Core Viewpoint - NetraMark Holdings Inc. has successfully closed the first tranche of a non-brokered private placement, raising gross proceeds of $3,110,000, which will be utilized for working capital and general corporate purposes [1][4]. Group 1: Private Placement Details - The first tranche involved the issuance of 3,110,000 units at a price of $1.00 per unit, with each unit consisting of one common share and one-half of a common share purchase warrant [2]. - Each warrant allows the holder to acquire an additional common share at an exercise price of $1.35 for a period of two years from the closing date [2]. - The securities issued are subject to a hold period expiring on May 28, 2026, as per applicable securities laws [3]. Group 2: Future Tranche and Financial Commitments - The company has received commitments for the second and final tranche of the private placement, expected to close soon for additional gross proceeds of $390,000 [4]. - Following the first tranche, there are now 91,778,520 common shares of NetraMark issued and outstanding [3]. Group 3: Insider Participation - Certain insiders participated in the first tranche, subscribing for a total of 2,060,000 units, which is classified as a related party transaction [5]. - The company is exempt from formal valuation and minority shareholder approval requirements due to the nature of the transaction and its market capitalization [5]. Group 4: Company Overview - NetraMark is focused on developing Generative Artificial Intelligence (Gen AI) and Machine Learning (ML) solutions for the pharmaceutical industry, utilizing a novel topology-based algorithm to analyze patient data [8]. - The company's AI technology, NetraAI, is designed to improve clinical trial success rates by effectively segmenting patient data into explainable and unexplainable subsets, addressing issues of overfitting common in other AI methods [7].

TORONTO, Jan. 13, 2026 (GLOBE NEWSWIRE) -- NetraMark Holdings Inc. (the “Company” or “NetraMark”) (CSE: AIAI) (OTCQB: AINMF) (Frankfurt: PF0), a premier artificial intelligence (AI) company transforming clinical trials with AI-powered precision analytics in the pharmaceutical industry, is pleased to announce a non-brokered private placement of up to 3,500,000 units of the Company (the “Units”) at a price of $1.00 per Unit, for aggregate gross proceeds of up to $3,500,000 CDN (the “Offering”). Each Unit will ...

Core Insights - NetraMark Holdings Inc. has made significant progress in commercial execution, regulatory engagement, and scientific validation, strengthening its growth trajectory in AI-driven clinical trial optimization [1][2] Group 1: Contract Backlog and Financial Outlook - The contract backlog for NetraMark increased to approximately C$2.5 million, driven by new project commitments and commercial momentum, with a target of reaching C$8–$10 million by mid-2026 [2][4] - The company is experiencing growing commercial traction and expanding channel partnerships, which support its financial outlook [4] Group 2: Regulatory Engagement - NetraMark completed a Critical Path Innovation Meeting (CPIM) with the FDA, receiving feedback on its NetraAI platform and its application in clinical trial design [2] - The FDA discussed considerations for identifying responder-enriched subgroups while maintaining control of Type I error, aligning with FDA enrichment guidance [2] Group 3: Scientific Validation - A scientific study on NetraAI was accepted for publication in npj Digital Medicine, demonstrating its ability to identify clinically meaningful subgroups in a Phase II depression trial [2] - The acceptance by a high-impact journal provides third-party validation of NetraMark's scientific approach [2] Group 4: Strategic Collaborations - NetraMark secured an Ontario Research Fund – Research Excellence Award in collaboration with the Centre for Addiction and Mental Health (CAMH), focusing on analyzing genetic and epigenetic data in psychiatric disorders [2] - This collaboration aims to enhance NetraAI's capabilities in identifying explainable patient subpopulations [2]

Core Insights - NetraMark Holdings Inc. has been awarded the Ontario Research Fund - Research Excellence Award in collaboration with the Centre for Addiction and Mental Health (CAMH) for their innovative partnership in advancing research and technology in mental health [1][2]. Group 1: Collaboration and Research Focus - The collaboration will utilize NetraAI, a machine learning platform, to analyze genetic and epigenetic data from studies on schizophrenia and major depressive disorder [2][3]. - The initiative aims to identify explainable patient subpopulations to clarify biological subtypes in psychiatric disorders, supporting next-generation precision treatment strategies [3]. Group 2: Technological Advancements - NetraAI is designed to separate small datasets into explainable and unexplainable subsets, enhancing the accuracy of insights derived from clinical trials [6]. - The platform's unique focus mechanisms aim to reduce the risk of overfitting, which can lead to inaccurate insights and improve the chances of clinical trial success [6]. Group 3: Impact on Clinical Trials - The collaboration is expected to enhance NetraAI's capabilities to serve pharmaceutical sponsors, ultimately improving clinical trial outcomes in the psychiatric space [3][4]. - The research will also evaluate additional datasets from the Ontario Health Insurance Plan (OHIP) to analyze cost-effectiveness and the broader health-system impact of personalized patient care [4]. Group 4: Institutional Background - CAMH is recognized as Canada's largest mental health and addiction teaching hospital, combining clinical care, research, education, and policy development to transform the lives of individuals affected by mental illness [5]. - The partnership with CAMH allows NetraMark to leverage extensive genomic and clinical datasets to explore genetic influences on treatment responses [4]. Group 5: Company Overview - NetraMark focuses on developing Generative Artificial Intelligence and Machine Learning solutions specifically for the pharmaceutical industry, utilizing a novel algorithm to parse patient data effectively [7]. - The company's approach enables accurate segmentation of diseases and classification of patients based on treatment sensitivity and efficacy [7].

Core Insights - NetraMark Holdings Inc. has completed its Critical Path Innovation Meeting (CPIM) with the FDA, discussing its AI platform, NetraAI, and its potential in clinical trial design [1][2][4] - The FDA provided feedback on NetraAI's explainable AI/ML capabilities and suggested exploring the Model-Informed Drug Development (MIDD) Paired Meeting Program for further regulatory dialogue [2][3][4] Company Overview - NetraMark is focused on developing AI and machine learning solutions for the pharmaceutical industry, utilizing a novel algorithm to analyze patient datasets effectively [6] - The company's platform, NetraAI, is designed to identify biological and clinical signatures in small datasets, enhancing the likelihood of clinical trial success [2][5] Regulatory Engagement - The CPIM with the FDA is a significant step for NetraMark, providing insights into regulatory considerations for AI in clinical development [4] - The FDA's engagement reinforces the importance of explainability and scientific rigor in AI applications for drug development [2][3] Technical Differentiation - NetraAI employs unique focus mechanisms to separate explainable and unexplainable subsets of data, addressing challenges like overfitting that can compromise trial outcomes [5] - The platform's approach allows for targeted inclusion/exclusion criteria and pre-specified stratification in trial designs, potentially improving statistical power and reducing trial risks [3][4]

Core Insights - NetraMark Holdings Inc. has secured a new contract with a global biopharmaceutical company to provide analytics support for a pivotal Phase 3 clinical trial, highlighting the company's growing influence in the pharmaceutical sector [1][2]. Group 1: Contract and Project Details - The new engagement is part of an existing master services agreement and represents a discrete project aimed at enhancing decision support in Phase 3 trials, showcasing the increasing interest in NetraAI technology [2][4]. - NetraMark will utilize its NetraAI platform to identify and characterize patient subpopulations, including responders and non-responders, which will aid in interpreting treatment response patterns and variability within the study population [3][4]. Group 2: Technology and Methodology - NetraAI is designed to separate small datasets into explainable and unexplainable subsets, which helps avoid overfitting and enhances the accuracy of insights derived from clinical trials [5][6]. - The technology's unique focus mechanisms allow for better segmentation of diseases and classification of patient responses, thereby increasing the likelihood of clinical trial success [5][6]. Group 3: Company Position and Future Outlook - The CEO of NetraMark emphasized the growing trust from biopharmaceutical companies in the value of explainable AI for high-stakes development programs, indicating a positive trajectory for the company's future engagements [4][7]. - This contract reinforces NetraMark's position in AI-powered clinical trial optimization and suggests potential for further growth as the company becomes integrated into standard operating procedures of biopharmaceutical firms [4][7].

Core Insights - NetraMark Holdings Inc. has announced the acceptance of its peer-reviewed paper on its AI platform, NetraAI, for publication in npj Digital Medicine, highlighting its advancements in clinical trial analytics [1][3] Group 1: Publication and Research Findings - The paper demonstrates how NetraAI utilizes explainable AI to identify patient subpopulations that enhance therapeutic responses in clinical trials, specifically using data from a Phase II ketamine trial for treatment-resistant depression [2][3] - The research was co-authored by experts from the National Institute of Mental Health and NetraMark, showcasing a collaborative effort in advancing AI applications in clinical settings [3] - The publication emphasizes the integration of advanced modeling techniques within NetraAI, which aims to improve clinical trial decision-making and reduce placebo effects [4] Group 2: Technology and Methodology - NetraAI is designed to differentiate between explainable and unexplainable patient subsets, addressing issues of overfitting that can lead to inaccurate insights in clinical trials [6] - The platform employs a novel topology-based algorithm that allows for effective segmentation of patient data, enhancing the accuracy of treatment efficacy assessments [7] - By focusing on smaller datasets, NetraAI aims to improve the chances of clinical trial success through better patient classification and treatment response predictions [6][7]

Core Insights - NetraMark Holdings Inc. has signed four contracts with a leading global pharmaceutical company to provide advanced AI analytics for multiple late-stage clinical studies [1][4] - The proprietary NetraAI platform will be utilized to analyze clinical data from these studies, focusing on identifying patient subpopulations that influence treatment and placebo responses [2][3] Group 1: Contract Details - The contracts represent a significant expansion of the ongoing collaboration between NetraMark and the pharmaceutical company, reflecting continued confidence in NetraMark's technology [3][4] - Each study will leverage the NetraAI system, which is designed to identify high-effect-size subgroups within complex datasets, aligning with FDA expectations for explainable AI in clinical development [3][5] Group 2: Technology Overview - NetraAI is engineered to separate small datasets into explainable and unexplainable subsets, enhancing the accuracy of insights derived from clinical data [5][6] - The technology allows for the analysis of smaller datasets while accurately classifying patients based on their sensitivity to drugs and treatment efficacy [6]

Core Insights - NetraMark Holdings Inc. has signed a contract with a leading biopharmaceutical company to utilize its NetraAI platform in a Phase 3 clinical trial for a new psychiatric medicine, indicating the company's growing influence in the pharmaceutical industry [1][2]. Company Overview - NetraMark is focused on transforming clinical trials through AI-powered precision analytics, specifically targeting the pharmaceutical sector [1][6]. - The company employs a unique topology-based algorithm that allows for effective analysis of small, complex clinical datasets, enhancing the understanding of patient heterogeneity [6]. Technology and Methodology - The NetraAI platform utilizes a dynamical systems framework to analyze multi-dimensional clinical data, identifying explainable subpopulations related to treatment responses and adverse events [2][3]. - Unlike traditional AI methods, NetraAI incorporates focus mechanisms that separate datasets into explainable and unexplainable subsets, reducing the risk of overfitting and improving the accuracy of insights [5]. Industry Impact - The engagement with the biopharmaceutical company reflects a growing recognition of the value of explainable AI in improving clinical trial success rates [3][4]. - NetraMark's technology aims to provide actionable insights that can inform regulatory and market access strategies, thereby supporting drug development success [2][4].

Core Insights - NetraMark Holdings Inc. is leveraging its AI technology, NetraAI, to enhance clinical trials in the pharmaceutical industry, particularly for major depressive disorder (MDD) [1][10] Group 1: Presentation Highlights - At the ISCTM Autumn conference and ECNP Congress, NetraMark showcased two significant applications of its technology, focusing on ketamine and escitalopram trials [1][5] - The first presentation demonstrated how NetraAI identified distinct patient responder subgroups in ketamine trials, revealing that ketamine responders had unique baseline characteristics compared to placebo responders [2][3] - The second presentation introduced a novel algorithm that improved predictive accuracy in heterogeneous MDD trials, specifically for escitalopram response, by identifying a compact feature set related to anhedonia and mood [5][6] Group 2: Key Findings - In the ketamine trial, responder subgroups diverged significantly from placebo responders by the second infusion, indicating that ketamine's efficacy is not merely due to functional unblinding [4][8] - NetraAI's analysis in the CAN-BIND trial reduced clinical variables from 718 to 8 key variables, enhancing prediction accuracy and identifying a subgroup of highly predictive responders [9][7] - The technology revealed a genetic signature linked to neuroplasticity, allowing for a 91% accuracy in predicting treatment success when retrained on specific features [17] Group 3: Implications for Clinical Trials - NetraAI's capabilities can help overcome traditional barriers in CNS drug development by improving patient stratification, reducing placebo-related noise, and enhancing predictive modeling [10][12] - The advancements in distinguishing true pharmacologic effects from placebo responses represent a significant step forward in the design and interpretation of psychiatric and CNS trials [11][12] - As precision medicine becomes increasingly important, NetraMark's innovations provide a robust toolkit for pharmaceutical companies to uncover meaningful patient subgroups and accelerate drug development timelines [12][14]