Financial Data and Key Metrics Changes - Total revenue for Q4 2022 was 86.6million,representingayear−over−yeargrowthof15335.6 million, which represents a 17% growth on a reported basis and 20% growth on a constant currency basis [12][61] - Adjusted EBITDA margin was 36.8% in Q4 2022 and 35.8% for the full year 2022 [57] - Reported adjusted net income for Q4 2022 was 25.2millioncomparedto9.8 million for Q4 2021 [57] - Bookings for the trailing 12 months ended December 31, 2022, were 408.9million,up2039.5 million in Q4 2022, increasing 22% from the prior year period [8] - Services revenue was 57.5millioninQ42022,whichincreased15370 million to 385million,representing10236.6 million in cash and cash equivalents and $297.5 million in outstanding borrowings on its term loan [57] Q&A Session Summary Question: Can you provide insights on the size, growth, and margin profile of M&A? - Management indicated that the outlook for the year does not embed any M&A contributions beyond completed deals, but it could be a source of upside [1] Question: What is the performance of the software side and sales environment? - The software side showed better-than-expected performance, with strong traction in the marketplace and execution [5] Question: How is the regulatory business performing? - The regulatory business was down 3% year-over-year, but there are signs of recovery and optimism for growth in 2023 [79] Question: What are the pricing expectations for this year? - Pricing expectations are consistent with historical trends, in the range of 3% to 5% [21] Question: How is the company addressing opportunities in China and other geographies? - The company sees China as an opportunity, currently representing 2% to 3% of revenues, and is making investments to grow its presence there [23] Question: What is the status of the partnership with Memorial Sloan Kettering? - The partnership is still a work in progress, with valuable data being utilized for biosimulation, but significant results are expected to take two to three years [40]