapy targeting Friedreich's ataxia cardiomyopathy, showing promising interim results in Phase I/II studies, including reductions in left ventricular mass index (LVMI) [2][10]. - Another candidate, LX2020, is also in Phase I/II, targeting PKP2-ACM with FDA Orphan Drug and Fast Track designations, with updates expected in January [8]. Market Position and Analyst Sentiment - Analysts from Raymond James highlight Lexeo's advancing clinical data and regulatory momentum, projecting a positive outlook as 2026 approaches [9]. - The stock is rated as a Strong Buy by all 9 analysts, with a current price of $10.56 and an average price target of $20.25, indicating a potential ~92% gain in the next 12 months [11]. Financial Projections - Revenue projections for LX2006 are estimated at $14.1 million in FY27, increasing to $805.3 million by FY32, reflecting strong anticipated growth [10].