Financial Performance & Growth - Q3 2025 total revenue reached $87.3 million, a 69% year-over-year increase[10] - Q3 2025 U S net product sales were $40.7 million, a 31% year-over-year increase[10] - Retail prescription equivalents increased by 9% quarter-over-quarter[11] Market Access & Awareness - Achieved 87% Medicare and 86% commercial approval rates for NEXLETOL and NEXLIZET, with average $29/$36 copays for a 30-day supply[16] - Launched a connected-TV ad campaign on Hulu and Disney+, expected to deliver approximately 18 million impressions targeting adults 50+ with prior statin use[16] Statin Intolerance & Bempedoic Acid - Up to 30% of U S adults experience some degree of statin intolerance[18] - Approximately 29% of patients discontinue their statin within the first year[31] - In the CLEAR Outcomes trial, bempedoic acid demonstrated a 13% relative risk reduction (RRR) in the primary composite endpoint (MACE-4) compared to placebo[48] - In primary prevention patients, bempedoic acid showed a 32% RRR in MACE-4 compared to placebo[52] Clinical Trial Data - CLEAR Outcomes trial showed a 27% RRR in nonfatal myocardial infarction with bempedoic acid compared to placebo[48] - CLEAR Outcomes trial showed a 19% RRR in coronary revascularization with bempedoic acid compared to placebo[48]

Core Insights - Esperion announced acceptance of an oral and a poster presentation at the AHA Scientific Sessions 2025, highlighting ongoing research in cardiovascular health [1][2] Group 1: Presentations - The oral presentation will focus on bempedoic acid monotherapy, LDL cholesterol, and cardiovascular events, based on a secondary analysis of the CLEAR Outcomes trial [2] - A poster presentation will discuss the effects of bempedoic acid on venous thromboembolism, derived from a post-hoc analysis of the CLEAR Outcomes trial [2] Group 2: Company Overview - Esperion Therapeutics is a commercial stage biopharmaceutical company dedicated to developing new medicines for patients with unmet needs, particularly those at risk for cardiovascular disease [3] - The company has developed the only FDA-approved oral, once-daily, non-statin medications for patients struggling with elevated LDL cholesterol [3] - Esperion's CLEAR Cardiovascular Outcomes Trial involved nearly 14,000 patients, supporting the efficacy of its treatments [3] Group 3: Future Directions - Esperion is advancing its next-generation program focused on developing ATP citrate lyase inhibitors (ACLYi), leveraging new insights for rational drug design [3][4] - The company aims to evolve into a leading global biopharmaceutical entity through commercial execution and international partnerships [4]