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Xilio Therapeutics Announces Pipeline and Business Updates and Second Quarter 2025 Financial Results
Globenewswire· 2025-08-14 11:30
Core Insights - Xilio Therapeutics announced updated Phase 2 data for vilastobart, showing deep and durable responses with a differentiated safety profile for anti-CTLA-4 combination therapy [1][5] - The company is on track to nominate its first development candidates for masked T cell engager programs in the second half of 2025 [1][12] - As of June 30, 2025, Xilio reported $121.6 million in cash and cash equivalents, providing a cash runway through the end of the third quarter of 2026 [1][13] Pipeline and Business Updates - Vilastobart is a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody currently evaluated in combination with atezolizumab for advanced solid tumors and metastatic microsatellite stable colorectal cancer [3][14] - XTX301, a tumor-activated IL-12, is designed to stimulate anti-tumor immunity and is being evaluated as a monotherapy in a Phase 1 clinical trial [4][15] - Xilio's masked T cell engager programs include bispecific and tri-specific molecules designed to enhance T cell activation and are advancing through IND-enabling studies [7][9] Financial Results - Collaboration and license revenue for the quarter ended June 30, 2025, was $8.1 million, up from $2.4 million in the same quarter of 2024 [17] - Research and development expenses increased to $15.3 million in Q2 2025 from $11.2 million in Q2 2024, driven by clinical development activities [17] - The net loss for the quarter ended June 30, 2025, was $15.8 million, compared to a net loss of $13.9 million for the same period in 2024 [17][23]
Xilio Therapeutics (XLO) Earnings Call Presentation
2025-07-03 06:50
Pipeline and Programs - Vilastobart (tumor-activated anti-CTLA-4) reported a preliminary Objective Response Rate (ORR) of 26% in Phase 2 for heavily pre-treated patients with microsatellite stable colorectal cancer (MSS CRC) without liver metastases[35, 41] - XTX301 (tumor-activated IL-12) is advancing in partnership with Gilead, with a potential $75 million option fee at Phase 1/2 data package[67, 69] - XTX501 (tumor-activated PD-1/IL-2 bispecific) IND submission is anticipated in mid-2026[74] - The company plans to nominate development candidates for PSMA, CLDN182, and STEAP1 masked T cell engager programs in Q3 2025, Q4 2025, and 1H 2026, respectively[24, 101] Financials and Partnerships - The company had $89.1 million in cash and cash equivalents as of March 31, 2025[120] - The company received approximately $47.2 million in estimated net proceeds from equity financing in June 2025[120] - The company anticipates a cash runway through the end of Q3 2026[21, 120] - The company is eligible to receive up to $100 million in additional gross proceeds from equity financing by 2H 2026[21, 120] - The company has a collaboration, license, and option agreement with AbbVie for tumor-activated immunotherapies, including masked T cell engagers, with up to ~$2.1 billion in total contingent payments[20, 113] Technology and Approach - The company's platform exploits dysregulated matrix metalloprotease (MMP) activity in tumors to activate molecules[12] - The company's masked T cell engagers are designed to optimize the therapeutic index by maximizing tumor exposure and minimizing peripheral activity and off-tumor cytotoxicity[98]