We recently compiled a list of the 20 Best Biotech Stocks Under $20 to Buy Now. One of the twenty stocks on our list of best biotech stocks is Kura Oncology, Inc. TheFly reported on January 13 that Leerink Partners lowered the price target on KURA to $20 from $25 and maintained an Outperform rating. This revision reflects updates to the model incorporating preliminary Q4 financial results, which include Komzifti’s net product revenue, collaboration revenue, and 2026 guidance ahead of the company’s Q4 earn ...

Core Insights - Several biotechnology and life sciences companies experienced significant gains in after-hours trading, indicating strong investor interest in recent clinical and corporate developments [1] Company Summaries - Kura Oncology, Inc. (KURA) saw its shares rise to $10.57, an increase of 7.42% (+0.73), likely due to positive investor sentiment following the announcement of new data from its KOMET-007 Phase 1a/1b trial, which showed a favorable safety profile and encouraging antileukemic activity for its treatment regimen in acute myeloid leukemia patients [2] - SOPHiA GENETICS SA (SOPH) closed after hours at $4.85, gaining 5.21% (+0.24), with continued investor interest stemming from its collaboration with Complete Genomics to co-market precision oncology testing solutions [3] - Elutia Inc. (ELUT) experienced modest gains, with shares rising to $0.6045, up 3.10% (+0.0182), reflecting steady investor interest in the micro-cap biotech sector [4] - RenovoRx, Inc. (RNXT) added 2.47% (+0.02) to close at $0.9530, with recent news of its abstract submission acceptance for the ASCO Gastrointestinal Cancers Symposium 2026, where it will present findings from its ongoing Phase III trial [5] - Kodiak Sciences Inc. (KOD) posted a notable gain, climbing to $27.41, up 5.42% (+1.41), following the successful closing of a public offering that generated approximately $184 million in gross proceeds [6] - Day One Biopharmaceuticals, Inc. (DAWN) rose to $9.55, gaining 3.35% (+0.31), continuing to attract investor attention focused on oncology innovation [7] - Quantum BioPharma Ltd. (QNTM) advanced to $9.23, up 3.82% (+0.34), following the closing of a non-brokered private placement that raised gross proceeds of $750 [8]

Group 1 - Kura Oncology, Inc. is focused on developing targeted cancer therapies for genetically defined leukemias and solid tumors, with several drug candidates in clinical development [2] - The company received FDA approval for KOMZIFTI, a once-daily oral targeted therapy for adults with relapsed or refractory NPM1-mutated acute myeloid leukemia [2] - Early trial results for KOMZIFTI combined with venetoclax and azacitidine showed overall response rates of 65% and 41% in relapsed/refractory NPM1-m and KMT2A-r AML, with higher rates in venetoclax-naïve patients [2] Group 2 - Kura Oncology is noted for its milestone payment of $135 million related to the U.S. commercial sale of KOMZIFTI, indicating significant commercial potential [1] - The company is viewed as a speculative investment in the cancer treatment space, with larger competitors like Johnson & Johnson and Merck being ahead in the market [1] - Despite the potential of Kura Oncology, certain AI stocks are suggested to offer greater upside potential and less downside risk [2]

Core Viewpoint - Kura Oncology Inc. is expected to see significant stock growth, with Barclays raising its price target to $28 from $11, driven by the approval of ziftomenib [1] Group 1: Company Overview - Kura Oncology is a clinical-stage biopharmaceutical company focused on developing cancer treatments [4] Group 2: Product Approval - The US FDA granted full approval to KOMZIFTI (ziftomenib) for treating adult patients with relapsed or refractory acute myeloid leukemia (AML) with a susceptible NPM1 mutation [2] - KOMZIFTI is the first and only once-daily oral menin inhibitor approved for AML, which affects approximately 30% of AML cases [2] Group 3: Clinical Trial Data - The approval of KOMZIFTI is supported by data from the pivotal KOMET-001 trial involving 112 R/R NPM1-mutated AML patients, showing a combined complete remission rate of 21.4% [3] - The safety profile of KOMZIFTI is favorable, with no Boxed Warning for QTc prolongation or Torsades de Pointes, allowing for easier co-administration with other medications [3]

Core Insights - The combination of ziftomenib with venetoclax and azacitidine shows promising clinical activity in treating acute myeloid leukemia (AML) with NPM1 mutations and KMT2A rearrangements, with high rates of complete remission and molecular negativity [2][3][8] Group 1: Clinical Efficacy - In newly diagnosed NPM1-m AML, 86% achieved composite complete remission (CRc) and 73% achieved complete remission (CR), with 68% of CRc responders attaining molecular minimal residual disease (MRD) negativity [1][2] - In relapsed/refractory (R/R) NPM1-m AML, the overall response rate (ORR) was 65%, and in venetoclax-naïve patients, the ORR was 83% [1][2] - For R/R KMT2A-r AML, the ORR was 41%, with 70% in venetoclax-naïve patients [1][2] Group 2: Safety Profile - The triplet combination of ziftomenib, venetoclax, and azacitidine was well tolerated, with low rates of ziftomenib-related myelosuppression and no increase in toxicity beyond venetoclax/azacitidine alone [1][4][7] - Adverse reactions included differentiation syndrome and QTc prolongation, but these were managed without treatment discontinuation [4][7] Group 3: Ongoing Development - Kura Oncology is conducting registrational trials for ziftomenib in both intensive chemotherapy-eligible and -ineligible patients [1][2][8] - The ongoing KOMET-007 Phase 1a/1b trial is evaluating ziftomenib's efficacy across multiple AML subtypes, reinforcing its potential as a foundational treatment option [1][8][12] Group 4: Company Information - Kura Oncology is focused on precision medicines for cancer treatment, with KOMZIFTI (ziftomenib) being the first oral menin inhibitor approved for adult patients with R/R AML harboring NPM1 mutations [12][28] - Kyowa Kirin collaborates with Kura Oncology, emphasizing their commitment to innovative treatments for high unmet medical needs [29]