Financial Performance - Novartis Q3 2025 net sales reached USD 13909 million, a 7% increase in constant currencies compared to Q3 2024[19, 108] - Core operating income also grew by 7% in constant currencies, reaching USD 5460 million in Q3 2025[19, 108] - The core margin was 393% in Q3 2025[19, 108] - Free cash flow for 9M 2025 was USD 15941 million, a 26% increase compared to 9M 2024[108, 112] - The company reaffirms its 2025 full-year guidance, expecting high single-digit sales growth and low-teens core operating income growth in constant currencies[20, 119, 120] Key Products Growth - Kisqali experienced a 68% growth in constant currencies during Q3[25, 27] - Kesimpta sales increased by 44% in constant currencies in Q3[25, 40, 41] - Pluvicto sales grew by 45% in constant currencies in Q3[25, 47, 48] - Scemblix sales increased by 95% in constant currencies in Q3[25, 67, 68] - Leqvio sales grew +54% cc in Q3[60, 61] Pipeline and Innovation - Rhapsido received FDA approval for Chronic Spontaneous Urticaria (CSU)[22, 88] - Ianalumab showed positive Phase III results in Sjögren's Disease (SjD)[22, 93] - Pluvicto's PSMAddition trial demonstrated a 28% reduction in risk of progression or death in PSMA+ mHSPC patients[54, 59]

Core Insights - ITM Isotope Technologies Munich SE has elected Dr. Barbara Weber to its Supervisory Board, effective May 01, 2025, enhancing the board's expertise in advancing its radiopharmaceutical pipeline [1][2] - Dr. Weber brings over 25 years of experience in biotech and pharmaceutical industries, having held leadership roles at major companies and founded Tango Therapeutics [1][4] - The company is focused on developing its lead Phase 3 candidate, n.c.a. 177Lu-edotreotide (ITM-11), and expanding its pipeline of radiopharmaceuticals [1][3] Company Overview - ITM is a leading radiopharmaceutical biotech company dedicated to developing therapeutics and diagnostics for hard-to-treat tumors, aiming to improve patient outcomes through precision oncology [5] - The company has a broad pipeline that includes multiple Phase 3 studies, leveraging high-quality radioisotopes combined with various targeting molecules [5] Leadership and Expertise - Dr. Weber's background includes significant achievements in oncology drug development, including leading clinical studies that resulted in FDA approvals for several drugs [4] - As a physician-scientist, Dr. Weber emphasizes the potential of targeted radiopharmaceutical therapy to enhance precision oncology treatment [3]