[Form 8-K Current Report](index=1&type=section&id=Form%208-K%20Current%20Report) This report outlines iBio, Inc.'s Form 8-K filing, covering registrant details, financial results, and associated exhibits [Registrant Information](index=1&type=section&id=Registrant%20Information) This section provides iBio, Inc.'s basic registrant information, including trading symbol, exchange, and report date - The report was filed by iBio, Inc. on May 2, 2025[2](index=2&type=chunk) Registrant Details | Category | Detail | | :--- | :--- | | **Registrant Name** | iBio, Inc. | | **State of Incorporation** | Delaware | | **Commission File Number** | 001-35023 | | **Principal Executive Office** | 11750 Sorrento Valley Road, Suite 200, San Diego, California 92121 | | **Trading Symbol** | IBIO | | **Exchange** | The Nasdaq Stock Market LLC | [Item 2.02 Results of Operations and Financial Condition](index=2&type=section&id=Item%202.02%20Results%20of%20Operations%20and%20Financial%20Condition) iBio, Inc. announced Q1 2025 financial results via a furnished press release, limiting legal liabilities - The company announced its financial results for the quarter ended March 31, 2025, through a press release issued on May 2, 2025[5](index=5&type=chunk) - The information in the press release (Exhibit 99.1) is considered "furnished" and not "filed," meaning it is not subject to the liabilities of Section 18 of the Securities Exchange Act of 1934 and is not incorporated by reference into other SEC filings[6](index=6&type=chunk) [Item 9.01 Financial Statements and Exhibits](index=2&type=section&id=Item%209.01%20Financial%20Statements%20and%20Exhibits) This section lists Form 8-K exhibits, primarily the press release detailing the company's financial results Exhibits Furnished | Exhibit Number | Exhibit Description | | :--- | :--- | | 99.1 | Press Release, issued by iBio, Inc. dated May 2, 2025 | | 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

Core Viewpoint - iBio, Inc. reported significant progress in its financial position and pipeline development during the third quarter of fiscal 2025, including a successful equity raise and promising data for its lead therapeutic candidates [2][4]. Financial Results - For the third quarter ended March 31, 2025, iBio reported R&D expenses of approximately $1.9 million, an increase of about $1.0 million compared to $0.9 million in the same period of 2024, primarily due to higher spending on consultants, supplies, and personnel [7]. - General and administrative (G&A) expenses for the same period were approximately $3.0 million, up from $2.7 million in 2024, with the increase attributed to IT costs, consulting fees, and franchise taxes [7]. - The net loss from continuing operations for the third quarter was approximately $4.9 million, or $0.49 per share, compared to a net loss of approximately $2.6 million, or $0.71 per share, in the same period of fiscal 2024 [7]. - As of March 31, 2025, cash, cash equivalents, and restricted cash totaled approximately $5.2 million, which increased to approximately $10.5 million following a warrant inducement transaction in April 2025 [7]. Corporate Updates - iBio successfully transitioned to trading on the Nasdaq Stock Exchange under the ticker symbol "IBIO," enhancing visibility and liquidity, and aligning with its strategy to attract long-term institutional investors [7]. - The company reported promising non-human primate data for IBIO-600, a long-acting anti-myostatin antibody, indicating extended half-life and dose-dependent muscle growth [7]. - iBio in-licensed a first-in-class Activin E antibody from AstralBio, expanding its pipeline focused on cardiometabolic diseases and obesity [7]. - The company raised $6.2 million in gross proceeds through a warrant inducement transaction, strengthening its balance sheet and providing additional working capital for pipeline advancements [7].

Core Points - iBio, Inc. has entered into an agreement with existing institutional investors to exercise warrants for 5,626,685 shares at a reduced price of $1.11 per share, generating approximately $6.2 million in gross proceeds [1][2] - In exchange for exercising the existing warrants, investors will receive new warrants to purchase up to 11,253,370 shares at an exercise price of $0.86, expiring in five years [2] - The transaction is expected to close around April 30, 2025, pending customary closing conditions [2][3] Financial Details - The gross proceeds from the warrant exercise will be approximately $6.2 million before deducting advisory fees and other expenses [1] - The new warrants allow for the purchase of shares at a significantly lower price compared to the existing warrants [2] Company Overview - iBio, Inc. is a biotech company focused on developing precision antibody therapies using AI and advanced computational biology for various diseases [6] - The company aims to transform drug discovery and accelerate development timelines to address unmet medical needs [6]

Core Insights - iBio, Inc. has announced promising pharmacokinetics data for IBIO-600, a long-acting anti-myostatin antibody, suggesting a potential human half-life of up to 130 days, which could position it as a best-in-class treatment for muscle preservation and weight loss [1][4][5] - The company is on track to submit a regulatory application for IBIO-600 in Q1 2026, highlighting its commitment to innovation in obesity treatment [1][5] Group 1: IBIO-600 Development - The pharmacokinetics study involved non-human primates (NHPs) and indicated a half-life of 40 to 52 days in NHPs, with human estimates ranging from 57 to 130 days [4] - The study demonstrated a dose-dependent increase in lean mass and a reduction in fat mass, with the low-dose group showing a 3.1% increase in lean mass and the high-dose group a 5.1% increase after 8 weeks [3] - The potential for a dosing schedule of once every 3 to 6 months could significantly reduce the treatment burden for patients [4][5] Group 2: Activin E Antibody - iBio has also disclosed preclinical data for a first-in-class Activin E antibody, which effectively blocks Activin E signaling and shows promise as a novel obesity treatment [5] - In an exploratory study with obese mice, the Activin E antibody as a monotherapy resulted in a 4% fat-selective weight loss and an 18% reduction in total body fat compared to placebo [5] - When combined with semaglutide, the Activin E antibody enhanced total weight loss by an additional 9%, leading to an overall weight reduction of 34% and a 72% reduction in body fat [5]

Core Points - iBio, Inc. has received approval to transfer its common stock listing from NYSE American to the Nasdaq Capital Market, with trading expected to commence on March 4, 2025, under the symbol "IBIO" [1][2] - The CEO of iBio expressed optimism that the move to Nasdaq will enhance the visibility of the company's stock, improve trading liquidity, and provide greater exposure to institutional investors [2] Company Overview - iBio, Inc. is a biotech company focused on developing next-generation biopharmaceuticals for various diseases, including cardiometabolic diseases, obesity, and cancer, utilizing AI and advanced computational biology [2] - The company aims to transform drug discovery and accelerate development timelines through proprietary 3D modeling and innovative drug discovery platforms, creating a pipeline of breakthrough antibody treatments [2]

Company Overview - iBio, Inc. is a preclinical stage biotechnology company focused on developing precision antibodies using AI and machine learning technologies[243]. - The company has developed EngageTx™ technology for targeting bi-specific molecules, enhancing preclinical safety assessments[244]. - iBio's ShieldTx™ technology allows antibodies to remain inactive until they reach diseased tissue, potentially improving efficacy and safety[245]. - The proprietary StableHu technology has been shown to reduce lead optimization times by utilizing single-shot multi-dimensional optimization techniques[246]. Collaborations and Partnerships - iBio entered into an exclusive agreement with AstralBio for the development of IBIO-600, an antibody targeting myostatin, and initiated a bispecific antibody program for obesity and cardiometabolic disorders[251]. - The collaboration with AstralBio includes the option to license three additional obesity and cardiometabolic targets, enhancing the preclinical pipeline[269]. - The company aims to form strategic partnerships to streamline drug discovery processes and reduce costs for pharmaceutical and biotechnology companies[251]. - The company is exploring partnerships in diverse therapeutic areas, including CNS, immunology, and vaccines, to license its AI technology stack[251]. - The company has initiated collaborations to explore future opportunities using its AI Drug Discovery Platform[275]. Drug Development Programs - The company initiated a program to develop IBIO-600, a long-acting anti-myostatin antibody, with preliminary data from a preclinical study in obese mice showing dose-dependent prevention of lean mass loss when combined with a GLP-1 receptor agonist[279]. - The bispecific antibody program targeting myostatin/activin A is in late discovery, with early in vitro findings indicating stronger differentiation of progenitor cells into mature muscle cells compared to single-target antibodies[283]. - The company has advanced IBIO-101, a second-generation anti-CD25 mAb, to the IND-enabling phase, demonstrating a 43% reduction in tumor growth in preclinical studies compared to untreated animals[291][301]. - The lead TROP-2 x CD3 bispecific antibody showed a significant 36% reduction in tumor size within 14 days after a single dose in a humanized mouse model[295]. - The anti-CCR8 antibody demonstrated a 22% reduction in tumor size in preclinical studies for colon cancer, highlighting its potential as a targeted therapy[306]. - The company is leveraging its AI Drug Discovery Platform to identify new therapeutic candidates, including antibodies targeting Activin E for cardiometabolic disorders[285]. - The company is focusing on developing molecules for obesity treatment that can be used in combination with or as alternatives to incretin drugs, prioritizing targets with strong genetic validation[276]. Financial Performance - Revenue for the three months ended December 31, 2024, was $0.2 million, compared to no revenue for the same period in 2023[315]. - Research and Development (R&D) expenses for the three months ended December 31, 2024, were $1.9 million, an increase of approximately $0.4 million from $1.5 million in 2023[316]. - General and Administrative (G&A) expenses for the three months ended December 31, 2024, were approximately $2.7 million, a decrease of $0.3 million from $3.0 million in 2023[317]. - Total operating expenses for the three months ended December 31, 2024, were approximately $4.6 million, compared to approximately $4.5 million in the same period of fiscal year 2023[318]. - Net loss from continuing operations for the three months ended December 31, 2024, was ($4.4) million, or ($0.48) per share, compared to a net loss of approximately ($4.5) million, or ($2.42) per share, in 2023[320]. - For the six months ended December 31, 2024, net cash used in operating activities was approximately ($7.6) million, compared to ($10.0) million for the same period in 2023[327]. - The accumulated deficit as of December 31, 2024, was approximately ($322.2) million, an increase from approximately ($313.8) million as of December 31, 2023[330]. - The company plans to fund future operations through cash on hand, proceeds from commercialization, and potential asset sales or collaborations, but there is no assurance of success[333]. - The company recognized a loss from discontinued operations of approximately ($3.7) million for the three months ended December 31, 2023, primarily due to an impairment of fixed assets[319]. Market and Risk Factors - The company faces a highly competitive environment with rising interest rates and liquidity challenges, potentially requiring adjustments to cash flow projections and valuation assumptions[343]. - Critical accounting estimates remain consistent with the previous annual report, with ongoing evaluations that could lead to changes in consolidated financial statements[344]. - The company is not required to provide quantitative and qualitative disclosures about market risk as a smaller reporting company[345]. - No triggering events were identified in the first half of fiscal 2025, with ongoing monitoring of IP value as part of annual accounting policy[342].

Financial Results Announcement - iBio, Inc. announced its financial results for the quarter ended December 31, 2024, on February 10, 2025[5] - The press release detailing the financial results is attached as Exhibit 99.1[8] Company Information - The company is listed on the NYSE American under the trading symbol IBIO[3] - iBio, Inc. is not classified as an emerging growth company[4] Report Content - The report does not include specific financial metrics or performance indicators in the provided content[6]

Core Insights - iBio, Inc. reported financial results for the second quarter ended December 31, 2024, highlighting advancements in its preclinical pipeline and corporate governance [1][4]. Corporate Developments - The company strengthened its leadership with key Board appointments, emphasizing its commitment to innovation and execution in developing next-generation therapeutics [2]. - iBio made significant progress in its preclinical pipeline, including the in-licensing of IBIO-600, a novel Activin E antibody discovery, and the initiation of a bispecific antibody program targeting myostatin/activin A [2][5]. Financial Performance - Revenue for the quarter was reported at $0.2 million, attributed to services provided to a collaborative partner [5]. - Research and Development (R&D) and General & Administrative (G&A) expenses totaled approximately $4.6 million, reflecting a slight increase of about 3% compared to the same period in fiscal 2024 [5]. - The net loss from continuing operations for the quarter was approximately $4.4 million, or $0.48 per share, compared to a net loss of approximately $4.5 million, or $2.42 per share, in the same period of fiscal 2024 [5]. Cash Position - As of December 31, 2024, the company reported cash, cash equivalents, and restricted cash of approximately $7.2 million, which includes $0.2 million of restricted cash [5].

Company Overview - iBio Inc is a biotech company leveraging AI and advanced computational biology to develop next-generation biopharmaceuticals for cardiometabolic diseases, obesity, cancer, and other hard-to-treat diseases [1] - The company combines proprietary 3D modeling with innovative drug discovery platforms to create a pipeline of breakthrough antibody treatments [1] - iBio's mission is to transform drug discovery, accelerate development timelines, and unlock new possibilities in precision medicine [1] Recent Developments - iBio announced the closing of a private placement offering with members of its Board of Directors and Officers, totaling over $650,000 [3] - The investments from the Board of Directors underscore their confidence and support in iBio's strategy to advance as a clinical-stage biotech focused on developing therapeutics for cardiometabolic diseases, obesity, and other challenging diseases [4] Pipeline and Technology - iBio is building an innovative pipeline of therapeutics in cardiometabolic disease and obesity that aims to promote healthy weight loss [6] - The company's breakthrough antibody treatments are designed to reduce obesity while preserving muscle mass, promoting muscle growth, and preventing weight regain [6] - iBio's machine-learning-based drug discovery platform is driving the development of these candidates, which are being engineered for high developability and an extended half-life potentially enabling reduced dosing than current obesity therapeutics [6] Forward-Looking Statements - The press release contains forward-looking statements regarding iBio's innovative pipeline of therapeutics in cardiometabolic disease and obesity, including their potential to promote healthy weight loss and address significant unmet medical needs [5] - These statements are based on current estimates and assumptions and are subject to various risks and uncertainties [5]

Core Insights - iBio, Inc. has successfully closed a private placement offering totaling over $650,000 with its Board of Directors and Officers, indicating strong internal support for the company's strategic direction [1][2] Company Overview - iBio is an AI-driven biotech company focused on developing precision antibody immunotherapies for cardiometabolic diseases, obesity, cancer, and other challenging diseases [4] - The company utilizes advanced computational biology and proprietary 3D modeling to create a pipeline of innovative therapeutics aimed at addressing significant unmet medical needs [4] Product Pipeline - iBio is developing a pipeline of therapeutics specifically targeting cardiometabolic diseases and obesity, with a focus on promoting healthy weight loss [3] - The antibody treatments are designed to reduce obesity while preserving muscle mass, promoting muscle growth, and preventing weight regain [3] - The company's machine-learning-based drug discovery platform is aimed at creating candidates with high developability and an extended half-life, potentially allowing for reduced dosing compared to current obesity therapeutics [3]