Teva's Pipeline and Capabilities - Teva has in-house R&D experts with a proven track record in developing neuroscience products at all stages of development[15] - Teva has substantial, experienced commercial neuroscience teams[16] Schizophrenia Market and Unmet Needs - There are an estimated ~47 million prevalent schizophrenia patients in the US and Europe[35] - Approximately 23 million patients are diagnosed, and ~21 million are treated[39] - Long untreated psychosis is associated with poor long-term outcomes[21] - Suboptimal medication adherence is a major modifiable risk factor for relapse, highlighting the need for LAIs[22] Teva's Olanzapine LAI (TEV-'749) - Teva's olanzapine LAI met primary and key secondary efficacy endpoints at all 3 doses[30] - The efficacy and systemic safety profile of Teva's olanzapine LAI is comparable to daily oral olanzapine, with no PDSS to date[30] - Approximately 4,000 subcutaneous injections across multiple clinical studies, with no PDSS observed[30] - All TEV-'749 doses exhibited long-term, continuous symptom improvement and maintenance of clinical effectiveness in the SOLARIS study[59] - No suspected or confirmed PDSS events were reported in 3470 injections[59] Commercial Opportunity - Teva aims to be the preferred LAI for patients appropriate for oral risperidone or paliperidone and modestly controlled patients seeking additional convenience[34] - Teva is addressing a broad spectrum of patients with UZEDY and olanzapine LAI, with 65%-80% of patients having the potential to switch as they are currently on a similar molecule[45] - Teva anticipates franchise peak sales expectation of $15 billion-$20 billion for Olanzapine LAI TEV-'749[45]