Core Insights - Charles River Laboratories International, Inc. (CRL) is set to report its third-quarter 2025 results on November 5, with adjusted earnings per share (EPS) of $3.12 in the last quarter exceeding the Zacks Consensus Estimate by 24.80% [1] Q3 Estimates - The Zacks Consensus Estimate for CRL's revenues is $984.6 million, indicating a 2.5% decline from the previous year [2] - The Zacks Consensus Estimate for EPS is $2.32, reflecting a 10.4% year-over-year decrease [2] Estimate Revision Trend - Earnings estimates for CRL's third quarter have decreased by 1 cent in the past week [3] Factors Impacting Performance - **Research Models and Services (RMS)**: Expected revenue growth of 6.5% in Q3 2025, driven by strong sales in research model services and favorable pricing, particularly in the GEMS and Insourcing Solutions businesses [4][5] - **Discovery and Safety Assessment (DSA)**: Anticipated revenue decline of 7% due to budget pressures from biopharmaceutical clients and cash constraints faced by smaller biotech firms [6][8] - **Manufacturing Solutions**: Projected revenue drop of 0.6% in Q3 2025, influenced by geopolitical tensions and supply chain disruptions, although the Microbial Solutions business is expected to perform well [9][10] Earnings Whispers - CRL has an Earnings ESP of +0.61% and a Zacks Rank of 3, indicating a moderate chance of beating estimates [11]

Financial Performance & Guidance - Charles River's 2Q25 revenue reached $1032.1 million, a 0.6% increase year-over-year, but experienced a 0.5% organic decline[12, 36] - Non-GAAP EPS for 2Q25 was $3.12, an 11.4% increase year-over-year[14, 36] - The company is raising its revenue guidance by +150 bps to a 1%-3% decrease organically and Non-GAAP EPS by +$0.55 at midpoint to $9.90-$10.30[15] - The updated 2025 organic revenue growth guidance is a decrease of 3.0%-1.0%[16, 37] - Free cash flow for 2Q25 was $169.3 million, with FY 2025 guidance at $430-$470 million[49] Segment Performance - DSA (Discovery and Safety Assessment) revenue for 2Q25 was $618.0 million, a 1.5% decrease year-over-year, with a 2.4% organic decline[17] - RMS (Research Models and Services) revenue for 2Q25 was $213.3 million, a 3.3% increase year-over-year, with a 2.3% organic increase[26] - Manufacturing Solutions revenue for 2Q25 was $200.8 million, a 4.4% increase year-over-year, with a 2.9% organic increase[30] Demand Trends & Outlook - DSA net book-to-bill dipped back below 1x in 2Q25, to 0.82x [10] - The company now expects DSA revenue to decline at a low- to mid-single-digit rate in 2025, an improvement from the prior outlook of a mid-single-digit decline[21] - NAMs (New Approach Methodologies) portfolio generates approximately $200 million in annual DSA revenue[24]