Veracyte (NasdaqGM:VCYT) Q4 2025 Earnings call February 25, 2026 04:30 PM ET Company ParticipantsJohn Leite - Global Chief Commercial OfficerKyle Mikson - Managing DirectorMarc Stapley - CEOPhillip Febbo - Chief Scientific Officer and Chief Medical OfficerRebecca Chambers - CFOShayla Gorman - Senior Director of Investor RelationsConference Call ParticipantsAndrew Brackmann - AnalystBill Bonello - Senior Research AnalystDoug Schenkel - Managing Director and Senior Research AnalystKeith Hinton - Senior Analys ...

Veracyte (NasdaqGM:VCYT) Q4 2025 Earnings call February 25, 2026 04:30 PM ET Company ParticipantsJohn Leite - Global Chief Commercial OfficerKyle Mikson - Managing DirectorMarc Stapley - CEOPhillip Febbo - Chief Scientific Officer and Chief Medical OfficerRebecca Chambers - CFOShayla Gorman - Senior Director of Investor RelationsConference Call ParticipantsAndrew Brackmann - AnalystBill Bonello - Senior Research AnalystDoug Schenkel - Managing Director and Senior Research AnalystKeith Hinton - Senior Analys ...

Veracyte (NasdaqGM:VCYT) Q4 2025 Earnings call February 25, 2026 04:30 PM ET Speaker12Please be advised that today's conference is being recorded. I would now like to hand the conference over to your first speaker today, Shayla Gorman, Senior Director, Investor Relations. Please go ahead.Good afternoon, everyone. Thank you for joining us today for a discussion of our fourth quarter and full year 2025 financial results. With me today are Marc Stapley, Veracyte's Chief Executive Officer, and Rebecca Chambers, ...

Veracyte FY Conference Summary Company Overview - **Company**: Veracyte (NasdaqGM:VCYT) - **Industry**: Medtech and Diagnostics Key Financial Highlights - **Q3 Revenue**: Over $131 million, a growth of 14% year-over-year [4] - **Testing Business Growth**: Grew by 17%, with Decipher achieving over 25% growth for 14 consecutive quarters [4] - **Afirma Growth**: Volume increased by 13%, driven by new accounts and deeper penetration into existing accounts [4] - **Adjusted EBITDA**: Reached 30% for the quarter, exceeding expectations, with a forecast to finish the year over 25% [5] Decipher Product Insights - **Market Penetration**: Estimated at 40%, indicating room for growth [7] - **Durability of Growth**: Anticipated demand increase due to the recent launch of the metastatic indication and ongoing clinical trials [8][10] - **Physician Ordering Dynamics**: Changes in how tests are ordered, with a focus on building trust and integrating test ordering into clinical workflows [11][12] NCCN Guidelines Impact - **Guideline Inclusion**: The inclusion of Decipher in NCCN guidelines has provided a tailwind for growth, although isolating the impact from other factors is challenging [14] Digital Pathology and Competitive Landscape - **Digital Pathology Positioning**: Emphasized as complementary to existing tests, with a focus on avoiding confusion among clinicians [16] - **Discordance with Competitors**: Noted a 30% discordance rate between Decipher and a competing test, highlighting Decipher's validation and reliability [18][19] Future Product Developments - **V2 Transcriptome Transition**: Aiming for full transition by the end of the year, expected to enhance efficiency and reduce test failures [29][30] - **Prosigna LDT Launch**: Planned for mid-2026, with a focus on building a commercial team and engaging key opinion leaders [42][43] Market Strategy and Growth Drivers - **Growth Drivers**: Focus on Afirma, Decipher, Prosigna, MRD, and IBD, with a balanced approach to investment and growth [62] - **Market Penetration Goals**: Targeting 80% penetration in the market, currently at 65% [28] Capital Allocation and M&A Strategy - **Cash Position**: Expected to be close to $400 million with no debt, allowing for strategic investments and potential M&A opportunities [70] - **M&A Focus**: Prioritizing investments in core business areas before considering acquisitions [71] Conclusion - Veracyte is positioned for continued growth with strong financial performance, innovative product offerings, and a strategic focus on market penetration and operational efficiency. The company is actively engaging in expanding its product portfolio while maintaining a disciplined approach to capital allocation and investment in growth drivers.