Transaction Overview - Boston Scientific announced a definitive agreement to acquire Penumbra, valuing the company at $374 per share[10] - The transaction consideration reflects a total equity value of $15 billion, funded by approximately $11 billion in cash and approximately $4 billion in Boston Scientific stock, resulting in a 73% cash, 27% stock mix[29] - The equity issuance is expected to be approximately 41 million shares, fixed at the time of signing based on Boston Scientific's 10-day VWAP ending January 13, 2026[29] - The transaction is expected to close in 2026, subject to Penumbra shareholder approval and customary closing conditions[28, 29] Penumbra Financials and Market Opportunity - Penumbra's Q4 2025 reported revenue growth is +21.4-22.0% compared to 2024[13] - Penumbra's FY25 reported revenue growth is +17.3-17.5% compared to 2024[13] - Penumbra's FY25E gross margin is 67.9-68.1% and operating margin is 13.3-13.6%[13] - Penumbra operates in large, underserved spaces including mechanical thrombectomy, embolization, and neurovascular segments[10] - The total annual U S opportunity includes 315,000+ peripheral patients and 175,000 MMAe patients[16] Strategic Rationale - The acquisition provides Boston Scientific with entry into new key segments with a WAMGR accretive to Boston Scientific[10] - The combination is expected to deliver meaningful revenue contribution and cost efficiencies, supporting long-range planning goals[10] - Penumbra has a WAMGR of approximately 11% in high-growth adjacent areas[18]

Financial Performance - BlackRock's Assets Under Management (AUM) reached $14.0 trillion as of December 31, 2025[2] - Q4 2025 Base Fees and Securities Lending Revenue totaled $5.3 billion[2] - Q4 2025 Operating Income, as adjusted, was $2.848 billion[8] - Q4 2025 EPS, as adjusted, reached $13.16[9] Asset Flows and Growth - Total BlackRock experienced net inflows of $82 billion in Q4 2025[5] - ETFs Long-term organic asset growth rate was 12% in Q4 2025[5] - Long-term Cash organic asset growth rate was 3% in Q4 2025[5] Revenue Analysis - Base fees accounted for 73% of quarterly revenue[22] - Base fees increased by 20% year-over-year and 5% sequentially in Q4 2025[22] - Performance fees increased by 67% year-over-year and 46% sequentially in Q4 2025[22] Expense Analysis - Employee compensation & benefits increased by 28% year-over-year and 9% sequentially in Q4 2025[34]

2026 CORPORATE PRESENTATION January 2026 PHARMACEUTICALS INC. Various statements in this presentation, including, but not limited to, the guidance provided under "2025 Financial Guidance" and statements regarding Vanda's commercial products, plans, priorities and opportunities, as well as statements about Vanda's strategic focus and its products in development and the related clinical development and regulatory timelines and commercial and therapeutic potential for such products, are "forward-looking statem ...

Disclaimer Accelerating Energy Transition Through Battery Materials Discovery and Health Management January 2026 Although all information and opinions expressed in this Presentation, including market data and other statistical information, were obtained from sources believed to be reliable and are included in good faith, SES has not independently verified the information and makes no representation or warranty, express or implied, as to its accuracy or completeness. Some data is also based on the good faith ...

Evorpacept Program - ALX Oncology's Evorpacept is a leading CD47 program with a unique design and inactive Fc region, showing activity in five combinations and targeting a CD47 biomarker[8] - In HER2+ Gastric Cancer, the Overall Response Rate (ORR) increased from 26% with Trastuzumab + Ramucirumab + Paclitaxel to 65% with Evorpacept + Trastuzumab + Ramucirumab + Paclitaxel in the ASPEN-06 subset, a randomized Phase 2 trial[31] - In HER2+ Breast Cancer, the ORR was 56% with Evorpacept + Zanidatamab compared to a benchmark of 22% with Margenza® + Chemo[32] - In indolent NHL, the complete response rate improved from a Rituximab benchmark of 18% to 54% with Evorpacept + Rituximab[35] - The addition of Evorpacept reduced the risk of disease progression or death by 61% for patients with retained HER2+ disease and high CD47 expression (Hazard Ratio = 0.39)[46] - The addition of Evorpacept led to improved overall survival for patients with retained HER2+ and high CD47 expression (Hazard Ratio = 0.63)[49] - Approximately 20,000 addressable patients are CD47-high in 2L+ HER2+ Breast Cancer, representing a $2-4 billion market opportunity[73] ALX2004 Program - ALX2004 is a highly differentiated EGFR ADC in Phase 1 dose escalation, targeting EGFR-expressing tumors including NSCLC, CRC, HNSCC, and ESCC, with initial safety data anticipated in 1H 2026[8, 99] - Preclinical data supports dose-dependent activity and a differentiated safety profile for ALX2004, with no evidence of payload-related ILD in NHP toxicity studies[8, 82] - ALX Oncology's projected cash runway extends into Q1 2027, driving key milestones for both Evorpacept and ALX2004 programs[10, 105]

Unleash Innovation 2025 Fourth Quarter Earnings Conference January 15, 2026 © 2026 TSMC, Ltd 1 TSMC Property Unleash Innovation Agenda Unleash Innovation • Welcome Jeff Su, IR Director C.C. Wei, Chairman & CEO • Q&A © 2026 TSMC, Ltd 2 TSMC Property • Key Messages Wendell Huang, CFO • 4Q25 Financial Results and 1Q26 Outlook Wendell Huang, CFO Unleash Innovation Safe Harbor Notice © 2026 TSMC, Ltd 3 TSMC Property • TSMC's statements of its current expectations are forward-looking statements subject to signifi ...

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AVITA Medical®, Inc | Cary Vance, Interim CEO J.P. Morgan Healthcare Conference (ASX: AVH, NASDAQ: RCEL) Forward-Looking Statements & Legal Disclaimers This presentation and the accompanying oral commentary may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements are predictions and subject to significant risks and uncertainties that could cause actual results to differ materially from those expressed or implied. Forward-looking stat ...

Investor Presentation January 2026 Safe Harbor Statement This presentation and the related conference call and webcast contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, among others, statements regarding Cytek's expected revenue for the fourth quarter and full year ended December 31, 2025; Cytek's market position and long-term market expansion opportunities; Cytek's business, product and operational goals and strategies; and Cytek's opp ...

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