KYV-101 has the potential to deliver durable, drug-free, disease-free remission in myasthenia gravis and set a new treatment standard for stiff person syndrome Innovative FDA-aligned KYSA-6 Phase 3 trial design for myasthenia gravis supports clear and rapid path to BLA Webcast today August 28th, at 11 am ET EMERYVILLE, Calif., Aug. 28, 2025 (GLOBE NEWSWIRE) -- Kyverna Therapeutics, Inc. (Nasdaq: KYTX), a clinical-stage biopharmaceutical company focused on developing cell therapies for patients with autoimm ...

Core Viewpoint - Avis Budget Group's shares declined nearly 6% following Hertz Global Holdings' announcement of a sales agreement with Amazon Autos, highlighting competitive pressures in the car rental industry [1][2]. Group 1: Competitive Landscape - Hertz Global Holdings has secured a significant sales channel by partnering with Amazon Autos, allowing it to sell used cars through Amazon's platform [2][4]. - The partnership with Amazon positions Hertz advantageously in the online retail space, which is crucial for attracting customers seeking vehicles [2][4]. - Both Avis and Hertz offer similar services and operate in comparable markets, making competitive differentiation essential [5]. Group 2: Strategic Implications for Avis - In response to Hertz's new sales channel, Avis may need to explore similar partnerships or enhance existing sales efforts to remain competitive [6]. - The challenge for Avis lies in matching the scale and reach of Amazon, which may require significant strategic initiatives [6].

On Wednesday, William Blair initiated coverage on Kyverna Therapeutics Inc. KYTX, a small-cap biotechnology company focused on cell therapies for autoimmune disorders. Kyverna's lead CAR T-cell therapy candidate, KYV-101, is advancing through late-stage clinical development with registrational trials for stiff person syndrome and myasthenia gravis, and two ongoing multi-center Phase 1/2 trials for patients with lupus nephritis. Topline data for the registrational Phase 2 trial of KYV-101 in stiff person syn ...

Core Viewpoint - Avis Budget Group's stock has been downgraded from Buy to Underperform by BofA Securities, with a price target reduction from $120 to $113 due to unfavorable industry fundamentals and macroeconomic conditions [1][4]. Industry Overview - The U.S. rental car industry is experiencing pricing and demand pressures that are expected to negatively impact Avis Budget's earnings in the latter half of 2025 and into 2026 [1]. - A Bank of America survey indicates a decline in consumer expectations for increased travel spending over the next three months compared to the previous year, suggesting a softer pricing environment [2]. Company Performance - Avis Budget's growth initiatives, such as the premium-focused Avis First program and a fleet management partnership with Waymo, are recognized as positive long-term strategies but are not expected to significantly enhance near-term earnings [3]. - The analyst has revised EBITDA estimates to $0.9 billion for 2025 and $1.03 billion for 2026, down from previous forecasts of $0.95 billion and $1.2 billion [4]. - Expected sales for 2025 are projected at $8.09 billion, with an EPS of $9.43 [4]. Stock Performance - Avis Budget Group's stock is currently down 4.83%, trading at $149.06 at the time of publication [4].

About Anixa Biosciences, Inc. Fourth Cohort Receiving 30x Initial Dose with No Dose-Limiting Toxicities Observed to Date SAN JOSE, Calif., Aug. 18, 2025 /PRNewswire/ -- Anixa Biosciences, Inc. ("Anixa" or the "Company") (NASDAQ: ANIX), a biotechnology company focused on the treatment and prevention of cancer, today announced that the second patient in the fourth dose cohort has been treated in the ongoing Phase 1 clinical trial evaluating the Company's novel chimeric antigen receptor-T cell (CAR-T) therapy ...

The allowed claims in this patent encompass core methods and compositions that are fundamental to Anixa's innovative CAR-T approach. Anixa's CAR-T platform is specifically designed to address the long-standing challenges of applying CAR-T therapies to solid tumors, positioning the program as a potential breakthrough in immuno-oncology. This newly issued patent builds on Anixa's growing portfolio of CAR-T intellectual property, collectively designed to protect the platform's use across multiple tumor types. ...

Core Insights - Avis Budget Group, Inc. (CAR) reported second-quarter 2025 results that were narrower than expected, with adjusted earnings per share of 10 cents, missing the Zacks Consensus Estimate by 95.1% and decreasing 75.6% from the previous year [1][8] - Revenues for the quarter were $3 billion, slightly below consensus estimates and showing a marginal year-over-year decline [1][8] - Following the earnings release on July 29, CAR's stock experienced a 21.9% decline due to disappointing earnings and revenue results [1][8] Financial Performance - Year-to-date, CAR shares have surged 97.5%, contrasting with a 3.3% decline in the industry and a 7.3% growth in the Zacks S&P 500 composite [2] - Revenues from the Americas segment were $2.3 billion, reflecting a 1% decline from the previous year and missing the estimate of $2.4 billion [3] - International revenues totaled $707 million, down 3% year-over-year, also missing the estimate of $698.2 million [3] - Adjusted EBITDA for the company was $277 million, up 29% from the prior year, with the Americas segment contributing $220 million (an 18% increase) and international operations reporting $82 million (a 71% increase) [4] Balance Sheet and Cash Flow - At the end of Q2 2025, Avis Budget had cash and cash equivalents of $541 million, up from $516 million at the end of Q1 2025 [5] - Corporate debt increased to $6.1 billion from $5.9 billion in the previous quarter [5] - The company generated $837 million in net cash from operating activities, with adjusted free cash flow utilized at $17 million and capital expenditure at $53 million [5]

Check This Out: Jim Cramer Says 'No' To This Auto Parts Provider, But 'Yes' To Another Leading and Lagging Sectors U.S. stocks traded mixed toward the end of trading, with the Nasdaq Composite gaining around 0.5% on Wednesday. The Dow traded up 0.02% to 44,639.69 while the NASDAQ rose 0.46% to 21,195.54. The S&P 500 also rose, gaining, 0.21% to 6,384.38. Utilities shares jumped by 0.8% on Wednesday. In trading on Tuesday, energy stocks dipped by 1.2%. Top Headline Crude oil inventories in the U.S. increased ...

Avis stock has soared over the last three months, but second-quarter results couldn't live up to the hype. Shares of Avis Budget Group (CAR -15.51%) were moving in the wrong direction today after the rental car leader came up short in its second-quarter earnings report. As of 1:16 p.m. ET, the stock was down 15.4% on the news. Avis also announced a multiyear strategic partnership with Waymo to launch fully autonomous ride-hailing in Dallas, where Avis will be responsible for fleet management, and it launche ...

Financial Data and Key Metrics Changes - The company is experiencing challenges with revenue per day (RPD) due to tariffs and recalls affecting fleet management, which has led to a conservative approach in accounting for gross depreciation [60][64]. - The company expects a normalized EBITDA of at least $1 billion going forward, despite current challenges [80][81]. Business Line Data and Key Metrics Changes - The introduction of Avis First aims to redefine the premium car rental experience, with expectations that it will capture a significant share of rental days similar to premium airline seats [106][112]. - The company is focusing on maintaining a fleet of newer, low-mileage vehicles for the Avis First offering, which may involve reallocating resources within the existing fleet [50][51]. Market Data and Key Metrics Changes - The overall car rental market is competitive, with the company aiming to differentiate itself through innovative offerings rather than competing solely on price [95]. - The company is seeing signs of demand recovery in the leisure segment, which is stronger than the commercial segment [58]. Company Strategy and Development Direction - The company is prioritizing value-creating innovation as a core responsibility, with a focus on enhancing customer experience and operational efficiency [9][10]. - The partnership with Waymo is seen as a strategic move to position the company within the autonomous vehicle ecosystem, leveraging its fleet management expertise [30][32]. Management's Comments on Operating Environment and Future Outlook - Management acknowledges the current operational challenges due to tariffs and recalls but remains optimistic about long-term growth opportunities in the mobility ecosystem [65][66]. - The company is committed to maintaining a disciplined approach to investments, ensuring that growth translates into free cash flow while enhancing customer experience [102][103]. Other Important Information - Avis First has been launched in over a dozen locations, with plans to expand to over 50 markets by the end of the year [22][112]. - The company is actively managing its fleet to adapt to market conditions, including being cautious with vehicle purchases in light of tariff uncertainties [85][86]. Q&A Session Summary Question: Confirmation of competitive process for Waymo partnership - Management indicated that discussions with multiple AV parties were ongoing, and both parties were aware of the competitive landscape [37]. Question: Long-term vision for Avis Budget's business model - The company sees its core competency in mega fleet management continuing, with potential expansion into autonomous ride-hailing as a future growth area [40][41]. Question: Bandwidth for future partnerships - Management expressed confidence in their capacity to take on future partnerships while maintaining focus on the core rental car business [47]. Question: Fleet considerations for Avis First - The company plans to include more premium vehicles in the fleet for Avis First, ensuring a high-quality customer experience [50][51]. Question: Guidance on RPD and market conditions - Management noted that RPD has been challenged but is seeing signs of improvement due to tightening industry supply and strong leisure demand [58][92]. Question: Revenue model for AV strategy - The specifics of the revenue model for the Waymo partnership are not disclosed, but management emphasized alignment on profitability variables [70][71]. Question: Measuring success of investments - The company evaluates investments based on growth, free cash flow generation, and customer experience enhancement [102][103].