KOL webinar to take place on July 22, 2025, at 1:00 p.m. ETSAN DIEGO and CALGARY, AB, July 10, 2025 /PRNewswire/ -- Oncolytics Biotech® Inc. (NASDAQ: ONCY) (TSX: ONC), a leading clinical-stage company specializing in immunotherapy for oncology, announced that it will host a key opinion leader (KOL) webinar to discuss pelareorep in metastatic pancreatic ductal adenocarcinoma (mPDAC) and other gastrointestinal cancers. The webinar will take place on Tuesday, July 22, 2025, at 1:00 p.m. ET.The webinar will fea ...

Comparison with multiple landmark first-line metastatic pancreatic ductal adenocarcinoma studies substantiates strong two-year survival benefit of 21.9% vs. 9.2% historical benchmark Consistent survival benefit compared to standard-of-care chemotherapy in randomized studies in the large HR+/HER2- metastatic breast cancer indication Data from over 1,100 patients across tumor types reveals a favorable, well-understood safety profile SAN DIEGO and CALGARY, AB, July 8, 2025 /PRNewswire/ -- Oncolytics Biotech® I ...

Core Insights - Oncolytics Biotech Inc. has appointed Andrew Aromando as Chief Business Officer to lead global business development and corporate strategies [1][2][3] - Aromando's previous experience includes a significant role in the $2 billion acquisition of Ambrx Biopharma by Johnson & Johnson, highlighting his expertise in navigating complex transactions [2][3] - The company aims to optimize the value of its clinical data for pelareorep, an immunotherapeutic agent, targeting multiple cancer types including pancreatic, breast, and anal cancers [2][5] Company Overview - Oncolytics Biotech Inc. is a clinical-stage biotechnology company focused on developing pelareorep, which has shown promising results in clinical studies for metastatic breast cancer and pancreatic cancer [5][6] - Pelareorep works by inducing anti-cancer immune responses and transforming "cold" tumors into "hot" tumors, enhancing treatment efficacy [5][6] - The company is advancing towards registrational studies for pelareorep in metastatic breast cancer and pancreatic cancer, both of which have received Fast Track designation from the FDA [6] Executive Compensation - As part of Aromando's appointment, he received an initial stock option grant for 750,000 shares at an exercise price of CAD$0.93, vesting over three years [4] - Additionally, he was granted 500,000 restricted stock units that will vest upon the company entering into a definitive agreement for certain transactions [4]

Company Overview - Oncolytics Biotech Inc. is a clinical-stage biotechnology company focused on developing pelareorep, an intravenously delivered immunotherapeutic agent with promising results in treating various cancers [6][7] - Pelareorep has received FDA Fast Track designation for metastatic pancreatic ductal adenocarcinoma (mPDAC) and HR+/HER2- metastatic breast cancer (mBC) [3][6] Leadership Appointment - Jared Kelly has been appointed as the Chief Executive Officer and a member of the Board of Directors, bringing extensive experience in biotech and corporate strategy [1][2] - Kelly's previous role included orchestrating the $2 billion sale of Ambrx Biopharma to Johnson & Johnson, showcasing his expertise in transformative deals [2] Clinical Data and Development - Pelareorep has shown a greater than 60% objective response rate in mPDAC patients, significantly outperforming historical control trials [3] - In mBC, pelareorep demonstrated meaningful survival benefits in two randomized Phase 2 studies involving over 100 patients [4] - The agent has a favorable safety profile based on data from over 1,100 patients across multiple tumor types [4] Strategic Focus - The company aims to advance pelareorep through a renewed clinical development plan, targeting partnerships to enhance its market potential [3][4] - Oncolytics is conducting combination clinical trials with pelareorep in solid malignancies, moving towards registrational studies in mBC and pancreatic cancer [7] Incentives for Leadership - As part of his appointment, Kelly received stock options for 2,850,000 shares and performance-based options for 1,900,000 shares, aligning his incentives with shareholder value creation [5]

Pelareorep initiates a pro-inflammatory tumor microenvironment (TME) and induces innate and adaptive immune responsesNew analyses confirm that pelareorep primes the TME to allow circulating tumor-infiltrating lymphocytes (TILs) in the blood to attack tumorsPre-existing TIL clones in plasma may correlate positively with tumor shrinkage in pancreatic cancerSAN DIEGO and CALGARY, AB, May 23, 2025 /PRNewswire/ -- Oncolytics Biotech® Inc. (NASDAQ: ONCY) (TSX: ONC), a leading clinical-stage company specializing i ...

Oncolytics Biotech (ONCY) Q1 2025 Earnings Call May 14, 2025 04:30 PM ET Company Participants Jon Patton - Director, IR & CommunicationWayne Pisano - Interim CEO & Chairman of the BoardThomas Heineman - Chief Medical OfficerChristophe Degois - VP, Business DevelopmentKirk Look - Chief Financial OfficerPatrick Trucchio - Managing Director Conference Call Participants Michael Freeman - Equity Research Analyst - Healthcare Operator Good afternoon, and welcome to OnClinic's Biotech's First Quarter Conference Ca ...

Oncolytics Biotech (ONCY) Q1 2025 Earnings Call May 14, 2025 04:30 PM ET Speaker0 Good afternoon, and welcome to OnClinic's Biotech's First Quarter Conference Call. All participants are now in listen only mode. There will be a question and answer session at the end of this call. Please be advised that this call is being recorded at the company's request. I would now like to turn the call over to John Pattern, Director of Investor Relations and Communication. Please go ahead. Speaker1 Thank you, operator. To ...

American Society of Clinical Oncology (ASCO) GI Symposium data underscores pelareorep's clinical benefit in anal and pancreatic cancersPelareorep featured in Key Opinion Leader event on oncolytic immunotherapies in breast and pancreatic cancersPoster on pelareorep's stimulation of adaptive and innate immunity to be shared at ASCO Annual MeetingConference call and webcast today at 4:30 p.m. ET to discuss Q1 results and clinical outlookSAN DIEGO, Calif. and CALGARY, AB, May 14, 2025 /PRNewswire/ -- Oncolytics ...

Oncolytics Biotech Inc. (NASDAQ:ONCY) Q4 2024 Results Conference Call March 7, 2025 8:30 AM ET Company Participants Jon Patton - Director of Investor Relations and Communications Wayne Pisano - Chairman of Oncotic's Board of Directors and Interim CEO Tom Heineman - Chief Medical Officer Kirk Look - Chief Financial Officer Christophe Degois - Vice President of Business Development Conference Call Participants Michael Freeman - Raymond James Luis Santos - H.C. Wainwright Operator Good morning, and welcome to ...

Core Insights - Oncolytics Biotech Inc. reported strong efficacy signals for its lead candidate, pelareorep, in treating HR+/HER2- metastatic breast cancer, pancreatic cancer, and anal cancer, indicating potential for redefining treatment landscapes in these high-need areas [1][2][16] - The company has a cash position of $15.9 million, providing a runway through critical milestones into the third quarter of 2025 [1][11] - Management is focused on advancing pelareorep towards registration-enabling studies, with significant data supporting its efficacy in multiple cancer types [2][4][6] Clinical Development - The BRACELET-1 trial demonstrated robust improvements in progression-free survival (PFS) and overall survival (OS) for patients receiving pelareorep combined with paclitaxel compared to paclitaxel alone [4][6] - The GOBLET study showed a 33% objective response rate in anal cancer patients treated with pelareorep and atezolizumab, including a complete response lasting over 15 months [5][15] - Ongoing combination studies in pancreatic cancer have cleared safety milestones, allowing for continued enrollment in the GOBLET study [5][15] Financial Performance - For Q4 2024, the company reported a net loss of $8.0 million, compared to a net loss of $3.9 million in Q4 2023, with a basic and diluted loss per share of $0.10 [11][14] - Research and development expenses for Q4 2024 were $4.6 million, slightly down from $4.7 million in Q4 2023, primarily due to lower personnel-related expenses [11][14] - The total assets as of December 31, 2024, were $20.2 million, down from $38.8 million in 2023, reflecting the company's ongoing investment in clinical trials [12][14] Anticipated Milestones - In H1 2025, the company plans to finalize the protocol for an adaptive registration-enabling trial for pelareorep in first-line pancreatic ductal adenocarcinoma and submit it to the FDA [11][19] - In H2 2025, the first patient is expected to be enrolled in the registration-enabling study for pelareorep and paclitaxel in advanced or metastatic HR+/HER2- breast cancer [11][19] - Initial efficacy results from Cohort 5 of the GOBLET study are anticipated in H2 2025, investigating pelareorep combined with modified FOLFIRINOX in newly diagnosed metastatic pancreatic cancer [11][19]