Jaguar Health (JAGX) Q1 2025 Earnings Call May 15, 2025 04:15 PM ET Company Participants Lisa Conte - Founder, CEO, President & DirectorCarol Lizak - Chief Financial Officer Operator Greetings, and welcome to Jaguar Health's May fifteen, twenty twenty five Investor Webcast. Before I turn the call over to management, I'd like to remind you that management may look forward looking statements relating to such matters as continued growth prospects for the company, uncertainties regarding market acceptance of pr ...

Financial Data and Key Metrics Changes - The total net revenue for the company's prescription products was approximately $2.2 million in Q1 2025, a decrease of about 6% compared to $2.4 million in Q1 2024 and a 37% decrease from $3.5 million in Q4 2024 [25] - Loss from operations increased by $1.2 million from $8.2 million in Q1 2024 to $9.4 million in Q1 2025 [26] - Net loss attributable to common shareholders increased by approximately $1.2 million from $9.2 million in Q1 2024 to $10.4 million in Q1 2025 [26] Business Line Data and Key Metrics Changes - Mytesi prescription volume increased by approximately 1.8% in Q1 2025 compared to Q1 2024 but decreased by approximately 13.5% compared to Q4 2024 [26] - Dispensed prescriptions for Mytesi and Profelymer increased by approximately 2% in Q1 2025 compared to Q1 2024, indicating increased demand for treatments [5] Market Data and Key Metrics Changes - Short bowel syndrome affects approximately 10,000 to 20,000 people in Europe and a similar number in the United States, qualifying for orphan designation [19] - MVID is an ultra-rare condition with an estimated prevalence of just a couple hundred patients globally [19] Company Strategy and Development Direction - The company is focusing on the convergence of key catalysts that are expected to be transformational for stakeholders, including paradigm-shifting medicines and mechanisms of action [5] - There are ongoing proof of concept trials for crofelemer in both pediatric and adult patients with rare diseases, with results expected throughout 2025 and into 2026 [21] - The company is exploring expedited regulatory approval pathways for its products, including the FDA's breakthrough therapy program [19] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the multiple expected near-term catalysts throughout 2025 and early 2026, viewing them as important and potentially transformative [27] - The management highlighted the significance of the initial proof of concept results for crofelemer, which could modify disease progression for patients with intestinal failure [12] Other Important Information - The company is also pursuing business development opportunities related to its product CANALIVIA CA1, which is conditionally approved for chemotherapy-induced diarrhea in dogs [28] - The management emphasized the importance of addressing supportive care needs in cancer treatment, as diarrhea can impact treatment outcomes [24] Q&A Session Summary Question: What are the expected catalysts for the company in the near term? - Management highlighted multiple expected catalysts throughout 2025 and early 2026 that are viewed as important for stakeholders [27] Question: How does the company plan to address the regulatory pathways for its products? - The company is exploring expedited regulatory approval pathways, including the FDA's breakthrough therapy program and EMA's PRIME program [19]