Core Insights - Charles River Laboratories International, Inc. (CRL) reported third-quarter 2025 adjusted earnings per share (EPS) of $2.43, a decrease of 6.2% year over year, but exceeded the Zacks Consensus Estimate by 4.74% [1][8] - The company’s total revenues for Q3 reached $1.00 billion, surpassing the Zacks Consensus Estimate by 2.06%, although this represented a 0.5% decline from the previous year [2][8] - CRL narrowed its 2025 revenue guidance following mixed segment results and margin contraction, now expecting total revenues to decline between 1.5% and 0.5% [9][10] Revenue Performance - Revenues from the Research Models and Services (RMS) segment totaled $213.5 million, reflecting a year-over-year increase of 7.9% [3] - The Discovery and Safety Assessment (DSA) segment reported revenues of $600.7 million, down 2.3% year over year, attributed to lower sales volume [4] - Manufacturing Solutions generated revenues of $190.7 million, a decrease of 3.1% year over year, primarily due to lower revenues in the CDMO and Biologics Testing businesses [5] Margin and Profitability - Gross profit for the quarter was $338.8 million, down 2.9% from the prior year, with a gross margin of 33.7%, which fell by 85 basis points [6] - Selling, general & administrative expenses decreased by 10.8% year over year to $177.6 million, while adjusted operating profit increased by 7.6% to $161.2 million, leading to an adjusted operating margin expansion of 121 basis points to 16% [6] Liquidity Position - At the end of Q3 2025, CRL had cash and cash equivalents of $207.1 million, an increase from $182.8 million at the end of Q2 [7] - Cumulative net cash provided by operating activities was $590.1 million, compared to $575.2 million a year ago [7] Future Outlook - The company expects adjusted EPS for 2025 to be in the range of $10.10-$10.30, slightly up from the previous estimate of $9.90-$10.30 [10] - Management noted stable demand across its portfolio of early-stage research and manufacturing products, indicating potential for recovery, though improvements may take time [12]