Registration No. As filed with the U.S. Securities and Exchange Commission on October 20, 2023 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Scilex Holding Company (Exact name of Registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2836 92-1062542 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identification Number) Scilex Holding Co ...

As filed with the U.S. Securities and Exchange Commission on July 12, 2023 Registration No. 333-271401 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 5 to Form S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Scilex Holding Company (Exact name of Registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2836 92-1062542 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identificatio ...