Core Insights - Iovance Biotherapeutics announced five-year results from the Phase 2 C-144-01 clinical trial for Amtagvi, demonstrating a five-year overall survival rate of 20% in patients with advanced melanoma previously treated with immune checkpoint inhibitors [1][2][3] Clinical Trial Results - The C-144-01 trial involved 153 patients with advanced melanoma, showing a median overall survival (OS) of 13.9 months and an objective response rate of 31.4%, with complete responses in 5.9% and partial responses in 25.5% of patients [3][7] - Among responders, the median duration of response was 36.5 months, with 31.3% of responders maintaining ongoing responses at the five-year assessment [3][5] Safety Profile - Adverse events were consistent with known safety profiles of nonmyeloablative lymphodepletion and interleukin-2 administration, with a rapid decrease in incidence within the first two weeks post-infusion and no new or late-onset treatment-related adverse events reported [4][5] Regulatory Approval - The U.S. FDA granted accelerated approval to Amtagvi in February 2024 for adult patients with unresectable or metastatic melanoma previously treated with a PD-1 blocking antibody, marking it as the first one-time T cell therapy for solid tumors [7][11] Future Developments - Iovance is conducting the TILVANCE-301 Phase 3 trial to confirm the clinical benefit of Amtagvi in frontline advanced melanoma [7][10]

Core Viewpoint - Iovance Biotherapeutics, Inc. is facing a securities class action lawsuit for allegedly misleading investors about its growth potential and ability to meet demand for its cancer treatments [1][2]. Group 1: Lawsuit Details - The lawsuit, Farberov v. Iovance Biotherapeutics, Inc., claims that the company made overwhelmingly positive statements while concealing material adverse facts regarding its operational readiness [2][5]. - The class period for the lawsuit is from May 9, 2024, to May 8, 2025, with a lead plaintiff deadline set for July 14, 2025 [2]. Group 2: Stock Performance - On May 9, 2025, Iovance's stock price dropped approximately 44.8%, falling from $3.17 to $1.75, following the announcement of disappointing financial results and a downward revision of revenue guidance [3]. Group 3: Financial Performance - In its July 2024 announcement, Iovance attributed the lower revenue guidance to a month-long reduction in manufacturing capacity due to maintenance, lower-than-expected sales of Proleukin, and a variable pace in the treatment of patients with newer therapies [4]. Group 4: Investor Claims - Investors argue that the disclosures revealed previously concealed issues that negatively impacted the company's growth prospects, contradicting earlier positive statements about its operational readiness [5].

NEW YORK, May 22, 2025 (GLOBE NEWSWIRE) -- Levi & Korsinsky, LLP notifies investors in Iovance Biotherapeutics, Inc. ("Iovance" or the "Company") (NASDAQ: IOVA) of a class action securities lawsuit. CLASS DEFINITION: The lawsuit seeks to recover losses on behalf of Iovance investors who were adversely affected by alleged securities fraud between May 9, 2024 and May 8, 2025. Follow the link below to get more information and be contacted by a member of our team: https://zlk.com/pslra-1/iovance-biotherapeutics ...

NEW YORK, May 22, 2025 /PRNewswire/ -- The Gross Law Firm issues the following notice to shareholders of Iovance Biotherapeutics, Inc. (NASDAQ: IOVA).Shareholders who purchased shares of IOVA during the class period listed are encouraged to contact the firm regarding possible lead plaintiff appointment. Appointment as lead plaintiff is not required to partake in any recovery.CONTACT US HERE:https://securitiesclasslaw.com/securities/iovance-biotherapeutics-inc-loss-submission-form/?id=149542&from=4CLASS PERI ...

NEW ORLEANS, May 21, 2025 (GLOBE NEWSWIRE) -- ClaimsFiler, a FREE shareholder information service, reminds investors that they have until July 15, 2025 to file lead plaintiff applications in a securities class action lawsuit against Iovance Biotherapeutics, Inc. (“Iovance” or the “Company”) (NasdaqGM: IOVA), if they purchased the Company’s securities between May 9, 2024 and May 8, 2025, inclusive (the “Class Period”). This action is pending in the United States District Court for the Northern District of Ca ...

Core Viewpoint - The Gross Law Firm has issued a notice to shareholders of Iovance Biotherapeutics, Inc. regarding a class action lawsuit due to misleading statements about the company's growth potential and subsequent stock price decline [1][3]. Summary by Relevant Sections Class Period and Allegations - The class period for the lawsuit is from August 8, 2024, to May 8, 2025 [3]. - Allegations include that Iovance provided overly positive statements while concealing material adverse facts about its ability to generate demand for its treatments [3]. - The company announced reduced revenue guidance for fiscal year 2024 due to maintenance issues, lower-than-expected Proleukin sales, and a variable pace of treatment initiation [3]. Stock Price Impact - Following the announcement of reduced guidance, Iovance's stock price fell from $3.17 per share on May 8, 2025, to $1.75 per share on May 9, 2025, representing a decline of approximately 44.795% in one day [3]. Next Steps for Shareholders - Shareholders are encouraged to register for the class action by July 14, 2025, to potentially become lead plaintiffs [4]. - Registered shareholders will receive updates through a portfolio monitoring software [4]. Law Firm's Commitment - The Gross Law Firm aims to protect investors' rights and seeks recovery for losses incurred due to misleading statements that inflated stock prices [5].

NEW YORK, May 21, 2025 (GLOBE NEWSWIRE) -- WHY: Rosen Law Firm, a global investor rights law firm, announces the filing of a class action lawsuit on behalf of purchasers of securities of Iovance Biotherapeutics, Inc. (NASDAQ: IOVA) between May 9, 2024 and May 8, 2025, both dates inclusive (the “Class Period”). A class action lawsuit has already been filed. If you wish to serve as lead plaintiff, you must move the Court no later than July 14, 2025. SO WHAT: If you purchased Iovance securities during the Cla ...

NEW YORK, May 21, 2025 (GLOBE NEWSWIRE) -- Scott+Scott Attorneys at Law LLP (“Scott+Scott”), an international shareholder and consumer rights litigation firm, alerts investors that a securities class action lawsuit has been filed in the United States District Court for the Northern District of California against Iovance Biotherapeutics, Inc. (“Iovance” or the “Company”) (NASDAQ: IOVA), and certain of its former and current officers and/or directors (collectively, “Defendants”). The Class Action asserts clai ...

Core Viewpoint - Iovance Biotherapeutics, Inc. is facing a securities class action lawsuit for allegedly misleading investors about its growth potential and ability to meet market demand for its cancer treatments [1][2]. Company Overview - Iovance Biotherapeutics is a biotechnology firm that specializes in cancer treatments [1]. - The lawsuit claims that the company and its executives made overly positive statements while concealing material adverse facts about its operational readiness [2][5]. Legal Proceedings - The class action lawsuit is titled Farberov v. Iovance Biotherapeutics, Inc., et al., and covers the period from May 9, 2024, to May 8, 2025 [1][2]. - The lead plaintiff deadline for the lawsuit is set for July 14, 2025 [2]. Financial Impact - On May 9, 2025, Iovance's stock price dropped approximately 44.8%, from $3.17 to $1.75, following the announcement of disappointing financial results and a downward revision of revenue guidance [3]. - The company attributed its lower revenue guidance to a significant reduction in manufacturing capacity and lower-than-expected sales of its existing therapy, Proleukin [4]. Allegations of Misleading Information - The lawsuit argues that the disclosures made by Iovance revealed previously concealed issues that negatively impacted the company's growth prospects [5]. - Investors contend that earlier positive statements misrepresented Iovance's operational readiness and commercialization efforts [5].

NEW YORK, May 21, 2025 (GLOBE NEWSWIRE) -- Leading securities law firm Bleichmar Fonti & Auld LLP announces that a lawsuit has been filed against Iovance Biotherapeutics, Inc. (NASDAQ: IOVA) and certain of the Company’s senior executives for potential violations of the federal securities laws. If you invested in Iovance you are encouraged to obtain additional information by visiting https://www.bfalaw.com/cases-investigations/iovance-biotherapeutics-inc-class-action-lawsuit. Investors have until July 14, 20 ...