Core Insights - Adlai Nortye Ltd. is set to present its novel CEACAM5-targeting antibody-drug conjugate (ADC), AN4035, at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston from October 22-26, 2025 [1][4]. Group 1: AN4035 Development - AN4035 is designed to address the limitations of current pan-RAS(ON) inhibitors by targeting tumors directly, thereby reducing systemic toxicities and widening the therapeutic window [2][3]. - The ADC approach of AN4035 aims to improve efficacy while minimizing on-target, off-tumor toxicities, particularly for RAS-addicted tumors such as colorectal cancer [3][6]. Group 2: Presentation Details - The oral presentation will take place on October 25, 2025, from 11:45 AM to 12:15 PM ET, focusing on novel therapeutic agents [4]. - A poster presentation will also be held on the same day, showcasing the discovery of AN4035 [4]. Group 3: Efficacy and Safety - AN4035 has shown strong intracellular payload retention and significant cytotoxicity in CEACAM5-positive/RAS-addicted cancer cell lines, achieving a 73% objective response rate in a patient-derived xenograft trial with 26 participants [5]. - Preliminary toxicology results in cynomolgus monkeys indicate a favorable safety profile for AN4035 [5]. Group 4: Company Overview - Adlai Nortye is a clinical-stage biotechnology company focused on innovative cancer therapies, with R&D centers in the U.S. and China [7]. - The company is advancing a portfolio that includes next-generation PD-1/L1 modulation and RAS-targeted therapies, highlighting its commitment to developing transformative oncology treatments [7].

Core Insights - Adlai Nortye Ltd. is a clinical-stage biotechnology company focused on developing innovative cancer therapies and will present at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston from October 22-26, 2025 [1][2] Company Overview - Adlai Nortye operates globally with R&D centers in the U.S. and China, advancing a portfolio of innovative drug candidates in two key therapeutic areas: next-generation PD-1/L1 modulation and RAS-targeted therapies [3] - Key drug candidates include AN8025, a multifunctional fusion protein for T cell and antigen-presenting cell modulation; AN4005, a first-in-class oral small-molecule PD-L1 inhibitor; AN9025, an oral pan-RAS(ON) inhibitor; and AN4035, a novel CEACAM5-targeting antibody-drug conjugate [3]