Core Viewpoint - The article discusses a significant advancement in the field of biomanufacturing, focusing on the development of a technology called FLASH (flow-led assembly for spiral hierarchical structure) that enables the scalable fabrication of aligned myocardial tissues with a native-like helical architecture for heart repair [2][5]. Group 1: Research Background - The natural helical arrangement of myocardial fibers is crucial for efficient heart pumping, yet replicating this structure on a large scale remains a major challenge in biomanufacturing [2]. - The research published by Tsinghua University highlights the importance of mimicking the anisotropic structure of human heart tissue to enhance the functionality of engineered myocardium and improve cardiac tissue models' pumping performance [4]. Group 2: FLASH Technology - FLASH technology combines biomimetic structural design with scalable manufacturing processes, paving the way for organ-level cardiac models suitable for disease modeling, drug testing, and regenerative therapy [7]. - This microfluidic platform assembles high cell density microfibers, with a core made of collagen/matrix gel containing cardiomyocytes and a sheath layer of alginate containing endothelial cells [5]. - Compared to traditional bioprinting techniques, FLASH achieves over 90% alignment rate of cardiomyocytes, adjustable mechanical anisotropy, and triples the spatial resolution/manufacturing time (RTM) [5]. Group 3: Experimental Results - The spiral ventricular model constructed using FLASH demonstrates coordinated ventricular scale contraction [5]. - In a rat myocardial infarction model, cardiac patches made using FLASH significantly improved heart function and reduced fibrosis [5].