Crinetics Pharmaceuticals FY Conference Summary Company Overview - **Company**: Crinetics Pharmaceuticals (NasdaqGS:CRNX) - **Date of Conference**: January 13, 2026 - **Key Speaker**: Scott Struthers, CEO Core Industry and Company Insights Achievements and Developments - **Palsinify Approval**: Received broad label approval for Palsinify for the treatment of acromegaly on its PDUFA date, marking a significant milestone for the company [3][7] - **Successful Launch**: The launch of Palsinify has been successful, with over 200 patients enrolled in the last quarter and more than 125 unique prescribers involved [8][9] - **Pipeline Expansion**: Positive phase two data reported for atumelnant, with ongoing phase three studies for carcinoid syndrome and new compound 9682 in phase one/two studies for neuroendocrine tumors (NETs) [3][4] Financial Position - **Funding**: The company has approximately $1.4 billion in the bank, providing a solid foundation for operations through 2030 [4] - **Revenue Generation**: Achieved over $5 million in revenue last year, with expectations for growth as Palsinify gains market acceptance [11] Patient Engagement and Market Strategy - **Patient Services**: Implemented a comprehensive patient services program, including a Quick Start program to facilitate access to Palsinify [10][13] - **Market Access**: Focus on expanding prescriber base and activating patients who have previously settled with their conditions [34][35] - **Payer Engagement**: Strong efforts to communicate the value of Palsinify to payers, with CVS Caremark covering over 27 million lives [36][38] Pipeline and Future Prospects Palsinify and Acromegaly - **Market Potential**: There are approximately 36,000 patients with acromegaly in the U.S., with only 3,000 currently on standard care, indicating significant room for growth [14][15] - **Blockbuster Potential**: The CEO expressed confidence that Palsinify could become a blockbuster drug, aiming to help more than 5,000 patients per $1 billion in revenue [15] Atumelnant and CAH - **Clinical Development**: Atumelnant is positioned as a treatment for congenital adrenal hyperplasia (CAH), with promising phase two data showing significant reductions in adrenal androgens [20][25] - **Patient Population**: Approximately 12,000 patients in the U.S. are affected by CAH, with a focus on achieving normal hormone levels through treatment [25] 9682 and Neuroendocrine Tumors - **New Platform**: 9682 is being developed as a drug targeting agent for SST2-positive expressing solid tumors, with a phase 1/2 trial currently underway [27][28] - **Market Opportunity**: There are 11,000-21,000 patients currently treated for neuroendocrine tumors, with many more not receiving treatment [28] Key Milestones and Future Outlook - **2030 Vision**: The company aims to emerge as a premier endocrinology business with two marketed products and four approved indications by 2030 [30] - **Clinical Pipeline**: Anticipates having seven clinical pipeline candidates in development, with ongoing investments in discovery labs [30] Additional Insights - **Patient-Centric Approach**: Emphasis on patient stories and experiences to enhance engagement and support for Palsinify [12][13] - **Regulatory Strategy**: The company is actively monitoring and managing clinical trials to ensure high-quality data and compliance [45][46] This summary encapsulates the key points from the Crinetics Pharmaceuticals FY Conference, highlighting the company's achievements, pipeline developments, financial position, and strategic outlook for the future.

JANUARY 2026 Beyond Innovation to Impact: Building the Premier Endocrinology Business J.P. Morgan Healthcare Conference Angela Living with Acromegaly Forward Looking Statements and Legal Disclaimers Forward Looking Statements: This presentation contains forward-looking statements. Crinetics Pharmaceuticals, Inc. ("Crinetics," the "company," "we," "us," or "our") cautions you that all statements other than statements of historical facts contained in this presentation are forward-looking statements. Such forw ...

Core Viewpoint - Crinetics Pharmaceuticals has granted stock options and restricted stock units to new non-executive employees as part of its 2021 Employment Inducement Incentive Award Plan, aimed at attracting talent to the company [1][2]. Group 1: Stock Options and RSUs - The Compensation Committee granted a total of 37,575 stock options and 25,525 RSUs to 10 new non-executive employees [1]. - The stock options have an exercise price of $53.25 per share, equal to the closing price on January 9, 2026 [2]. - The stock options will vest over four years, with 25% vesting on the one-year anniversary and the remainder vesting in 36 equal monthly installments, contingent on continued employment [2]. Group 2: 2021 Inducement Plan - The 2021 Inducement Plan is designed for granting equity awards to individuals who were not previously employees or who have had a bona fide period of non-employment [2]. - The RSUs will also vest over four years in equal annual installments starting on the one-year anniversary, subject to continued employment [2]. Group 3: Company Overview - Crinetics Pharmaceuticals is focused on transforming the treatment of endocrine diseases and related tumors through innovative therapies [3]. - The company specializes in targeting G-protein coupled receptors (GPCRs) with small molecules tailored for specific pharmacological properties [3]. Group 4: Product Pipeline - Crinetics' lead product, PALSONIFY™ (paltusotine), is the first oral treatment approved by the U.S. FDA for adults with acromegaly who have not responded adequately to surgery [4]. - The company has a pipeline of over 10 disclosed programs, including late-stage candidates for congenital adrenal hyperplasia and ACTH-dependent Cushing's syndrome, as well as discovery programs for various endocrine conditions [4].

Core Viewpoint - Crinetics Pharmaceuticals, Inc. has announced a public offering of 7,620,000 shares at a price of $45.95 per share, aiming to raise approximately $350 million in gross proceeds before expenses [1][2]. Group 1: Offering Details - The offering consists entirely of shares sold by Crinetics, with a 30-day option for underwriters to purchase an additional 1,143,000 shares [1]. - The expected closing date for the offering is around January 8, 2026, pending customary closing conditions [1]. Group 2: Use of Proceeds - The net proceeds from the offering will be utilized for commercial activities related to the launch of PALSONIFY™, R&D of product candidates, and general corporate purposes, including capital expenditures and working capital [2]. - Crinetics may also consider using a portion of the proceeds for in-licensing, acquiring, or investing in complementary businesses or technologies, although there are no current commitments to do so [2]. Group 3: Company Overview - Crinetics Pharmaceuticals focuses on developing novel therapeutics for endocrine diseases and related tumors, with expertise in targeting G-protein coupled receptors (GPCRs) [6]. - The company's lead product, PALSONIFY™ (paltusotine), is the first oral treatment approved by the FDA for adults with acromegaly who have not responded adequately to surgery [7]. - Crinetics has a pipeline of over 10 disclosed programs, including candidates for congenital adrenal hyperplasia and neuroendocrine tumors, addressing various endocrine conditions [7].

Core Insights - Crinetics Pharmaceuticals, Inc. is preparing to host a conference call on January 5, 2026, to discuss the commercialization of PALSONIFY, the first FDA-approved oral treatment for acromegaly, and to share results from the Phase 2 trial of atumelnant for congenital adrenal hyperplasia [1][6] Group 1: Company Overview - Crinetics focuses on developing treatments for endocrine diseases, utilizing small molecules that target G-protein coupled receptors (GPCRs) [2] - The company's pipeline includes atumelnant for congenital adrenal hyperplasia and ACTH-dependent Cushing's syndrome, as well as CRN09682 for SST2 expressing tumors [2] Group 2: Financial Performance - Evercore ISI has maintained an "Outperform" rating for CRNX, raising the price target from $80 to $90, despite the stock price being $52.57 and a negative price-to-earnings (P/E) ratio of -10.29 [3] - The company has a high price-to-sales ratio of 2,856.31 and an elevated enterprise value to sales ratio of 2,816.08, indicating that investors are paying a premium for its sales [4] - Crinetics has a negative earnings yield of -9.72%, but maintains a low debt-to-equity ratio of 0.046, reflecting minimal reliance on debt [5] - The company exhibits a strong liquidity position with a current ratio of 15.12, indicating it can comfortably cover its short-term liabilities [5]

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Core Viewpoint - Nord Precious Metals Inc. has entered into a definitive asset purchase agreement to acquire four mining leases in the Gowganda Silver Camp, significantly expanding its silver tailings resource by approximately 2.9 million ounces of silver at a time when silver prices are at record levels [1][2]. Transaction Details - The acquisition consolidates Nord's position in a historically significant silver-cobalt district in Ontario, which has recently implemented a new permitting framework and launched a $500 million Critical Minerals Processing Fund [1]. - The transaction involves a cash payment of $1,000,000, $1,250,000 in Nord shares at a deemed price of $0.284 per share, a 3.0% net smelter returns royalty, and deferred consideration of $3,750,000 over three years [9]. - The transaction is an arms-length deal with no finder fees, subject to certain closing conditions including approval from the TSX Venture Exchange [6]. Resource Information - The Gowganda camp has a historical mineral resource estimate indicating nearly 3 million ounces of silver in tailings, with a significant portion classified as Indicated [2][4]. - The resource estimate is based on extensive drilling and verification processes, ensuring confidence in the distribution of silver within the tailings deposit [3][4]. - The historical resource estimate is not currently classified as a current resource, and further work is required to confirm the original assays and assumptions in light of current metal prices [4]. Strategic Positioning - Nord operates TTL Laboratories, the only permitted high-grade milling facility in the Cobalt Camp, which supports its integrated processing strategy for multiple metal recovery streams [10][12]. - The company's flagship Castle property has delineated 7.56 million ounces of silver in inferred resources, further enhancing its strategic position in the silver and critical minerals market [11]. - The integrated processing strategy aims to recover high-grade silver while also extracting critical minerals like cobalt and nickel, positioning Nord within Ontario's emerging critical minerals supply chain [12].

Crinetics Pharmaceuticals Conference Call Summary Company Overview - **Company**: Crinetics Pharmaceuticals (NasdaqGS:CRNX) - **Date**: January 05, 2026 - **Key Products**: Palsonify (for acromegaly), Atumelnant (for congenital adrenal hyperplasia, CAH) Key Points Industry and Market Context - The call discussed the acromegaly market, highlighting approximately **36,000 people** living with the condition in the U.S. [7] - The company aims to address the challenges faced by patients with acromegaly, many of whom have been stalled by inconsistent treatments [7] Product Launch and Performance - **Palsonify**: - Launched successfully in Q4 2025, with over **200 enrollment forms** processed [12] - Achieved **$5 million** in unaudited net revenue for the fourth quarter [12] - The launch strategy focuses on engaging both actively managed patients and those who have not been diagnosed [9] - Positive patient feedback has been reported, with many switching from injectable therapies to Palsonify [10] - **Atumelnant**: - Positioned to transform CAH treatment, aiming to provide a new standard of care without the side effects of high-dose steroids [5] - Data indicates a robust benefit-risk profile, with ongoing phase three studies planned [6] - The drug is designed to selectively block the ACTH receptor, potentially leading to significant reductions in adrenal androgens [17] Clinical Data and Studies - **Atumelnant Phase 2 Study**: - Cohort four results showed sustained reductions in androstenedione (A4) levels while tapering glucocorticoids [22] - A4 reductions were observed even with glucocorticoid doses reduced to physiological levels [24] - The study demonstrated a **67% reduction** in A4 levels in cohort four [33] - **Safety Profile**: - Atumelnant has been well tolerated with no serious adverse events reported across over **750 weeks** of patient exposure [30] - Common adverse events included headache and fatigue, typical for this patient population [29] Future Plans and Expectations - The company is optimistic about the upcoming **phase 3 CALM CAH study**, targeting **150 patients** to evaluate Atumelnant's safety and efficacy [30] - The study aims to demonstrate a statistically significant difference in achieving normal A4 levels while on physiological glucocorticoid doses [31] - Crinetics plans to continue expanding its pipeline, with additional candidates like paltusotine for carcinoid syndrome and CRN9682 for SST2-expressing cancers [36] Commercial Strategy - The company emphasizes commercial execution as a top priority, with a focus on building relationships with healthcare providers and payers [11] - Early formulary inclusions have been secured, and the company is actively engaging with payers to ensure patient access [12][70] Additional Insights - The company is committed to addressing the long diagnostic delays for acromegaly, which can take **5 to 10 years** [9] - The patient ambassador program aims to leverage patient experiences to enhance awareness and support for Palsonify [13] Conclusion Crinetics Pharmaceuticals is positioned for growth in the endocrine treatment market, with successful product launches and promising clinical data for Atumelnant. The company is focused on improving patient outcomes and expanding its market presence through strategic commercial initiatives and ongoing clinical studies.

Core Insights - Crinetics Pharmaceuticals reported unaudited and preliminary net product revenue of over $5 million for PALSONIFY in the fourth quarter of 2025, with over 200 enrollment forms submitted by the end of December [2][4][5] - Positive topline results from the fourth cohort of the Phase 2 congenital adrenal hyperplasia (CAH) study of atumelnant were announced, showing a 67% mean reduction in androstenedione levels and enabling 88% of participants to successfully reduce glucocorticoid doses to physiological levels [1][8][9] Company Performance - The launch of PALSONIFY, approved by the FDA on September 25, 2025, has been characterized by strong execution, with over 200 enrollment forms and a broad prescriber base [3][4][7] - Feedback from patients, physicians, and payers has been positive, leading to early formulary inclusions by payers [4][5] Clinical Study Results - The fourth cohort of the Phase 2 TouCAHn trial involved 10 patients with classic CAH, with treatment resulting in significant reductions in androstenedione levels [5][8] - Atumelnant was well-tolerated, with no serious adverse events reported, and a favorable benefit/risk profile maintained throughout the study [11][14] Future Outlook - Crinetics plans to host an investor conference call to discuss the topline results from the study, indicating ongoing engagement with investors and stakeholders [15][16] - Atumelnant is positioned as a potential transformational treatment for congenital adrenal hyperplasia and ACTH-dependent Cushing's syndrome, with ongoing Phase 3 clinical development [17][20]