PCE (Programmable Chromosome Engineering)

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华人学者本周发表7篇Cell论文:AI挖掘代谢酶、新型类全能细胞、癌症恶病质、细胞命运调控、大片段DNA编辑等
生物世界· 2025-08-09 08:00
Group 1 - The article highlights nine research papers published in the journal Cell, with seven authored by Chinese scholars, covering various topics in biology and genetics [2] - A study on the mechano-resistance mechanism in skin adaptation to terrestrial locomotion was published, revealing insights into the SLURP1 gene and its implications for palmoplantar keratoderma [4][7] - A new programmable chromosome engineering technology (PCE) was introduced, enabling precise manipulation of DNA at kilobase to megabase scales, which could enhance crop traits and genetic disease treatments [9][12] Group 2 - Research on composite transposons revealed their role as enhancers in cell fate regulation, highlighting the significance of bivalent chromatin in hematopoietic differentiation and aging [14][17] - A study demonstrated that vagal nerve blockade can alleviate cancer-associated cachexia in mouse models, restoring appetite and extending survival [19][22] - A novel model of mouse embryogenesis was developed using chemically induced embryonic founder cells, providing new tools for studying organ development and regenerative medicine [23][26] Group 3 - A genetic history study of the Southern Caucasus revealed 5,000 years of genetic continuity despite high population mobility, based on ancient DNA analysis from archaeological sites [28][31] - An AI-assisted pipeline was created to identify gut microbial bile acid metabolic enzymes, expanding knowledge of microbial metabolism and its implications for gut health [33][36]