Core Insights - ProKidney Corp. is a leading late clinical-stage cellular therapeutics company focused on chronic kidney disease (CKD) [1][2] - The company will participate in two upcoming healthcare conferences in November 2025, including the Guggenheim Healthcare Innovation Conference and the Jefferies Global Healthcare Conference [1] Company Overview - ProKidney was founded in 2015 after a decade of research and is a pioneer in the treatment of CKD through innovations in cellular therapy [2] - The lead product candidate, rilparencel (REACT), is a first-in-class, patented, proprietary autologous cellular therapy with regenerative medicine advanced therapy designation [2] - Rilparencel is currently being evaluated in the ongoing Phase 3 REGEN-006 (PROACT 1) study for its potential to preserve kidney function in patients with advanced CKD and type 2 diabetes [2]

Core Insights - ProKidney Corp. will present two posters at the American Society of Nephrology's Kidney Week from November 6-9, 2025, including a late-breaking poster on the Phase 2 REGEN-007 study results [1][2] Group 1: Presentation Details - The late-breaking poster is titled "Renal Autologous Cell Therapy in Diabetes and CKD (Phase 2 REGEN-007 Study Results)" and will be presented on November 6, 2025, from 10:00 AM to 12:00 PM CST [2] - The other poster presentation is focused on "Cell-Specific Inflammatory Profile Characterization of the Cell Therapy Candidate Rilparencel," also scheduled for November 6, 2025, during the same time frame [2] Group 2: Company Background - ProKidney Corp. specializes in cellular therapeutics for chronic kidney disease (CKD) and was founded in 2015 after a decade of research [3] - The company's lead product candidate, rilparencel (REACT), is a patented autologous cellular therapy currently in the Phase 3 REGEN-006 (PROACT 1) study, aimed at preserving kidney function in patients with advanced CKD and type 2 diabetes [3]

Core Insights - ProKidney Corp is highlighted as a promising investment opportunity in the healthcare penny stock sector, particularly due to its focus on the cell therapy Reparencel [1] - The company is currently in Phase 3 of the Proactive One study, with top-line results expected by the second quarter of 2027 [2] - ProKidney is targeting high-risk patients with chronic kidney disease, specifically those with a GFR of 30 or less, and has completed 50% of enrollment for the study [2] Financial Position - As of June, ProKidney holds $295 million in cash, which is deemed sufficient to support the ongoing clinical trial [2] - The company is also enhancing its manufacturing capacity in North Carolina to prepare for anticipated strong demand for its therapy [2] Product Development - ProKidney is developing a first-in-class cell therapy, rilparencel (REACT), aimed at treating Chronic Kidney Disease (CKD) [2] - The therapy utilizes a patient's own kidney cells to potentially preserve kidney function and delay the need for dialysis [2]

Core Insights - ProKidney Corp. is a leading late clinical-stage cellular therapeutics company focused on chronic kidney disease (CKD) [1][3] - The company will participate in two healthcare conferences in September 2025, showcasing its commitment to engaging with investors and the healthcare community [1][2] Conference Participation - ProKidney will attend the Citi Biopharma Back to School Conference in Boston on September 3, 2025, at 10:30 am ET, in a fireside chat format [1] - The company will also participate in the Morgan Stanley Global Healthcare Conference in New York on September 8, 2025, at 7:00 am ET, also in a fireside chat format [2] Product Development - ProKidney's lead product candidate, rilparencel (REACT), is a first-in-class, patented autologous cellular therapy aimed at preserving kidney function in patients with advanced CKD and type 2 diabetes [3] - The product is currently being evaluated in the ongoing Phase 3 REGEN-006 (PROACT 1) study, highlighting the company's focus on innovative treatments for CKD [3]

Core Viewpoint - ProKidney Corp. is actively engaging with investors through participation in the H.C. Wainwright 4 Annual Kidney Virtual Conference, highlighting its focus on chronic kidney disease and its innovative cellular therapy approach [1]. Company Overview - ProKidney Corp. is a pioneer in chronic kidney disease treatment through cellular therapy innovations, founded in 2015 after a decade of research [2]. - The company's lead product candidate, rilparencel (REACT), is a first-in-class autologous cellular therapy currently in Phase 2 and Phase 3 studies aimed at preserving kidney function in diabetic patients at high risk of kidney failure [2]. - Rilparencel has received Regenerative Medicine Advanced Therapy (RMAT) designation from the FDA, indicating its potential significance in the treatment landscape [2].

Core Points - ProKidney Corp. has completed the domestication process, changing its jurisdiction of incorporation from the Cayman Islands to Delaware, effective July 1, 2025 [1] - Shareholders approved the domestication at the Annual General Meeting on May 29, 2025, with Class A and Class B ordinary shares converting to common stock [1] - ProKidney's common stock will begin trading on Nasdaq under the unchanged symbol "PROK" starting July 2, 2025 [1] - The company does not expect any impact on day-to-day business operations due to the domestication [1] Company Overview - ProKidney is focused on chronic kidney disease (CKD) and is a pioneer in cellular therapy, founded in 2015 after a decade of research [3] - The lead product candidate, rilparencel (REACT), is a first-in-class autologous cellular therapy in Phase 2 and Phase 3 studies aimed at preserving kidney function in diabetic patients at high risk of kidney failure [3] - Rilparencel has received Regenerative Medicine Advanced Therapy (RMAT) designation from the FDA [3]

Core Insights - ProKidney Corp. reported financial results for Q1 2025, highlighting its focus on chronic kidney disease (CKD) and upcoming milestones in clinical trials [1][2] Financial Highlights - As of March 31, 2025, ProKidney had cash, cash equivalents, and marketable securities totaling $328.5 million, down from $358.3 million at the end of 2024, which is expected to fund operations into mid-2027 [4][8] - Research and development expenses were $27.3 million for Q1 2025, slightly up from $27.2 million in Q1 2024, with increases in cash compensation and facility costs offset by a decrease in clinical trial costs [5] - General and administrative expenses rose to $14.4 million in Q1 2025 from $12.8 million in Q1 2024, primarily due to higher cash compensation and professional fees [6] - The net loss before noncontrolling interest was $38.0 million for Q1 2025, compared to $35.3 million for the same period in 2024 [7] Clinical Development - The company is approaching key milestones, including the release of full Group 1 data from the Phase 2 REGEN-007 study and a regulatory update on the accelerated approval pathway for rilparencel following a Type B meeting with the FDA [2][8] - Full data from Group 1 of the Phase 2 REGEN-007 study is expected in Q2 2025, involving approximately 20 patients with an average follow-up of 18 months [9] - The Phase 3 REGEN-006 (PROACT 1) clinical trial is ongoing, focusing on patients with type 2 diabetes and advanced CKD, with a total planned enrollment of approximately 685 subjects [10] Company Overview - ProKidney Corp. specializes in cellular therapeutics for chronic kidney disease, with its lead product candidate, rilparencel, being evaluated in late-stage clinical trials [12]