In a New England Journal of Medicine Oped, 12 former FDA commissioners are sounding the alarm on FDA vaccine coordinator Dr. . Venet Prasad's imposing of sweeping changes to how the US handles vaccinations. Joining us now, a former FDA commissioner and CNBC contributor Dr.. Scott Gotautle. He's on the boards of Aluminina, Fizer, and United Health. He's also one of the co-authors of the OpEd.And doctor, just get get it out of the way. I people are going to say, "Oh, yeah, gee, a Fiser guy is is promoting vac ...

Group 1 - Merck & Co., Inc. has been upgraded by Wells Fargo to Overweight from Equal Weight, with a new price target of $125, up from $90, due to recent business developments and pipeline advancements [2] - The company is entering a "catalyst-rich period" over the next 12–18 months, with multiple pipeline readouts expected, positioning it well to offset the anticipated loss of exclusivity for Keytruda [2] - Merck announced an acquisition of Cidara Therapeutics for approximately $9.2 billion, aimed at diversifying its portfolio ahead of Keytruda's patent expiration [3] Group 2 - Merck's management estimates that its 20-drug developmental pipeline could generate up to $50 billion in annual revenue at peak, with full realization expected by the mid-2030s [4] - The company has increased its quarterly dividend by 4.9% to $0.85 per share, marking the 15th consecutive year of dividend growth [4] - Merck is recognized for its strong oncology portfolio and also produces treatments for diabetes, an HPV vaccine, and a chickenpox vaccine [5]

Cervical Cancer Burden and Global Impact - Cervical cancer is the fourth leading cause of cancer and cancer deaths in women worldwide, with 660,000 cases and 350,000 deaths annually [4] - Over the past 50 years, vaccines have saved 154 million (154,000,000) lives globally, equating to 6 lives every minute [8] - Vaccines have contributed to a 40% decline in child mortality and have gifted 102 billion (10,200,000,000) years of healthy life [9][10] - In Nepal, cervical cancer is the number one cause of cancer deaths in women [16] HPV Vaccine and Prevention Strategies - HPV (Human Papilloma Virus) infection causes more than 90% of cervical cancer cases [4] - HPV vaccine is most effective when administered to girls between 9 and 14 years of age, before the start of sexual activity, with a single shot providing 95-98% protection [6] - WHO recommends a 90-70-90 strategy: 90% of girls under 15 vaccinated, 70% of women screened by 35 and again by 45, and 90% of those with cervical cancer treated [18][19] Nepal's Immunization Program and HPV Vaccine Rollout - Nepal's immunization program is recognized globally, with certifications for polio-free status, rubella and congenital rubella syndrome control, hepatitis B control, and maternal and neonatal tetanus elimination [14] - In Nepal, a campaign successfully vaccinated 1.4 million (1,400,000) eligible girls with the HPV vaccine within 2 weeks [23] - Disinformation and fake news on social media posed a challenge, requiring proactive fact-checking and counter-messaging [25][27]

Vaccination Trends - Child-immunisation programmes across Britain have experienced a decline in vaccination rates [1] - The HPV vaccination program has seen the most significant drop in rates, despite clear scientific evidence supporting its effectiveness [1]

Summary of Key Points from the Conference Call Industry Overview - **Industry Focus**: The conference call primarily discusses the healthcare sector in China, particularly the medical technology (Medtech), in vitro diagnostics (IVD), retail pharmacies, hospitals, vaccines, and insulin markets [1][2]. Core Insights and Arguments Medtech - **Key Areas of Focus**: 1. Progress of capital equipment value-based procurement (VBP) and the trade-in policy [1] 2. Channel destocking trends [1] 3. Import substitution trends post-VBP, including intraocular lenses (IOLs) and IVD [1] - **VBP Impact**: The June bidding value data showed a year-on-year growth rate of 49%, but a month-on-month decline of 3%, indicating lower unit prices due to VBP [10]. IVD Market - **Weak Demand**: The IVD sector continues to face challenges, with a projected 20% year-on-year decline in the CLIA reagent market size for 2025 [19]. - **AmoyDx Performance**: AmoyDx is expected to grow against the trend due to its strong presence in compliant in-hospital sales channels, benefiting from the anti-corruption campaign [21]. Insulin Market - **Domestic Substitution**: The insulin industry has seen significant growth, particularly for insulin analogs from companies like Gan & Lee and THDB, which reported rapid revenue growth in 1Q25 [22]. Retail Pharmacies - **Market Pressure**: Retail pharmacies are under pressure due to strict reimbursement policies and weak consumer spending. However, there is a potential market-clearing trend expected by year-end [31]. Hospitals - **New Product Feedback**: Hospitals are seeing new product introductions, such as the new version of SMILE surgery and new PIOL products, which are expected to drive consumption recovery [1]. Vaccine Market - **Anti-Corruption Campaign**: The ongoing anti-corruption campaign within the CDC system is impacting vaccine demand and distribution channels [1]. Financial Performance and Estimates Earnings Revisions - **Mindray**: Annual earnings estimates revised down by 2.1% to 5.0% for 2025E-27E due to industry headwinds in medical equipment and IVD [2][37]. - **United Imaging**: Revenue and earnings forecasts adjusted down to reflect lower-than-expected bidding data [39]. - **SNIBE**: Earnings estimates revised down by 1.4% to 7.1% for 2025E-27E due to policy headwinds in the IVD sector [40]. Revenue Growth Expectations - **High Growth Companies**: THDB and Gan & Lee are expected to achieve the highest revenue growth due to a low base from VBP renewal in 2Q24 [6]. - **Mindray's Decline**: Mindray's China business is expected to decline by 26% year-on-year in 2Q25 due to IVD weakness [9]. Other Important Insights - **Trade-in Policy Concerns**: The trade-in stimulus fund is expected to run out, leading to a decline in applications and a reduced stimulus effect in the second half of 2025 [10]. - **Market Dynamics**: The healthcare market is experiencing a shift with increasing government support for procurement and a focus on innovative products [47][48]. Conclusion - The healthcare sector in China is facing various challenges, including policy headwinds, weak demand in certain segments, and the impact of ongoing reforms. However, there are also opportunities for growth, particularly in innovative products and domestic substitution trends. Companies like AmoyDx, Gan & Lee, and THDB are positioned to benefit from these trends, while others like Mindray and SNIBE are facing headwinds that may impact their performance in the near term.