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Summary of C4 Therapeutics FY Conference Call Company Overview - C4 Therapeutics is a targeted protein degradation company focused on developing medicines that utilize the body's natural system to destroy disease-causing proteins rather than inhibiting them [4][5] - The company is celebrating its 10th anniversary and currently has two active clinical programs: - **Sensitamide**: An IKZF1/3 degrader for multiple myeloma, with plans for further studies in early 2026 [4][5] - **EGFR L858R degrader**: In phase one with Beta Pharmaceuticals in China, targeting a specific mutation [4][5] - C4 has collaborations with Roche, Merck KGAA, and a completed collaboration with Biogen [5] - Recent financing provides operational runway through the end of 2028 [6] Core Product Insights Sensitamide - Designed as a highly targeted and potent degrader of IKZF1 and IKZF3, which are implicated in myeloma and lymphoma proliferation [7] - Key features include: - Low protein binding, allowing for effective drug concentration in the bone marrow [7] - No renal clearance, enabling treatment for patients with renal insufficiency [8] - A half-life of 48 hours, facilitating dosing [8] - Clinical data indicates: - A 33% overall response rate across all patients, with a 53% response rate in late-line refractory patients at the highest dose [12] - Mild toxicity profile with no significant gastrointestinal or neurological side effects [10] - T cell activation observed, enhancing immune response [13] Market Dynamics and Competitive Landscape - The myeloma treatment landscape is evolving, with a shift towards introducing effective treatments earlier in the therapy regimen [18] - Sensitamide is positioned to compete against CAR-T and BITE therapies, with potential for combination therapies to enhance efficacy [20][42] - The company anticipates a growing market for late-line treatments as newer agents lead to longer patient survival but not cures [42] - Estimated market opportunity for Sensitamide is projected at $1 billion to $1.5 billion in late-line settings and $2.5 billion to $4 billion when considering second-line treatments [43] Clinical Development Strategy - Plans to initiate a phase one B study in early 2026, combining Sensitamide with Pfizer's ELREXFIO [21][22] - The study will evaluate multiple dose levels to determine optimal safety and efficacy [22] - A non-randomized phase two study will also be initiated to confirm efficacy in late-line patients [24] - The strategy includes potential for accelerated approval based on early efficacy signals [23][24] Collaboration and Future Directions - Collaboration with Pfizer is focused on leveraging expertise in BITEs for the development of combination therapies [38][39] - The company is open to exploring additional combinations as resources allow, including with CD38 and carfilzomib [25] - Continuous updates on trial progress and safety data will be provided to investors [40] Conclusion - C4 Therapeutics is well-positioned in the evolving myeloma treatment landscape with its innovative approach to targeted protein degradation, particularly through Sensitamide, which shows promising clinical data and a strong market opportunity [4][43]

Core Insights - C4 Therapeutics, Inc. reported a quarterly loss of $0.44 per share, which was better than the Zacks Consensus Estimate of a loss of $0.47, representing an earnings surprise of +6.38% [1] - The company generated revenues of $11.23 million for the quarter ended September 2025, exceeding the Zacks Consensus Estimate by 72.77%, although this was a decline from $15.36 million in the same quarter last year [2] - C4 Therapeutics shares have underperformed, losing approximately 34.2% since the beginning of the year, contrasting with the S&P 500's gain of 15.6% [3] Earnings Outlook - The current consensus EPS estimate for the upcoming quarter is -$0.29 on revenues of $9.5 million, and for the current fiscal year, it is -$1.46 on revenues of $29.7 million [7] - The estimate revisions trend for C4 Therapeutics was favorable prior to the earnings release, resulting in a Zacks Rank 2 (Buy) for the stock, indicating expected outperformance in the near future [6] Industry Context - The Medical - Biomedical and Genetics industry, to which C4 Therapeutics belongs, is currently ranked in the top 41% of over 250 Zacks industries, suggesting a favorable outlook compared to lower-ranked industries [8] - Empirical research indicates a strong correlation between near-term stock movements and trends in earnings estimate revisions, which can be tracked by investors [5]

Financial Performance - Total current assets decreased from $257,767,000 as of December 31, 2024, to $206,864,000 as of September 30, 2025, representing a decline of approximately 19.7%[20] - Revenue from collaboration agreements for the three months ended September 30, 2025, was $11,230,000, down 26.1% from $15,362,000 for the same period in 2024[23] - Total operating expenses increased to $45,642,000 for the three months ended September 30, 2025, compared to $43,606,000 for the same period in 2024, marking an increase of 4.7%[23] - The net loss for the three months ended September 30, 2025, was $32,166,000, compared to a net loss of $24,666,000 for the same period in 2024, reflecting an increase in loss of 30.4%[23] - For the nine months ended September 30, 2025, the net loss was $84.5 million, compared to a net loss of $70.7 million for the same period in 2024, reflecting an increase in losses of approximately 19.7%[38] - The company reported a net loss of $84.5 million for the nine months ended September 30, 2025, compared to a net loss of $70.7 million for the same period in 2024, resulting in an accumulated deficit of $718.2 million as of September 30, 2025[167] Assets and Liabilities - Cash and cash equivalents increased from $55,499,000 as of December 31, 2024, to $58,809,000 as of September 30, 2025, an increase of approximately 4.1%[20] - The accumulated deficit grew from $633,699,000 as of December 31, 2024, to $718,207,000 as of September 30, 2025, indicating an increase of 13.3%[20] - The total liabilities decreased from $133,616,000 as of December 31, 2024, to $111,080,000 as of September 30, 2025, a reduction of approximately 16.8%[20] - The total stockholders' equity decreased from $215,986,000 as of December 31, 2024, to $154,408,000 as of September 30, 2025, a decline of approximately 28.5%[20] - As of September 30, 2025, the company had cash, cash equivalents, and marketable securities totaling approximately $199.8 million[140] Research and Development - Research and development expenses for the nine months ended September 30, 2025, were $79,258,000, slightly up from $78,124,000 for the same period in 2024, an increase of 1.5%[23] - The company continues to focus on research and development activities, leveraging its proprietary TORPEDO platform to advance targeted oncology programs[36] - The company expects research and development expenses to continue to increase substantially in connection with planned preclinical and clinical development activities[124] - The company anticipates significant operating losses to continue as it advances preclinical programs and product candidates through clinical development[139] - Cemsidomide, the company's lead product candidate, is in clinical development for multiple myeloma and has shown compelling anti-myeloma activity in recent trials[114] Collaborations and Agreements - Under the Pfizer Agreement, Pfizer will supply elranatamab for a Phase 1b trial at no cost, while the company will sponsor and pay for the trial costs[58] - The MKDG Agreement includes an upfront cash payment of $16 million and potential milestone payments totaling approximately $740 million, plus tiered royalties on net sales[60] - The company earned a $1 million milestone payment in April 2025 for achieving a discovery milestone related to the MKDG collaboration[60] - The Betta Pharma License Agreement includes an upfront cash payment of $10.0 million and potential milestone payments of up to $357.0 million, plus tiered royalties on net sales in Greater China[66] - The company received a $45.0 million nonrefundable upfront payment from Biogen as part of the collaboration agreement[86] Market and Competition - The company faces substantial competition in the targeted protein degradation (TPD) space from numerous biotechnology and pharmaceutical firms, including Arvinas, Inc. and BioTheryX, Inc.[212] - Competitors possess significantly greater financial resources and expertise in R&D, manufacturing, and regulatory approvals, which may hinder the company's market position[214] - The competition includes not only other TPD therapies but also small molecule, antibody, T cell, and gene therapies, which could impact the company's market entry[213] Financial Strategy and Future Outlook - The company may need to obtain substantial additional financing to support its operations and long-term business plan, as it cannot estimate future capital requirements due to various risks and uncertainties[147] - The company has entered into collaborations with partners such as Roche and Biogen, but does not have any committed external sources of funds as of September 30, 2025[147] - The company anticipates incurring significant expenses and increasing operating losses for at least the next several years due to ongoing research and development activities[168] - The company will need to raise substantial additional capital to fund product development and commercialization efforts[176] Clinical Trials and Regulatory Challenges - The company has not yet demonstrated the ability to successfully complete clinical trials or obtain marketing approvals for its product candidates[178] - The regulatory approval process for the company's novel product candidates may be more expensive and time-consuming compared to other therapeutics[188] - The company may face unforeseen expenses and challenges as it transitions from a research-focused entity to one capable of supporting commercial activities[179] - Clinical trials are lengthy and expensive, with significant uncertainty regarding outcomes, and the company may incur unexpected costs or delays[205]

Financial Performance - Total revenue for Q3 2025 was $11.2 million, a decrease from $15.4 million in Q3 2024, primarily due to an $8.0 million milestone from Biogen recognized in the previous year[9]. - Revenue from collaboration agreements decreased to $11.230 million in Q3 2025 from $15.362 million in Q3 2024, representing a decline of approximately 27.6%[24]. - Total operating expenses increased to $45.642 million in Q3 2025 compared to $43.606 million in Q3 2024, reflecting a rise of about 4.7%[24]. - Net loss for Q3 2025 was $32.2 million, compared to $24.7 million in Q3 2024, with net loss per share increasing to $0.44 from $0.35[11]. - Net loss for Q3 2025 was $32.166 million, compared to a net loss of $24.666 million in Q3 2024, indicating an increase in losses of about 30.4%[24]. - Net loss per share for Q3 2025 was $0.44, compared to $0.35 in Q3 2024, reflecting a worsening of approximately 25.7%[24]. - Total other income decreased to $2.246 million in Q3 2025 from $3.578 million in Q3 2024, a decline of about 37.2%[24]. - Weighted-average shares outstanding increased to 72,563,311 in Q3 2025 from 69,627,190 in Q3 2024, an increase of approximately 4.0%[24]. Research and Development - Research and Development (R&D) expenses for Q3 2025 were $26.0 million, down from $31.8 million in Q3 2024, mainly due to reduced clinical trial expenses for CFT1946[10]. - Research and development expenses were $25.989 million in Q3 2025, down from $31.838 million in Q3 2024, a decrease of approximately 18.5%[24]. - Cemsidomide demonstrated a 53% overall response rate at the highest dose level of 100 µg in the Phase 1 trial, supporting its potential best-in-class profile[3]. - C4 Therapeutics completed enrollment and dose escalation for the Phase 1 trial of cemsidomide in multiple myeloma, achieving a median duration of response of 9.3 months across all doses[4]. - The company plans to initiate the Phase 2 MOMENTUM trial in combination with dexamethasone in Q1 2026 and a Phase 1b trial in combination with elranatamab in Q2 2026[2][8]. - The company entered into a clinical trial collaboration with Pfizer for the combination of cemsidomide and elranatamab, with Pfizer supplying elranatamab at no cost for the upcoming trial[8]. Expenses - General and Administrative (G&A) expenses for Q3 2025 were $8.9 million, compared to $11.8 million in Q3 2024, reflecting lower stock-based compensation expenses[11]. - General and administrative expenses decreased to $8.920 million in Q3 2025 from $11.768 million in Q3 2024, a reduction of about 24.3%[24]. - Loss from operations increased to $34.412 million in Q3 2025 from $28.244 million in Q3 2024, an increase of approximately 22.0%[24]. - Impairment of long-lived assets recorded in Q3 2025 was $10.733 million, with no impairment reported in Q3 2024[24]. Cash Position - Cash, cash equivalents, and marketable securities as of September 30, 2025, were $199.8 million, down from $267.3 million as of December 31, 2024[12].

Core Insights - C4 Therapeutics, Inc. successfully raised $125 million in gross proceeds through an equity offering, extending its financial runway to the end of 2028, which is crucial for advancing its clinical programs, particularly for cemsidomide [1][2][6] - Cemsidomide has shown promising Phase 1 data in multiple myeloma, achieving a 53% overall response rate at the highest dose level, indicating a potential best-in-class profile [1][3][15] - The company is on track to initiate the next phases of cemsidomide development, including a Phase 2 MOMENTUM trial in combination with dexamethasone in Q1 2026 and a Phase 1b trial in combination with elranatamab in Q2 2026 [1][2][12] Financial Performance - Total revenue for Q3 2025 was $11.2 million, a decrease from $15.4 million in Q3 2024, primarily due to the absence of an $8 million milestone recognized in the previous year [8] - Research and Development (R&D) expenses for Q3 2025 were $26 million, down from $31.8 million in Q3 2024, attributed to reduced clinical trial expenses [9] - General and Administrative (G&A) expenses for Q3 2025 were $8.9 million, compared to $11.8 million in Q3 2024, mainly due to lower stock-based compensation [10] - The net loss for Q3 2025 was $32.2 million, compared to $24.7 million in Q3 2024, with a net loss per share of $0.44 [10][23] Clinical Development - C4 Therapeutics presented Phase 1 data showing cemsidomide's potential best-in-class profile in heavily pre-treated multiple myeloma patients, with a median duration of response of 9.3 months [3][15] - The company has entered into a collaboration with Pfizer to evaluate cemsidomide in combination with elranatamab, with C4T sponsoring the Phase 1b trial [3][4] - The upcoming Phase 2 MOMENTUM trial will evaluate cemsidomide in combination with dexamethasone in patients with relapsed/refractory multiple myeloma, aiming to enroll approximately 100 patients [14][15] Cash Position and Future Outlook - As of September 30, 2025, the company had cash, cash equivalents, and marketable securities totaling $199.8 million, down from $267.3 million at the end of 2024, but bolstered by the recent equity offering [13][21] - The company expects its current financial resources to support its operating plan through the end of 2028, allowing for continued development of its clinical programs [13][6]

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Core Viewpoint - C4 Therapeutics, Inc. is raising $125 million through an underwritten offering to fund the next phase of its cemsidomide multiple myeloma development, with potential additional proceeds of up to $225 million [1][5]. Group 1: Offering Details - The offering consists of 21,895,000 shares of common stock and pre-funded warrants to purchase up to 28,713,500 shares of common stock [2]. - The offering is priced at $2.47 per share of common stock and accompanying warrants, and $2.4699 per pre-funded warrant and accompanying warrants [4]. - The total gross proceeds from the offering are expected to be $125 million, with a potential total of $349.7 million if all warrants are exercised [5]. Group 2: Use of Proceeds - The net proceeds from the offering will primarily fund ongoing and planned clinical trials of cemsidomide, other research and development activities, and general corporate purposes [6]. Group 3: Company Overview - C4 Therapeutics is a clinical-stage biopharmaceutical company focused on targeted protein degradation science, aiming to develop new medicines for difficult-to-treat diseases [11]. - The company utilizes its TORPEDO® platform to design and optimize small-molecule medicines, which are intended to degrade disease-causing proteins and improve patient outcomes [11].

Core Insights - C4 Therapeutics has entered into a clinical trial collaboration and supply agreement with Pfizer to advance its research in targeted protein degradation for multiple myeloma treatment [1][2] Company Overview - C4 Therapeutics is a clinical-stage biopharmaceutical company focused on targeted protein degradation science, aiming to create innovative medicines that improve patient outcomes [4] - The company utilizes its TORPEDO platform to design and optimize small-molecule medicines for challenging diseases, with a focus on oncology [4] Clinical Trial Details - The upcoming Phase 1b trial will assess the safety and tolerability of cemsidomide, an IKZF1/3 degrader, in combination with elranatamab for patients with relapsed/refractory multiple myeloma [2][5] - The trial is expected to start in Q2 2026 and aims to establish an optimal dose for cemsidomide when combined with elranatamab [2] - Pfizer will supply elranatamab at no cost, while C4 Therapeutics will sponsor and conduct the trial [2] Product Information - Cemsidomide is an investigational small-molecule degrader that has shown promising safety and tolerability, as well as strong anti-myeloma activity in previous trials [5] - Two additional clinical trials for cemsidomide are planned: a Phase 2 trial in combination with dexamethasone expected to start in Q1 2026, and the aforementioned Phase 1b trial [5] Market Potential - The collaboration with Pfizer positions cemsidomide to potentially enhance treatment regimens for multiple myeloma, aiming to improve patient outcomes in earlier lines of therapy [3] - Elranatamab is on track to become a standard of care BCMAxCD3 bispecific antibody in a growing market for multiple myeloma treatments [3]

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