Core Viewpoint - Lexaria Bioscience Corp. has achieved a significant milestone by securing a total of 60 valid patents globally, enhancing its intellectual property portfolio and positioning itself for future commercial opportunities [1][9]. Patent Developments - The company has successfully obtained 6 new patents since its last update on October 9, 2025, indicating a proactive approach to intellectual property development [2]. - In Patent Family 20, Lexaria received its first patent in Australia for sublingual delivery of nicotine, complementing existing patents in the US, Canada, and Japan [3]. - The company has also secured its first European Union patent in Patent Family 21 for treating hypertension, which is significant given that Europe is the second-largest hypertension market globally [4]. - In Patent Family 24, Lexaria has strengthened its position with 2 new Australian patents and 1 new European Union patent for treating epilepsy, bringing the total to 6 US patents, 4 Australian patents, and 1 European Union patent [5]. - Additionally, in Patent Family 27, Lexaria has received 1 new US patent for treating diabetes, now holding 2 US patents in this family, which is crucial due to recent successes in the GLP-1 sector [6]. Research and Development - Lexaria's innovations are supported by a rigorous process that includes research, animal and human testing, and subsequent patent applications, allowing the company to pursue commercial relationships post-patent grants [7]. Shareholder Engagement - The company is reminding shareholders to vote in the upcoming Annual Meeting scheduled for January 27, 2026, emphasizing the importance of shareholder participation [8][10].

Core Insights - Lexaria Bioscience Corp. has released additional data from its Phase 1b clinical study GLP-1-H24-4, which focuses on the efficacy of its DehydraTECH™ technology compared to Rybelsus® [1][2] Secondary Efficacy Parameters - At week 16, the DHT arms showed no statistically significant differences compared to the Rybelsus® control in mean fasting glucose, cholesterol, and LDL cholesterol [3] Body Composition - The DHT-semaglutide arm showed a modest reduction in fat mass of -1.08 kg and total mass of -1.40 kg, while the Rybelsus® control arm achieved greater reductions of -3.55 kg in fat mass and -5.36 kg in total mass, with a higher reduction in lean mass of -1.72 kg [4] Blood Pressure Analyses - The DHT-CBD arm achieved significant reductions in blood pressure, with a mean change of -4.6 mmHg in systolic and -4.0 mmHg in diastolic blood pressure at week 4 [5][6] Pharmacokinetic Exploratory Analyses - Plasma CBD concentrations were quantifiable through week 16 in the DHT-CBD arms, while semaglutide concentrations were not quantifiable due to assay issues, although preliminary tests indicated measurable levels [8] Health Survey Results - Participants in the DHT-semaglutide arm reported mean improvements of over 5 points in physical components and over 3 points in mental components of the SF-36 health survey, compared to modest improvements in the Rybelsus® control arm [9][10] Overall Conclusions and Next Steps - The study met its primary endpoint, demonstrating good safety and tolerability of all DHT test articles, with positive findings across various parameters compared to Rybelsus® [11] Future Plans - Lexaria plans to pursue further clinical testing with a DHT + SNAC + semaglutide composition and is in discussions with a pharmaceutical company regarding the dataset from the study [15][17][18]

Core Viewpoint - Lexaria Bioscience Corp. has successfully closed a registered direct offering of 2,661,600 shares of common stock at a price of $1.315 per share, alongside a concurrent private placement of unregistered warrants to purchase the same number of shares at an exercise price of $1.19 per share [1][2]. Group 1: Offering Details - The total gross proceeds from the offering amount to approximately $3.5 million, before deducting fees and expenses [2]. - The shares were offered under a "shelf" registration statement that became effective on January 30, 2025, and the offering was conducted via a prospectus [3]. - The warrants issued in the private placement are immediately exercisable and will expire five years from the effectiveness of the resale registration statement [1][4]. Group 2: Use of Proceeds - The net proceeds from the offering are intended to advance research and development efforts, fund working capital, and support other general corporate purposes [2]. Group 3: Company Overview - Lexaria operates a patented drug delivery platform called DehydraTECH™, which enhances the absorption of various drugs through oral delivery [6]. - The company holds a robust intellectual property portfolio with 56 patents granted and additional patents pending worldwide [7].

Core Viewpoint - Lexaria Bioscience Corp. has announced a definitive agreement for a registered direct offering of 2,661,600 shares of common stock at a price of $1.315 per share, along with a concurrent private placement of unregistered warrants to purchase the same number of shares at an exercise price of $1.19 per share [1][2]. Group 1: Offering Details - The total gross proceeds from the offering are expected to be approximately $3.5 million before deducting fees and expenses [2]. - The offering is being conducted under a "shelf" registration statement that was declared effective by the SEC on January 30, 2025 [3]. - The warrants will be immediately exercisable and will expire five years from the effectiveness of the resale registration statement [1]. Group 2: Use of Proceeds - The net proceeds from the offering are intended to advance research and development efforts, fund working capital, and cover other general corporate purposes [2]. Group 3: Company Background - Lexaria Bioscience Corp. specializes in drug delivery platforms, particularly its patented DehydraTECH™ technology, which enhances the absorption of drugs through oral delivery [6][7]. - The company holds a robust intellectual property portfolio with 56 patents granted and additional patents pending worldwide [7].

Core Insights - Lexaria Bioscience Corp. has extended its Material Transfer Agreement (MTA) with PharmaCO until April 30, 2026, to allow for the review of data from an Australian study [2][3] - The MTA enables continued collaboration and strategic planning discussions between Lexaria and PharmaCO's clinical development team [2] - Lexaria's DehydraTECH™ technology aims to enhance drug delivery through oral administration, improving bio-absorption and reducing side effects [4] Summary by Sections Material Transfer Agreement Update - The MTA originally signed on September 4, 2024, has been extended to accommodate PharmaCO's review of Lexaria's Australian study data [2] - This extension allows both parties to maintain their relationship and keep the temporary exclusive license active [2] Pre-Clinical Studies and Future Expectations - Initial pre-clinical studies examining pharmacokinetics in animals have been completed [3] - Lexaria is awaiting PharmaCO's review of safety, pharmacokinetic, and efficacy data from its independent Australian human clinical study, with final results expected by the end of Q4 2025 [3] About Lexaria and DehydraTECH - DehydraTECH™ is a patented drug delivery platform that enhances the absorption of various drugs through oral delivery [4] - Lexaria holds a strong intellectual property portfolio with 54 patents granted and additional patents pending globally [4]

As filed with the Securities and Exchange Commission on October 14, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form S-1 UNDER THE SECURITIES ACT OF 1933 LEXARIA BIOSCIENCE CORP. (Exact Name of Registrant as Specified in its Charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) Nevada 2000 20-2000871 (I.R.S. Employer Identification No.) 100-740 McCurdy Road Kelowna, British Colum ...

Core Points - Lexaria Bioscience Corp. has closed a registered direct offering of 2,666,667 shares at a price of $1.50 per share, raising approximately $4.0 million before expenses [1][3] - The company also issued unregistered warrants for the purchase of an equal number of shares at an exercise price of $1.37, which are immediately exercisable and expire in five years [1][2] - The financing aims to enhance Lexaria's options for its 2026 R&D and business development plans, focusing on executing research initiatives that drive intellectual property and shareholder value [2] Financial Details - The gross proceeds from the offering were approximately $4.0 million, which will be used for working capital and general corporate purposes [3] - The shares were offered under a "shelf" registration statement effective since January 30, 2025, and the offering was conducted in compliance with SEC regulations [4] Warrants and Securities - The warrants were issued in a private placement and are not registered under the Securities Act, limiting their sale in the U.S. without an effective registration statement [5] - The company emphasizes that the offering does not constitute an offer to sell or solicit any offers to buy the securities in jurisdictions where such actions would be unlawful [6] Technology and Intellectual Property - Lexaria's DehydraTECH™ platform enhances drug delivery through oral administration, improving bio-absorption and reducing side effects [7] - The company holds a robust intellectual property portfolio with 50 patents granted and additional patents pending worldwide [7]

Core Points - Lexaria Bioscience Corp. has entered into a definitive agreement to sell 2,666,667 shares of common stock at a price of $1.50 per share in a registered direct offering [1] - Concurrently, the company will issue unregistered warrants to purchase an additional 2,666,667 shares at an exercise price of $1.37 per share, which will be immediately exercisable and expire in five years [1] - The total gross proceeds from the offering are expected to be approximately $4.0 million before deducting fees and expenses [2] Offering Details - The shares are being offered under a "shelf" registration statement that was declared effective by the SEC on January 30, 2025 [3] - The offering is made only by means of a prospectus, which will be filed with the SEC and available on their website [3] - The warrants are issued in a private placement and have not been registered under the Securities Act, limiting their sale in the U.S. [4] Company Overview - Lexaria's DehydraTECH™ technology enhances drug delivery through oral administration, improving bio-absorption and reducing side effects [6] - The company holds a robust intellectual property portfolio with 50 patents granted and additional patents pending worldwide [6]

Core Insights - The study conducted by Lexaria Bioscience Corp. indicates that the DehydraTECH processing of semaglutide enhances its brain biodistribution compared to conventional formulations, potentially improving safety and efficacy [1][3][6] Study Findings - The primary objective of the study was to assess whether DehydraTECH processing significantly improves the biodistribution of semaglutide [2] - The DehydraTECH-FTS composition showed a higher apparent trend in brain biodistribution across all tested doses, with the 5mg DehydraTECH-FTS achieving greater brain semaglutide fluorescent signal intensity than the 15mg Rybelsus® equivalent [3][5] - Fluorescent imaging revealed that all three DehydraTECH doses tested had higher fluorescence in key brain regions compared to naïve and vehicle groups, while only the highest dosage of Rybelsus® surpassed these groups [5] Mechanism and Implications - The study suggests that enhanced brain biodistribution may be linked to the pharmacodynamic performance of GLP-1 drugs, which are known to interact with brain neurochemistry [6][7] - Semaglutide's ability to regulate body weight through GLP-1 receptor activation in the brain could lead to appetite suppression without common side effects like nausea [6] - Lexaria's findings may support the development of safer and more effective GLP-1 drugs in the future [8] Research Methodology - The preclinical pilot study involved Sprague Dawley rats and utilized non-invasive whole-body imaging and ex vivo organ analysis to evaluate the biodistribution of oral semaglutide [9][12] - A total of 25 male rats were used, with 22 allocated for dosing and 3 as untreated controls, examining both DehydraTECH and Rybelsus® equivalent compositions [12][13] Technology Overview - DehydraTECH is a patented drug delivery platform that enhances the absorption and effectiveness of various drugs, including those that cross the blood-brain barrier [14]

Core Viewpoint - Lexaria Bioscience Corp. will participate in the 27th Annual H.C. Wainwright Global Investment Conference from September 8th to September 10th, 2025, highlighting its innovative drug delivery technology, DehydraTECH [1][3]. Company Overview - Lexaria Bioscience Corp. is a global innovator in drug delivery platforms, focusing on improving the way drugs enter the bloodstream through oral delivery [1][3]. - The company operates a licensed in-house research laboratory and holds a strong intellectual property portfolio with 50 patents granted and additional patents pending worldwide [3]. Technology Highlights - DehydraTECH™ is Lexaria's patented drug delivery formulation and processing platform that enhances bio-absorption, reduces side effects, and improves drug delivery across the blood-brain barrier [3].