Core Insights - Esperion Therapeutics is a commercial stage biopharmaceutical company focused on developing new medicines for unmet patient needs, particularly in cardiovascular disease [2] - The company has developed the only FDA-approved oral, once-daily, non-statin medications for patients with elevated LDL-C levels [2] - Esperion is advancing its next-generation program targeting ATP citrate lyase inhibitors (ACLYi), leveraging new insights for rational drug design [2] Company Developments - Esperion will present at the Jefferies Global Healthcare Conference in London on November 18, 2025, at 8:00 a.m. GMT [1] - The company continues to evolve through commercial execution, international partnerships, and advancements in its pre-clinical pipeline [3] Contact Information - Investor relations contact: Alina Venezia, email: investorrelations@esperion.com, phone: (734) 887-3903 [4] - Media contact: Tiffany Aldrich, email: corporateteam@esperion.com, phone: (616) 443-8438 [4]

Core Insights - Esperion is hosting a virtual key opinion leader (KOL) event to discuss the challenges of statin intolerance and its impact on patient outcomes, emphasizing the company's commitment to addressing this unmet need [1][2] Company Overview - Esperion Therapeutics is a commercial stage biopharmaceutical company focused on developing new medicines for patients at risk of cardiovascular disease, specifically targeting elevated low-density lipoprotein cholesterol (LDL-C) [3] - The company has developed the only FDA-approved oral, once-daily, non-statin medications for this patient population, supported by the CLEAR Cardiovascular Outcomes Trial involving nearly 14,000 patients [3] - Esperion is advancing its next-generation program focused on ATP citrate lyase inhibitors (ACLYi), leveraging new insights for rational drug design [3] Industry Context - Cardiovascular disease is the leading cause of morbidity and mortality globally, with nearly 20% of patients discontinuing statin therapy within the first year, often without transitioning to alternative treatments [2] - The urgent need for innovative solutions in cardiovascular care is highlighted, as patients who discontinue statin therapy remain vulnerable to serious cardiovascular events [2]

Core Insights - Esperion announced acceptance of an oral and a poster presentation at the AHA Scientific Sessions 2025, highlighting ongoing research in cardiovascular health [1][2] Group 1: Presentations - The oral presentation will focus on bempedoic acid monotherapy, LDL cholesterol, and cardiovascular events, based on a secondary analysis of the CLEAR Outcomes trial [2] - A poster presentation will discuss the effects of bempedoic acid on venous thromboembolism, derived from a post-hoc analysis of the CLEAR Outcomes trial [2] Group 2: Company Overview - Esperion Therapeutics is a commercial stage biopharmaceutical company dedicated to developing new medicines for patients with unmet needs, particularly those at risk for cardiovascular disease [3] - The company has developed the only FDA-approved oral, once-daily, non-statin medications for patients struggling with elevated LDL cholesterol [3] - Esperion's CLEAR Cardiovascular Outcomes Trial involved nearly 14,000 patients, supporting the efficacy of its treatments [3] Group 3: Future Directions - Esperion is advancing its next-generation program focused on developing ATP citrate lyase inhibitors (ACLYi), leveraging new insights for rational drug design [3][4] - The company aims to evolve into a leading global biopharmaceutical entity through commercial execution and international partnerships [4]

Company Overview - Esperion Therapeutics, Inc. is a commercial stage biopharmaceutical company focused on developing new medicines for unmet patient needs, particularly in cardiovascular disease [3] - The company has developed the only FDA-approved oral, once-daily, non-statin medications for patients with elevated low-density lipoprotein cholesterol (LDL-C) [3] - Esperion's medications are supported by the CLEAR Cardiovascular Outcomes Trial, which involved nearly 14,000 patients [3] Upcoming Events - Esperion will participate in the Cantor Global Healthcare Conference in New York on September 3, 2025, at 9:45 a.m. ET [1] - The company will also attend the H.C. Wainwright 27th Annual Global Investment Conference in New York on September 8, 2025, at 2:00 p.m. ET [1] Webcast Information - Live webcasts of the events can be accessed on the investor and media section of the Esperion website [2] - Replay of the webcasts will be available approximately two hours after the events and archived for about 90 days [2] Strategic Focus - Esperion is advancing its pre-clinical pipeline and focusing on developing ATP citrate lyase inhibitors (ACLYi) [3][4] - The company aims to leverage new insights into the structure and function of ACLYi for rational drug design, targeting the development of highly potent and specific inhibitors [3]

Company Overview - Esperion Therapeutics, Inc. is a commercial stage biopharmaceutical company focused on developing new medicines for unmet patient needs, particularly in cardiovascular disease [3] - The company has developed the only FDA-approved oral, once-daily, non-statin medications for patients with elevated low-density lipoprotein cholesterol (LDL-C) [3] - Esperion's medications are supported by the CLEAR Cardiovascular Outcomes Trial, which involved nearly 14,000 patients [3] Upcoming Financial Results - Esperion will report its second quarter 2025 financial results before the market opens on August 5, 2025 [1] - Following the financial results release, management will host a webcast at 8:00 a.m. ET to discuss the results and provide business updates [1] Business Development - The company is advancing its next-generation program focused on developing ATP citrate lyase inhibitors (ACLYi), leveraging new insights into drug design [3] - Esperion is evolving into a leading global biopharmaceutical company through commercial execution, international partnerships, and collaborations [4]

Core Insights - Esperion has appointed Craig Thompson, CEO of Cerevance, as an independent director on its Board of Directors, expanding the board to eight members [1][2]. Company Overview - Esperion Therapeutics is a commercial stage biopharmaceutical company focused on developing and marketing innovative medicines for cardiovascular disease, specifically targeting patients with elevated low-density lipoprotein cholesterol (LDL-C) [7]. - The company has developed the only FDA-approved oral, once-daily, non-statin medications for at-risk cardiovascular patients, supported by the nearly 14,000 patient CLEAR Cardiovascular Outcomes Trial [7]. Leadership Experience - Craig Thompson brings over 20 years of biopharmaceutical leadership experience, with a strong background in pharmaceutical commercialization and clinical development, which aligns with Esperion's mission [2][3]. - Prior to joining Esperion, Mr. Thompson held leadership roles at various biotechnology companies, including Cerevance, Neurana Pharmaceuticals, and Anthera Pharmaceuticals, and has experience in global marketing at Pfizer and Merck [4][5][6]. Strategic Focus - The appointment of Mr. Thompson is expected to enhance Esperion's strategic insight and operational expertise as the company aims to expand its impact in cardiovascular and cardiometabolic drug development [2][3]. - Esperion is advancing its pre-clinical pipeline and focusing on developing ATP citrate lyase inhibitors (ACLYi), which are expected to enable rational drug design and the development of highly potent inhibitors [7][8].

Core Insights - Esperion has appointed Robert E. Hoffman as an independent director and Chairperson of the Audit Committee, effective immediately and May 29, 2025, respectively [1][2] - Nicole Vitullo and Antonio M. Gotto, Jr., M.D., D. Phil. will step down from the board of directors on June 1, 2025 [1] Company Developments - Robert E. Hoffman brings extensive experience in the biopharmaceutical sector, having held leadership roles in various companies, which is expected to benefit Esperion's commercialization efforts and pipeline expansion [2][4] - The company is focused on developing next-generation ATP citrate lyase inhibitors (ACLYi) to address unmet cardiometabolic needs [5][6] Leadership Background - Mr. Hoffman has previously served as President, CEO, and CFO of Kintara Therapeutics, and held senior financial roles at Heron Therapeutics and Arena Pharmaceuticals, contributing to his expertise in commercialization [2][4] - He is also involved with several other life sciences companies and has served on various financial committees, enhancing his leadership credentials [3][4] Company Overview - Esperion is a commercial-stage biopharmaceutical company that has developed the only FDA-approved oral, once-daily, non-statin medications for patients at risk for cardiovascular disease [5] - The company aims to evolve into a leading global biopharmaceutical entity through commercial execution and international partnerships [6]