Core Insights - Charles River Laboratories International, Inc. (CRL) is set to report its fourth-quarter 2025 results on February 18, with adjusted earnings per share (EPS) of $2.43 in the last quarter exceeding the Zacks Consensus Estimate by 4.74% [1] Financial Estimates - The Zacks Consensus Estimate for CRL's revenues is $985.9 million, indicating a 1.7% decline from the previous year [2] - The Zacks Consensus Estimate for EPS is $2.33, reflecting a 12.4% year-over-year decrease [2] Performance and Trends - Earnings estimates have remained unchanged over the past 30 days, with a consistent performance noted in the previous quarters [3] - The RMS segment is expected to see a 0.5% revenue increase in Q4 2025, driven by large research model product revenues, particularly from Noveprim and GEMS [8] Collaborations and Revenue Drivers - CRL engaged in collaborations with Toxys and X-Chem, which may positively impact revenues through enhanced service offerings [4][5] - Despite NIH budget cuts, revenues from academic and government clients are anticipated to remain favorable, although early-stage biotech demand may be constrained by funding challenges [7] Segment Performance - The Discovery and Safety Assessment (DSA) segment is projected to experience a 3.9% revenue decline year-over-year due to budget pressures from biopharmaceutical clients [11] - The Manufacturing Solutions segment is expected to benefit from strong performance in the Microbial Solutions business, with a projected revenue increase of 2.3% year-over-year [12][14] Market Position and Outlook - CRL's overall pricing environment is expected to remain stable, but the DSA segment may face challenges impacting overall revenues [11] - The company has a Zacks Rank of 3, indicating a hold position, with an Earnings ESP of -0.46%, suggesting a lower likelihood of beating estimates [15]