Core Insights - Plus Therapeutics, Inc. has appointed Ron Andrews, a veteran in the diagnostics industry, to its Board of Directors, which is expected to enhance the company's strategic direction and growth in the diagnostics sector, particularly for CNSide [1][2] Company Overview - Plus Therapeutics is a clinical-stage pharmaceutical company based in Houston, Texas, focused on developing targeted radiotherapeutics for challenging cancers of the central nervous system, aiming to improve clinical outcomes [4] - The company is advancing a pipeline of product candidates, with lead programs targeting leptomeningeal metastases and recurrent glioblastoma, utilizing image-guided local beta radiation and targeted drug delivery approaches [4] Leadership and Expertise - Ron Andrews brings over 35 years of experience in the diagnostics and molecular diagnostics industry, having held leadership roles in both large organizations and successful startups, and has been instrumental in raising over $600 million in capital and leading over $15 billion in exits [2] - His connections within the global diagnostics industry are expected to help Plus Therapeutics maximize the impact of its CNSide product on patients and drive shareholder value [2] Product Development - CNSide Diagnostics, LLC, a wholly owned subsidiary of Plus Therapeutics, develops proprietary laboratory-developed tests, including CNSide, which identifies tumor cells that have metastasized to the central nervous system in patients with carcinomas and melanomas [3] - The CNSide CSF Assay Platform allows for quantitative analysis of cerebrospinal fluid, improving the management of patients with leptomeningeal metastases [3]

Core Insights - The article discusses the economic burden of late-stage leptomeningeal metastases (LM) and the potential benefits of earlier diagnosis using the CNSide assay as it approaches U.S. commercialization [1][3] Economic Impact - A health economics study indicates that earlier diagnosis and management of LM using CNSide could reduce healthcare costs by approximately 40%, primarily through earlier therapeutic intervention and reduced hospitalizations [1][7] - The analysis estimates that late-stage LM diagnosis incurs median inpatient costs of around $20,000, with total LM-related costs potentially exceeding $100,000 per month due to repeated imaging and therapies [7] Clinical Relevance - CNSide's capability to detect tumor cells in cerebrospinal fluid provides clinicians with actionable information earlier in the disease course, which is increasingly important for payers and health systems [3][4] - The study highlights the challenges in quantifying LM costs due to claims bundling with primary cancer treatment [7] Presentation Details - The findings will be presented at the ISPOR 2026 Annual Meeting, a key conference for health economics and outcomes research, scheduled for May 17-20, 2026, in Philadelphia, PA [2][4] Company Overview - Plus Therapeutics, Inc. is focused on developing precision diagnostics and radiopharmaceuticals for CNS cancers, with a pipeline that includes CNSide and REYOBIQ, a novel injectable radiotherapy [1][10] - CNSide Diagnostics, LLC, a subsidiary of Plus Therapeutics, develops tests to identify tumor cells that have metastasized to the CNS, enhancing patient management for leptomeningeal metastases [9]

Corporate Update January 2026 Power and precision in cancer radiotherapeutics NASDAQ: PSTV Cautionary Note Regarding Forward Looking Statements This presentation contains statements that may be deemed "forward-looking statements" within the meaning of U.S. securities laws, including statements regarding clinical trials, expected operations and upcoming developments. All statements in this presentation other than statements of historical fact are forward-looking statements. These forward-looking statements m ...

Core Insights - Plus Therapeutics is focused on scaling up the commercialization of CNSide and preparing for pivotal trials of REYOBIQ in 2026 [2][6] Company Overview - Plus Therapeutics, Inc. is a clinical-stage pharmaceutical company based in Houston, Texas, developing targeted radiotherapeutics for challenging CNS cancers [10] - The company aims to enhance clinical outcomes through a combination of image-guided local beta radiation and targeted drug delivery [10] Clinical Programs - REYOBIQ (rhenium Re186 obisbemeda) is a novel injectable radiotherapy designed for CNS tumors, with potential advantages over existing therapies [6] - The REYOBIQ clinical program includes trials for recurrent glioblastoma, leptomeningeal metastases, and pediatric brain cancer [6][8] - The ReSPECT-LM trial is expected to report data in Q3 2026, while the ReSPECT-GBM trial aims to complete enrollment and align with the FDA on pivotal trial design by Q4 2026 [7] Financial Updates - The company recently completed a $15 million offering to support its core business areas and extend its cash runway through 2027 [2] - Plus Therapeutics aims to cover 150 million US lives under various commercial payor agreements and achieve over 1,250 tests per year in commercial orders [7] CNSide Diagnostics - CNSide Diagnostics, a subsidiary of Plus Therapeutics, develops proprietary tests to identify tumor cells in the CNS, improving management for patients with leptomeningeal metastases [9]

Core Insights - Plus Therapeutics is set to present the final results of its ReSPECT-LM clinical trial at the SNO/ASCO CNS Metastases Conference, highlighting the safety and efficacy of its treatment for leptomeningeal metastases [1][2] - The company will also host an educational symposium focusing on advancements in managing leptomeningeal metastases, featuring presentations from leading neuro-oncologists [3] Company Overview - Plus Therapeutics, Inc. is a clinical-stage pharmaceutical company based in Houston, Texas, specializing in targeted radiotherapeutics for central nervous system cancers [8] - The company is advancing a pipeline of product candidates, particularly in the areas of leptomeningeal metastases and recurrent glioblastoma, utilizing image-guided local beta radiation and targeted drug delivery [8] Product Information - REYOBIQ (rhenium Re186 obisbemeda) is a novel injectable radiotherapy developed by Plus Therapeutics, designed to deliver targeted high-dose radiation to CNS tumors [6] - REYOBIQ is currently being evaluated in clinical trials for recurrent glioblastoma, leptomeningeal metastases, and pediatric brain cancer, with significant funding support from various institutions [6] Industry Context - Leptomeningeal metastases are a severe complication of advanced cancer, occurring in approximately 5% of metastatic cancer patients, with limited effective treatment options available [5] - The median survival for patients with leptomeningeal metastases is typically between 2 to 6 months, underscoring the urgent need for novel therapies [5]