Core Points - NextCure, Inc. has successfully closed a private placement in public equity (PIPE) with total gross proceeds of approximately $21.5 million [1][8] - The PIPE was led by Ikarian Capital, Squadron Capital Management, Affinity Healthcare Fund, LP, and Exome Asset Management, with participation from other healthcare-focused funds [1][8] - NextCure sold 708,428 shares of common stock at a market price of $8.52 per share and pre-funded warrants to purchase up to 1,815,049 shares at a price of $8.519 per warrant [2] - The net proceeds from the offering will be used for general working capital needs, extending the company's cash runway into the first half of 2027, beyond the planned first half of 2026 [3][8] - H.C. Wainwright & Co. acted as the exclusive placement agent for the offering [3] Company Overview - NextCure is a clinical-stage biopharmaceutical company focused on developing innovative therapies for cancer patients who do not respond to or have disease progression on current therapies [6] - The company specializes in targeted therapies, including antibody-drug conjugates, leveraging its strengths in understanding biological pathways and biomarkers [6]

Core Points - NextCure, Inc. has entered into definitive agreements for a private placement of 2,523,477 shares of common stock at a price of $8.52 per share, expected to close on or about November 13, 2025 [1][3] - The gross proceeds from the offering are anticipated to be approximately $21.5 million, which will extend the company's cash runway into the first half of 2027 [3] - The net proceeds will be used for general working capital needs and to support proof of concept data readouts for two antibody drug conjugate programs, SIM0505 and LNCB74 [3][6] Company Overview - NextCure is a clinical-stage biopharmaceutical company focused on developing innovative therapies for cancer patients who do not respond to existing treatments [6] - The company specializes in targeted therapies, including antibody-drug conjugates, leveraging its expertise in biological pathways and biomarkers [6]

Core Insights - NextCure, Inc. is advancing its antibody-drug conjugate (ADC) programs, particularly SIM0505 and LNCB74, with significant progress in clinical trials and FDA approvals [2][3][4]. Business Highlights and Near-Term Milestones - The company has initiated U.S. enrollment in the Phase 1 trial for SIM0505, a CDH6-targeting ADC, at a mid-tier dose range where multiple clinical responses were previously observed in China [2][3]. - FDA clearance was received for a protocol amendment for LNCB74, allowing for higher dose escalation cohorts [2][4]. - Proof of concept data readouts for both SIM0505 and LNCB74 are expected in the first half of 2026 [2][4]. Financial Results for Quarter Ended September 30, 2025 - Cash, cash equivalents, and marketable securities decreased to $29.1 million from $68.6 million as of December 31, 2024, primarily due to operational funding and a $12.0 million upfront license fee to Simcere Zaiming [5][10]. - Research and development expenses were $6.1 million, down from $8.8 million in the same quarter of 2024, attributed to lower costs from deprioritized programs and reduced personnel-related costs [5][10]. - General and administrative expenses decreased to $2.8 million from $3.7 million year-over-year, mainly due to lower personnel costs [5][10]. - The net loss for the quarter was $8.6 million, an improvement from a net loss of $11.5 million in the same quarter of 2024 [5][10]. Selected Financial Information - Total assets as of September 30, 2025, were $39.6 million, down from $80.9 million as of December 31, 2024 [11]. - Total stockholders' equity decreased to $23.6 million from $65.5 million [11].