本周化工市场综述 本周市场震荡向上，其中申万化工指数上涨 0.8%，跑输沪深 300 指数 0.74%。标的方面，本周 AI 材料标的表现 亮眼，比如：东材科技、中材科技、长海股份，除此之外，有边际变化的标的也有较佳表现，比如：久日新材、广 信材料、国恩股份、苏利股份，当下市场会给予有边际变化以及存在新增长曲线的公司正反馈，这类风格或将继续 强化。估值方面，当前板块的赔率依然较高，其中板块 PB 历史分位数为 20%，PE 历史分位数为 71%。化工行业，主 要关注四大事件，一是本周美国商务部工业与安全局发出的一纸正式通知，终结了自 5 月底以来持续困扰中美能源 贸易市场的乙烷出口风波，万华化学和卫星化学乙烷利空解除；二是巴斯夫动物营养业务的重要产品露他维®A 1000 NXT （Lutavit® A 1000 NXT）不可抗力声明正式解除；三是国内新材料产品持续突破，包括阿科力 5000 吨 COC 正 式投产以及上海洁达尼龙材料有限公司 12 万吨/年己二胺装置一次投料开车成功；四是 SABIC 确认将永久关停位于 英国英格兰泰恩赛德地区的烯烃 6 号裂解装置，该装置乙烯年产能为 86.5 万吨，丙烯年产 ...

化学原料行业近一年市场表现 资料来源：最闻 相关报告： 补贴，推动风电行业维持高速发展-新材 料周报（250616-0620） 2025.6.24 打印新需求，核心耗材 PLA 迎来发展新 机-新材料周报（250609-0613）2025.6.17 冀泳洁 博士 执业登记编码：S0760523120002 邮箱：jiyongjie@sxzq.com 王锐 执业登记编码：S0760524090001 申向阳 邮箱：shenxiangyang@sxzq.com 新材料 新材料周报（250623-0627） 领先大市-B(维持) 工信部印发绿色低碳重要实施方案，生物航煤价格持续上涨 2025 年 7 月 3 日 行业研究/行业周报 二级市场表现 市场与板块表现：本周新材料板块上涨。新材料指数涨幅为 5.12%，跑输创 业板指 0.57%。近五个交易日，合成生物指数上涨 2.30%，半导体材料上涨 4.09%， 电子化学品上涨 5.20%，可降解塑料上涨 2.93%，工业气体上涨 3.03%，电池化 学品上涨 9.13%。 产业链周度价格跟踪（括号为周环比变化） 氨基酸：缬氨酸(14200 元/吨，0.35%)、精氨 ...

Key Takeaways GoPro launched MotionFrame and POV to enhance 360 editing in its Quik mobile app MotionFrame uses phone movement to create dynamic edits from 360 video playback. POV aligns video edits with travel direction using GPS data from the GoPro MAX cameraGoPro, Inc. (GPRO) has launched two powerful new tools—MotionFrame and POV—to enhance the 360-editing suite in its Quik mobile app. MotionFrame allows users to create dynamic edits simply by moving their phone during 360 video playbacks. Users can e ...

Jefferies Global Healthcare Conference June 5, 2025 Forward-looking Statements and Other Important Information This presentation contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding Karyopharm's beliefs about the market opportunity and annual peak revenue opportunities for selinexor; expectations with respect to commercialization efforts; the ability of selinexor to treat patients with multiple ...

SAN FRANCISCO, June 09, 2025 (GLOBE NEWSWIRE) -- FibroGen, Inc. (NASDAQ: FGEN) today announced the appointment of Dr. Michael Kauffman to its Board of Directors effective June 4, 2025. “Michael is a well-recognized biotech industry veteran, who brings a wealth of biotech leadership experience to our board,” said James Schoeneck, chairman of the board of directors of FibroGen. “His expertise spanning all stages of drug development will be invaluable as FibroGen progresses its pipeline. Michael’s deep underst ...

Summary of Incyte (INCY) FY Conference Call - June 09, 2025 Company Overview - **Company**: Incyte Corporation (INCY) - **Focus**: Oncology and other therapeutic areas with a strong emphasis on drug development and commercialization Key Points Commercial Portfolio and Revenue Growth - Incyte has expanded its commercial portfolio beyond Jakafi, with expected revenues of €650 million from ObsElura and over €400 million from oncology assets in 2025, totaling over $1 billion from products outside Jakafi this year [1][2] - Four product launches are anticipated, contributing an additional $1 billion by 2029, indicating a strong growth trajectory [2] Pipeline Developments - The company is in a pivotal year with four Phase III programs, with three readouts completed and one pending [3] - The POVO program for hidradenitis suppurativa (HS) is highlighted as significant, with positive Phase III data expected to drive future growth [3][4] Mutant KALAR Program Insights - Initial Phase I data for the mutant KALAR program shows good tolerability, with only one out of 40 patients discontinuing treatment [6][7] - The program aims to normalize platelet counts and reduce the malignant clone in patients with essential thrombocythemia (ET) [8][9] Jakafi Performance - Jakafi reported a strong Q1 with 24% year-over-year growth, driven by demand, net price adjustments, and reduced destocking [21] - The company raised its 2025 guidance to approximately 7% year-over-year growth at the midpoint, with future growth expected to be demand-driven [21][22] Opselura Sales Trajectory - Opselura is projected to generate $650 million in revenue for 2025, reflecting a 28% year-over-year growth, with contributions from both the U.S. and Europe [26] - The potential approval for pediatric atopic dermatitis (AD) is seen as a significant opportunity, targeting around 2 million children in the U.S. [28][32] POVO Commercial Strategy - Despite initial data falling short of expectations, Incyte emphasizes the positive outcomes from two Phase III trials for POVO, particularly in pain improvement for HS patients [38][39] - The company anticipates a substantial commercial opportunity with approximately 30,000 patients ready for POVO at launch [42] Pipeline Diversification - Incyte's pipeline includes a variety of therapeutic modalities, including bispecifics, traditional biologics, and small molecules, which helps mitigate risks across different therapeutic areas [46] Capital Allocation Strategy - The company prioritizes its internal pipeline and is unlikely to pursue major deals in the near term, focusing instead on early-stage technologies and near-commercial assets that can enhance revenue without significantly increasing R&D costs [54][56] Additional Insights - Compliance issues in vitiligo treatment have been addressed through educational initiatives to improve patient adherence to therapy [33][34] - The company is optimistic about the potential of its pipeline to redefine treatment approaches for various malignancies, particularly in myeloproliferative neoplasms [48][49] This summary encapsulates the key discussions and insights from Incyte's FY conference call, highlighting the company's growth strategies, pipeline developments, and market opportunities.

Jefferies Global Healthcare Conference 3 June 5, 2025 Forward-looking Statements and Other Important Information This presentation contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding Karyopharm's beliefs about the market opportunity and annual peak revenue opportunities for selinexor; expectations with respect to commercialization efforts; the ability of selinexor to treat patients with multip ...

Summary of Karyopharm Therapeutics (KPTI) Conference Call Company Overview - **Company**: Karyopharm Therapeutics (KPTI) - **Key Products**: Selinexor (XPOVIO) - **Focus Areas**: Oncology, specifically multiple myeloma and myelofibrosis Key Points Commercial Performance and Product Dynamics - **Q1 Demand Growth**: KPTI reported a 5% year-over-year demand growth for XPOVIO in Q1, despite a one-time impact of $5 million from atypical returns related to high-dose selinexor [3][4] - **Real-World Utilization**: The company is focusing on increasing the utilization of selinexor in both community and academic settings, with a particular emphasis on lower doses [4][5] - **Community Treatment**: Selinexor is primarily used in the community setting for multiple myeloma patients, positioned in the second to fourth line of treatment [5][6] Growth Drivers and Future Outlook - **T Cell Engaging Therapies**: KPTI is generating data to support the use of selinexor in conjunction with T cell engaging therapies, which are becoming more prevalent in earlier treatment lines [9][10] - **Myelofibrosis Opportunity**: The ongoing SENTRI trial is evaluating selinexor in combination with ruxolitinib, with promising early data showing a 79% SVR 35 rate at week 24 compared to 30-35% for ruxolitinib alone [12][13][15] - **Durability of Response**: The company reported a 100% durability of response for patients achieving SVR 35 or TSS 50, indicating sustained benefits from treatment [17] Clinical Trials and Data - **Phase III Trials**: KPTI is focused on executing its Phase III trials for both myelofibrosis and endometrial cancer, with the latter leveraging a biomarker (p53 wild type) for patient selection [45][46] - **Endpoint Changes**: The transition from TSS 50 to absolute TSS is seen as a more sensitive measure for symptom improvement, gaining positive feedback from investigators and regulators [28][29] Safety and Tolerability - **Antiemetic Use**: KPTI has incorporated dual antiemetics in its Phase III trials to mitigate nausea and vomiting, achieving over 85% compliance and lower rates of these side effects [36][38] - **Safety Profile**: The safety profile of selinexor is evolving positively, with improvements noted in gastrointestinal side effects [17][38] Commercial Strategy - **Market Positioning**: KPTI aims to target all frontline myelofibrosis patients, leveraging existing commercial infrastructure to facilitate rapid uptake among physicians [41][42] - **Unmet Need**: Research indicates a significant unmet need in the myelofibrosis market, with 75% of physicians willing to adopt therapies that address key disease hallmarks [42] Financial Discipline - **Operational Focus**: KPTI is maintaining a disciplined approach to operational expenditures, concentrating resources on Phase III readouts and shutting down non-essential programs [48][49] Additional Insights - **Endometrial Cancer Landscape**: The company anticipates that selinexor will address a sizable unmet need in patients with p53 wild type tumors, with enrollment for the Phase III trial progressing well [46][47] - **Future Readouts**: KPTI is positioned for significant upcoming data readouts that could transform treatment paradigms in both myelofibrosis and endometrial cancer [49]

Core Insights - Karyopharm Therapeutics Inc. announced that its abstract on selinexor monotherapy for myelofibrosis has been selected for presentation at the 2025 European Hematology Association Annual Meeting [1][2] - The data from the Phase 2 XPORT-MF-035 trial indicates that selinexor shows clinical activity in heavily pretreated myelofibrosis patients, demonstrating spleen volume reduction, hemoglobin stabilization, and symptom improvement [2][4] Summary by Sections Company Overview - Karyopharm Therapeutics is a commercial-stage pharmaceutical company focused on developing novel cancer therapies, particularly through its lead compound, XPOVIO (selinexor), which is a first-in-class oral exportin 1 (XPO1) inhibitor [4][11] - The company has received regulatory approvals for XPOVIO in multiple oncology indications in the U.S. and various international markets, including Europe and China [5][11] Clinical Trial Insights - The XPORT-MF-035 trial involved 24 patients, randomized 1:1 to receive either selinexor monotherapy or physician's choice treatment, with selinexor administered at 80 mg weekly for the first two cycles, then reduced to 60 mg [4] - Key findings from the trial include: - 67% of selinexor-treated patients achieved a spleen volume reduction of 25% or more compared to 38% in the physician's choice group [4] - 33% of selinexor patients achieved a spleen volume reduction of 35% or more versus 13% in the physician's choice group [4] - Patients on selinexor had higher mean hemoglobin levels and lower rates of red blood cell transfusions compared to those on physician's choice [4] Safety and Adverse Events - The most common treatment-emergent adverse events (TEAEs) in the selinexor arm included decreased weight (50%), asthenia (42%), and nausea (33%) [4] - Serious adverse reactions were reported in 52% of patients in the BOSTON trial, with a treatment discontinuation rate of 19% due to adverse reactions [9]

– New Randomized Phase 2 Monotherapy Data from XPORT-MF-035 Trial in a Hard-to-Treat Patient Population Further Strengthens Conviction in Selinexor's Potential in Combination with Ruxolitinib in JAKi-Naïve Myelofibrosis in Ongoing Phase 3 SENTRY Trial –– Phase 3 SENTRY Trial Passed Planned Futility Analysis; Trial is Approximately 80% Enrolled with Target Enrollment Expected in June/July 2025 –– Demand for XPOVIO® (selinexor) Increased 5% in the First Quarter of 2025 Compared to the First Quarter of 2024; T ...