Core Viewpoint - The article highlights the development of the FAIMS-TIMS-MS system by the Ningbo University Mass Spectrometry Research Institute, which significantly enhances structural resolution for biological molecule characterization, achieving over 6500 resolution, a 30-fold improvement over current international standards [3][6]. Group 1: System Development - The FAIMS-TIMS-MS system combines a high-resolution, high-sensitivity racetrack FAIMS analyzer with the Bruker timsTOF Pro 2 MS, marking a significant advancement in mass spectrometry technology [3]. - The research team, led by Professor Tang Keqi and Professor Yu Jiancheng, published their findings in the journal Analytical Chemistry, showcasing the system's capabilities [3][6]. Group 2: Performance Metrics - The FAIMS-TIMS-MS system can separate nearly 30 isomers, compared to conventional IMS instruments that can only detect one isomer and FAIMS that can detect six [6]. - The structural resolution of the new system exceeds 6500, representing a 30-fold increase compared to traditional FAIMS and TIMS technologies [6]. Group 3: Recognition and Impact - The achievement has been recognized as an excellent case in the 2024 Scientific Instrument Excellent Case Collection in China, underscoring its significance in the field [6][7]. - The first author, Assistant Researcher Li Junhui, has been actively involved in high-resolution ion mobility spectrometry research, contributing to multiple publications in international journals [9].