Leadership Challenges - 40% of new leaders fail within 18 months, indicating a significant challenge in leadership transition and effectiveness [6] - Leaders often mistakenly address strategy problems when the root cause is a leadership issue, highlighting the importance of self-awareness and adaptability [7] - Great leaders often fail by applying a one-size-fits-all approach, emphasizing the need for dynamic leadership that adapts to individual needs and situations [8] Dynamic Leadership Framework - The dynamic leadership framework consists of four approaches: Astronomer (visionary), Coach (relationship-oriented), Captain (sets high standards), and Engineer (hands-on execution) [13][14][22] - The Astronomer inspires with a compelling vision, emphasizing the importance of hope and future orientation in leadership [14][15] - The Coach builds trust through personal connections and feedback, highlighting the significance of one-on-one interactions and active listening [17][18][19] - The Captain sets high standards and ensures accountability, balancing kindness with firmness [20][21] - The Engineer focuses on execution and getting into the details, emphasizing the importance of being on the front lines with the team [22][23] Adaptability and Empathy - Leaders need to adapt their style to meet people where they are, rather than expecting everyone to conform to a single approach [25][26] - Empathy involves seeking to understand others before seeking to be understood, fostering connection and resonance [27][28] - Inconsistency in leadership style, when intentional, can create a deeper respect from team members [29][30] Key Steps to Successful Leadership - Get to know your default leadership style and strengths [32] - Understand what other approaches work well and when to use them [32] - Get to know your people really well [32]

Disaster Recovery Challenges - Current disaster recovery systems disproportionately disadvantage those with fewer economic resources, accelerating displacement and potentially leading to a "land grab" by corporations [6][7][8] - Existing recovery processes often fail to meet fundamental needs, resulting in original residents being displaced from their communities [8] - Tenants and Black homeowners, particularly in West Altadena, face the highest risk of permanent displacement following disasters [9][10][13] Universal Design Approach to Disaster Recovery - Universal design focuses on designing recovery around people instead of property or profit, prioritizing the needs of the most vulnerable [8][15] - A universal design recovery necessitates directing resources and planning towards those most at risk of displacement [15][16] - Short-term strategies include a post-disaster universal basic income program and an insurance gap program to stabilize tenants and homeowners [17][18] - Medium-term strategies involve land banking through community land trusts, policy protections, and rebuilding that prioritizes residents' needs [19][20] - Long-term strategies emphasize community ownership and protections against gentrification and displacement [20][21] Call to Action - The report urges government, philanthropy, and community members to support a universal design approach to disaster recovery through advocacy, funding, and prioritizing the needs of the most vulnerable [21][22][23]

Hi, this is my dog Rossy and I'm a dog trainer, which basically means I spend most of my day handing out snacks and convincing other people's dogs that I'm more interesting than a squirrel. [laughter] My husband and I, along with our two dogs, lost our Altadena home in the Eaton Canyon fire. Today, I'm going to share with you what dog training taught me about rebuilding a home and reclaiming our lives.From a very young age, I was obsessed with animals. I can't think of a birthday I didn't ask for a pony. An ...

[screaming] [applause] What's in your trash? Jam jar, detergent jug, ketchup bottle. As Annie Leonard, sustainability expert, says, "There's no such thing as away. When we throw anything away, it must go somewhere. I became interested in the life cycle of plastic containers over 20 years ago when taking my first job in the natural grocery industry.There I found that I loved learning about the products, stocking shelves, and shopping in the bulk department. I became a certifiable grocery nerd. What I didn't ...

Robotics Industry & Dexterity - Looper Robotics believes robotics will be the biggest industry in human history, with dexterity being the bottleneck [2][3] - The industry is studying and codifying dexterity learned from people using smart gloves to capture hand movements and senses [4] - This data is used to teach robot hands practical skills, transferring human dexterity to robots [5] Applications & Potential - Today, these gloves teach robots to grasp and assemble, potentially reducing workplace injuries and tackling food insecurity [6] - Tomorrow, they could guide robotic surgeons in rural hospitals or disaster zones and restore touch through prosthetic hands [6] - In 10 years, fleets of machines could share dexterity, rebuilding cities, repairing underwater cables, or exploring dangerous environments [7] Labor Market & Automation - The United States has 380,000 unfilled jobs in manufacturing, with a potential shortfall of up to 3 million workers within a decade [7] - Demographics and math are forcing the largest automation wave in modern American history [9] - Robotics can shrink inequality if built with intention, but could also displace millions of workers and concentrate power [9][10] Economic & Geopolitical Implications - Labor is becoming a commodity once more, like "the next oil," with repeatable physical and cognitive work becoming measurable and programmable [11][12] - The nations and firms that control this new commodity will have significant leverage [12] - The US needs to rewire itself to use AI at scale, seeing it as a lubricant to make systems run better, not just perfecting models [15] Policy & Strategy - An actionable idea would be a robot tax index to automation intensity, rechanneling gains into training and safety [14] - The US has no shot at winning the AI race without robotics, as AI's value is in what it touches [14][15] - Robotics is synonymous with the manufacturing of labor and should be scaled to create infrastructure that extracts value from AI [16]

For 5,000 years, humans have been trying to solve one thing. Not cancer, not aging, not heartbreak, the hangover. The history of hangover cures reads like a comedy of errors.Ancient Egypt, dried bird beaks. The Greeks laurel reefs soaked in olive oil. Mongolia pickled sheep eyeballs in tomato juice.Today we call that the bloody Mary. Alcohol isn't just a drink. It's woven into nearly every culture.It marks celebrations and connections and everyday life. But the biggest myth still lives on. This hangover is ...

[applause] How old are you. >> 63. >> 63.So that's your driver's license age, right. What's your real age. Like how old is your body.Do you know. >> 24. >> 24.That's a number. Is it a number that we can trust. Is it a number that you can trust.It's kind of hard to say. You guys heard from my friend Matt earlier, Matt Cberline. He was the aging professor um who's you know very serious about this field and also a skeptical person.So you heard that he ordered the same biological age test three times. He took t ...

I'm going to talk about menopause and I'm going to talk about it in the sense of we already know so much about it or whatever we've heard but a lot of what we haven't heard about it is resilience and so I want to focus on how the brain and our emotions are fashioned by estrogen and we know that menopause is the start of the decline of estrogen but what happens when that hormone that has protected us for decades has started to fade. And what happens when estrogen, the quiet architect of balance in our bodies ...

Core Technology & Scientific Advancements - Scientists have developed a technology using human stem cells to grow whole brain organoids, offering potential for brain regeneration [3] - Induced pluripotent stem cells can be generated from various cell types (hair, skin, blood) and differentiated into brain-like structures suitable for transplantation [4] - The developed brain-like structures feature vascular networks crucial for graft survival, formed by smooth muscle cells, pericytes, macrophages, and the immune system [6] - The organoids exhibit cortical layer formation, essential for cognitive functions [7][8] - The organoids demonstrate multi-region integration, communicating and integrating with subcortical regions like the midbrain and hindbrain [8][9] - The brain-like structures exhibit early expression of the blood-brain barrier [10][11] - The integrated organ-like structures communicate through electrical function, indicating functional neural activity [11] Clinical & Translational Potential - Transplantable stem cell lines are already in Phase 2 and Phase 3 clinical trials globally [5] - The technology is reproducible, with 80% reproducibility across multiple cell lines based on marker analysis [9] - Pre-clinical studies in small and large animal models are underway to assess cognitive behavior and structural recovery after injury and potential transplantation [12][13] - The goal is to move the field of transplantation forward and potentially initiate Phase 1 studies within the next five years [15]

Core Argument - The prevailing aging models inadequately address the role of persistent pathogens (viruses, bacteria, parasites) as a significant driver of human aging and healthspan reduction [1] - Persistent pathogens can embed themselves in tissues and nerves, potentially driving various health problems later in life [2][3][4] - These pathogens can actively distort the signaling of human genes, impacting multiple hallmarks of aging [8] Pathogen Prevalence and Impact - Approximately 95% of individuals harbor one or more strains of herpes virus [5] - Around 11% of people in the US and up to 87% in some global regions carry the chronic parasite toxoplasma [6] - Persistent SARS-CoV-2 virus has been found in tissue samples months or years after initial infection [7] - Pathogens can drive mitochondrial dysfunction by hijacking host cell metabolism [10][11][12] - Viruses can integrate into telomeres, leading to shorter and more unstable telomeres [13][14] - Viral proteins can interact with and distort the signaling of human aging pathways [15] Proposed Solutions and Recommendations - The industry needs to seriously consider the impact of persistent pathogens when developing healthspan extending interventions [17] - Curbing the activity of pathogens should precede interventions like gene editing [18] - Integrating existing antiviral and anti-parasite medications into healthspan protocols is recommended [18] - Individuals with herpes simplex virus who regularly took anti-herpes virus medications had a 10 times lower risk of developing dementia [19] - Investment in new diagnostic test platforms to identify persistent pathogens is crucial [20][21] - Incorporating the activity of persistent pathogens into aging models is essential for successfully extending healthspan [22]